Thrombocytosis in gynecologic malignancies.

abstract：:Glioblastoma multiforme (GBM), a grade IV glioma, appears to harbor therapy-resistant cancer stem cells (CSCs) that are the major cause of recurrence. All-trans retinoic acid (ATRA), a derivative of retinoid, is capable of differentiating a variety of stem cells, as well as normal neural progenitor cells, and down-reg...

journal_title：Anticancer research

authors： Karsy M,Albert L,Tobias ME,Murali R,Jhanwar-Uniyal M

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the metallothionein (MT), maintenance protein 2 (Mcm-2) and Ki-67 expressions in adrenocortical adenomas and carcinomas in comparison to normal tissue and evaluate the correlations between these markers of proliferation and between these markers and tumor diameter. MATERI...

journal_title：Anticancer research

authors： Szajerka A,Dziegiel P,Szajerka T,Zabel M,Winowski J,Grzebieniak Z

更新日期：2008-09-01 00:00:00

abstract：AIM:We examined whether the perioperative systemic inflammation score (SIS), which describes systemic inflammation and/or malnutrition, affected the tumor recurrence and survival in advanced gastric cancer patients. PATIENTS AND METHODS:The study retrospectively analyzed 160 patients with stage II/III gastric cancer w...

journal_title：Anticancer research

authors： Hara K,Aoyama T,Yamada T,Nakazono M,Nagasawa S,Shimoda Y,Kumazu Y,Numata M,Hayashi T,Tamagawa H,Shiozawa M,Morinaga S,Yukawa N,Rino Y,Masuda M,Ogata T,Oshima T

更新日期：2020-03-01 00:00:00

abstract：:Measurement of CA125 is well established in the diagnosis and follow-up of ovarian cancer. CA125 determination is usually performed with the monoclonal antibodies OC125 and M11. For the IMMULITE OM-MA chemoluminsence assay (DPC Biermann, Bad Nauheim, Germany) the monoclonal antibody OV185 is used. We analysed CA125 se...

journal_title：Anticancer research

authors： Gebauer G,Rieger M,Jäger W,Lang N

更新日期：1999-07-01 00:00:00

abstract：:Major drawbacks to present-day cancer chemotherapy are its intrinsic lack of selectivity for tumour cells, resulting in severe damage to normal rapidly dividing cells, and the widespread emergence of drug resistance. Here experimental evidence is presented demonstrating that PB-100, a beta-carboline alkaloid, selectiv...

journal_title：Anticancer research

authors： Beljanski M,Crochet S,Beljanski MS

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:The aim of the study was to document the delay in diagnosis of Hodgkin's disease (HD) and clarify the impact on clinical stage and survival in our region. MATERIAL AND METHODS:A retrospective study of the records of 50 patients treated for primary HD in northern-Norway in the time period 1985 - 1993 was per...

journal_title：Anticancer research

authors： Norum J

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND/AIM:Inflammation is a key process in gastric carcinogenesis. Cytokines are mediators of inflammation and are involved in metastasis and tumorigenicity. We previously assessed the role of cytokine gene polymorphisms in gastric cancer risk in Chile. In the present study, we aimed to analyze whether these polym...

journal_title：Anticancer research

authors： Gonzalez-Hormazabal P,Romero S,Musleh M,Bustamante M,Stambuk J,Pisano R,Lanzarini E,Chiong H,Rojas J,Castro VG,Jara L,Berger Z

更新日期：2018-10-01 00:00:00

abstract：:The widespread use of endoscopy and imaging in combination with the continuous update of the staging systems for neuroendocrine tumors has led to an increase in the incidence of small intestinal neuroendocrine tumors (si-NENs) globally. Despite high survival rates, severe complications may occur even in early stages d...

journal_title：Anticancer research

authors： Moris D,Ntanasis-Stathopoulos I,Tsilimigras DI,Vagios S,Karamitros A,Karaolanis G,Griniatsos J,Papalampros A,Papaconstantinou I,Glantzounis GK,Spartalis E,Blazer DG 3rd,Felekouras E

更新日期：2018-03-01 00:00:00

abstract：:Interferon-alpha (IFN-alpha) has been found to exert multiple enhancing effects in the immune response in vitro, IFN-alpha has been also used in clinical trials with variable response rates. The aim of the present study was to assess the effectiveness of IFN-alpha in the treatment of 25 patients with malignant pleural...

journal_title：Anticancer research

authors： Stathopoulos GP,Baxevanis CN,Papadopoulos NG,Zarkadis IK,Papacostas P,Michailakis E,Tsiatas ML,Papamichail M

更新日期：1996-11-01 00:00:00

abstract：:Pseudomyxoma peritonei (PMP) is a clinical condition characterized by diffuse intraabdominal spread of mucinous tumor implants that form on peritoneal surfaces. To complement the efficacy of cytoreductive surgery, an effective cytotoxic drug is required as an intraperitoneal agent for microscopic cytoreduction locoreg...

journal_title：Anticancer research

authors： Chua TC,Akther J,Yao P,Morris DL

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Despite many years of clinical research and development, nausea and vomiting remain challenging toxicities related to chemotherapy. The aim of our study was to clarify the significance of non-pharmacological, patient-related risk factors for chemotherapy-induced nausea and vomiting. Furthermore, we aimed to ...

journal_title：Anticancer research

authors： Rittmeister H,Oskay-Özcelik G,Richter R,Sehouli J,Grabowski JP

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND/AIM:Long interspersed nuclear element-1 (LINE-1) methylation status is a marker for global DNA methylation. However, the relationship between LINE-1 methylation and the biology of lung adenocarcinoma remains unclear. Here, we aimed to examine the role of LINE-1 in lung cancer. MATERIALS AND METHODS:LINE-1 m...

journal_title：Anticancer research

authors： Kitahara H,Okamoto T,Shimamatsu S,Kohno M,Morodomi Y,Tagawa T,Kitao H,Okano S,Oda Y,Maehara Y,Mori M

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND/AIM:Lung cancer is the first cause of cancer related deaths in both males and females. Epithelial-mesenchymal transition (EMT) is a reversible process by which epithelial cells transform to mesenchymal stem cells by losing their cell polarity and cell-to-cell adhesion, gaining migratory and invasive properti...

journal_title：Anticancer research

authors： Tsoukalas N,Aravantinou-Fatorou E,Tolia M,Giaginis C,Galanopoulos M,Kiakou M,Kostakis ID,Dana E,Vamvakaris I,Korogiannos A,Tsiambas E,Salemis N,Kyrgias G,Karameris A,Theocharis S

更新日期：2017-04-01 00:00:00

abstract：:Tricot et al have reported that the nucleoside analog tiazofurin can induce hematologic remissions in patients with chronic myelogenous leukemia in blast crisis (CML-BC). These reports prompted us to begin a derivative, phase II trial of tiazofurin in CML-BC to determine if the promising findings reported by these inv...

journal_title：Anticancer research

authors： Wright DG,Boosalis MS,Waraska K,Oshry LJ,Weintraub LR,Vosburgh E

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:A recent study suggested that the p53Arg (at residue 72) homozygous genotype could be a potential genetic risk factor for cervical cancer among white women. To confirm this result we examined the proportion of p53 genotypes in a larger number of patients with cervical cancer and in patients with squamous int...

journal_title：Anticancer research

authors： Szarka K,Veress G,Kónya J,Gergely L

更新日期：1999-05-01 00:00:00

abstract：:A report that effects of butyrate on some cells may be mediated by activation of AMP-activated protein kinase (AMPK) prompted this study which examines if other AMPK activators can induce differentiation and inhibit proliferation of colon cancer cells in a manner similar to butyrate. Using induction of alkaline phosph...

journal_title：Anticancer research

authors： Lea MA,Chacko J,Bolikal S,Hong JY,Chung R,Ortega A,desbordes C

更新日期：2011-02-01 00:00:00

abstract：:The adenomatous polyposis coli (APC) gene was investigated in Swedish patients with familial adenomatous polyposis (FAP). A combination of analyses including single stranded conformation polymorphism (SSCP), heteroduplex (HD), protein truncation test (PTT) and direct sequencing was used to enable optimal mutation dete...

journal_title：Anticancer research

authors： Nordling M,Engwall Y,Wahlström J,Wiklund L,Eriksson MA,Gustavsson B,Fasth S,Larsson PA,Martinsson T

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND/AIM:In addition to its cytocidal effects as a microtubule dynamics inhibitor, eribulin mesylate (eribulin) regulates the tumour microenvironment. We examined the clinical significance of tumour infiltrating lymphocytes (TILs) and transforming growth factor-β (TGF-β), which are local markers of host immunity,...

journal_title：Anticancer research

authors： Kashiwagi S,Asano Y,Goto W,Takada K,Morisaki T,Kouhashi R,Yabumoto A,Tanaka S,Takashima T,Ohsawa M,Hirakawa K,Ohira M

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Basic conventional prognostic factors for breast cancer include the age of the patient, tumor grade, regional lymph nodes status, and estrogen (ER) and progesterone (PR) receptor status. Positivity of the HER2 receptor (c-erbB-2) seems to be a new prognostic and predictive factor. Prognostic factors seem to ...

journal_title：Anticancer research

authors： Finek J,Holubec L Jr,Topolcan O,Elgrova L,Skalova A,Pecen L

更新日期：2007-07-01 00:00:00

abstract：:The effects induced by a low dose cyclophosphamide treatment (CPA) along with an attempt of estradiol-17-beta (E2) cell recruitment, on the bioenergetics and the phosphomonoesters/phosphodiesters (PME/PDE) ratio in the transplantable MXT mouse mammary tumor have been studied by 31P-NMR spectroscopy in vivo. Our result...

journal_title：Anticancer research

authors： Scheiber C,Kiss R,De Launoit Y,Frühling J

更新日期：1988-05-01 00:00:00

abstract：:The effect of PSK, a protein-bound polysaccharide and an immunomodulator, on lymphocytes was examined in vitro for 36 patients with gastric cancer and 26 with colorectal cancer. Cultured lymphocytes with PSK at 100 micrograms/ml increased the level of DNA synthesis, as determined by the 3H-thymidine uptake, from 0.9 t...

journal_title：Anticancer research

authors： Sugimachi K,Maehara Y,Kusumoto T,Okamura T,Korenaga D,Kohnoe S,Baba H,Anai H

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND/AIM:The identification of a series of oxadiazole-based compounds, as promising antiproliferative agents, has been previously reported. The aim of this study was to explore the SAR of newly-synthesized oxadiazole derivatives and identify their molecular targets. MATERIALS AND METHODS:A small library of 1,2,5...

journal_title：Anticancer research

authors： Gelain A,Mori M,Meneghetti F,Porta F,Basile L,Marverti G,Asai A,Hyeraci M,García-Argáez AN,Via LD,Guccione S,Villa S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIM:Long-term results of a study investigating potential prognostic factors for treatment outcomes in patients with stage III esophageal cancer are presented. PATIENTS AND METHODS:In 64 patients, the impact of tumor cell expression of erythropoietin (EPO) and erythropoietin-receptor (EPO-R) and ten addition...

journal_title：Anticancer research

authors： Rades D,Bajrovic A,Schild SE,Thorns C,Kilic E

更新日期：2014-08-01 00:00:00

abstract：:This report describes a precise molecular analysis of a rare case of Philadelphia chromosome (Ph) positive acute myeloid leukemia (AML) (FAB classification M2). Phenotypic markers were positive for cells of the myeloid lineage, but negative for B cell and T cell lineage. The leukemic cells carried a Philadelphia chrom...

journal_title：Anticancer research

authors： Yoshida A,Kishi S,Kita K,Kamada N,Nakamura T,Ueda T

更新日期：1997-01-01 00:00:00

abstract：AIM:Adjuvant treatment is still controversially discussed for elderly colon cancer (CC) patients. Our aim was to investigate the benefit of adjuvant treatment for younger (<70 years) and elderly (≥70 years) patients. PATIENTS AND METHODS:The long-term outcome of patients (n=855) enrolled in a randomized controlled tri...

journal_title：Anticancer research

authors： Mayer B,Sander S,Paschke S,Henne-Bruns D,Link KH,Kornmann M,Study Group Oncology of Gastrointestinal Tumors (FOGT).

更新日期：2015-10-01 00:00:00

abstract：:Details of 197 colorectal carcinomas from 180 patients were retrieved from our files, with the aim of analyzing the clinical histories and pathological parameters of all patients up to 40 years, and to support these data with the results of the DNA content analysis of tumoral cells by static cytometry. The incidence o...

journal_title：Anticancer research

authors： Caruso ML,Rizzi E

更新日期：1998-05-01 00:00:00

abstract：:The influence of bovine serum albumin on estradiol-17 beta growth and responsiveness of human mammary cancer MCF-7 cells was studied and compared to that of dextran-coated charcoal-treated fetal calf serum and other bovine serum proteins. To reveal the protein factor role, a culture defined medium was used. It was com...

journal_title：Anticancer research

authors： Germain P,Harbrioux G

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND/AIM:Cold atmospheric plasma (CAP) attenuates tumor cell proliferation and induces apoptosis in various cell lines. While exerting marginal effects on non-neoplastic cells this unfolds promising applications in cancer therapy. The aim of the study was to analyse the effects of different CAP sources and applic...

journal_title：Anticancer research

authors： Gümbel D,Suchy B,Wien L,Gelbrich N,Napp M,Kramer A,Ekkernkamp A,Daeschlein G,Stope MB

更新日期：2017-10-01 00:00:00

abstract：:The human MAGE gene products are recognized by major histocompatibility complex-restricted cytotoxic T lymphocytes. We analyzed by RT-PCR the expression of MAGE-1, MAGE-2, MAGE-3 and HLA-A2 genes in 10 human gastric cancer cell lines and 46 human stomachs removed due to advanced gastric carcinomas. All the cell lines ...

journal_title：Anticancer research

authors： Ofuji S,Ikeda M,Tsujitani S,Ikeguchi M,Kaibara N,Yuasa I,Mitsuya K,Katoh M,Ito H

更新日期：1998-09-01 00:00:00

abstract：:A number of human tumor cell lines originating in tissues which normally express high levels of P-glycoprotein were examined for the expression of mdr-1 RNA and P-glycoprotein and their sensitivity to doxorubicin and vincristine. There was a wide variation in expression levels and in drug sensitivity among the cell li...

journal_title：Anticancer research

authors： Duensing TD,Slate DL

更新日期：1994-01-01 00:00:00