Abstract：
AIM:We examined whether the perioperative systemic inflammation score (SIS), which describes systemic inflammation and/or malnutrition, affected the tumor recurrence and survival in advanced gastric cancer patients. PATIENTS AND METHODS:The study retrospectively analyzed 160 patients with stage II/III gastric cancer who underwent curative resection at the Kanagawa Cancer Center. The SIS was evaluated before surgery, one week after surgery and one month after surgery, as determined by the serum albumin level (cut-off value=4.0 g/dl) and lymphocyte-to-monocyte ratio (cut-off value=4.44). RESULTS:A high SIS at one month after surgery was identified as an independent predictor for overall survival [hazard ratio (HR)=2.143, p=0.020] and showed a marginal significance for the relapse-free survival (HR=1.814, p=0.053) in multivariate analyses. CONCLUSION:The SIS at one month after surgery is a useful biomarker for predicting the long-term outcome in patients with advanced gastric cancer.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Hara K,Aoyama T,Yamada T,Nakazono M,Nagasawa S,Shimoda Y,Kumazu Y,Numata M,Hayashi T,Tamagawa H,Shiozawa M,Morinaga S,Yukawa N,Rino Y,Masuda M,Ogata T,Oshima Tdoi
10.21873/anticanres.14095subject
Has Abstractpub_date
2020-03-01 00:00:00pages
1503-1512issue
3eissn
0250-7005issn
1791-7530pii
40/3/1503journal_volume
40pub_type
杂志文章abstract：:Chk1 (checkpoint kinase 1) is a serine-threonine kinase that is critical for G2/M arrest in response to DNA damage. Chk1 phosphorylates Cdc25C at serine-216, a major regulatory site, in response to DNA damage. Furthermore, Chk1 also phosphorylates Cdc25A on serine 123 which accelerates its degradation through the ubiq...
journal_title：Anticancer research
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更新日期：2004-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.11769
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:The benefit of tissue microarray (TMA) is its capability to analyse large numbers of tissue samples in a uniform fashion. This study was designed to evaluate the capability of TMA for analyzing the status of death-associated protein kinase 1 (DAPK1) in breast cancer patient and to explore its potential in th...
journal_title：Anticancer research
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更新日期：2011-10-01 00:00:00
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journal_title：Anticancer research
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journal_title：Anticancer research
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更新日期：2015-06-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2001-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2011-02-01 00:00:00
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journal_title：Anticancer research
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更新日期：2001-03-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：1996-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13850
更新日期：2019-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1987-05-01 00:00:00
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doi：
更新日期：2005-09-01 00:00:00
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doi：
更新日期：1993-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2006-09-01 00:00:00
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journal_title：Anticancer research
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更新日期：2003-03-01 00:00:00
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更新日期：2004-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,评审
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doi：
更新日期：2016-06-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：1994-05-01 00:00:00
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更新日期：2012-01-01 00:00:00
