Abstract：
BACKGROUND/AIM:Our original hypothesis was that the rectus sheath block (RSB) analgesia could enhance patient satisfaction and decrease pain following midline laparotomy. PATIENTS AND METHODS:Initially, 56 patients were randomized into four groups; control group (n=12), single-dose (n=16), repeated-dose (n=12) and continuous infusion (n=16) RSB analgesia groups. The BPI (Brief Pain Inventory) survey was conducted preoperatively and at one and four weeks and 12 months postoperatively. The patients pain 24 h postoperatively and satisfaction 48 h postoperatively was filled on an 11-point numeric rating scale (NRS). RESULTS:The repeated-dose group had lower BPI severity score (p=0.045) and BPI interference score (p=0.043) mean values postoperatively compared to the three other groups separately. Also, the time effect on the linear mixed model in BPI interference score mean values was statistically significant (p=0.008), which means that in the repeated dose group preoperative BPI severity score [2.7 (3.9)] and interference score [4.3 (4.2)] mean (SD) values were significantly higher than the BPI severity score [1.3 (0.8)] and interference score [1.5 (1.8)] mean (SD) values following surgery. CONCLUSION:The higher elevation in BPI severity score and decrease in interference score values in the repeated dose group and also the time effect in a linear mixed model in BPI interference score were statistically significant.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Kuosmanen V,Ruottinen M,Rahkola D,Saimanen I,Kaaronen V,Selander T,Purdy M,Kokki H,Kokki M,Eskelinen Mdoi
10.21873/anticanres.13890subject
Has Abstractpub_date
2019-12-01 00:00:00pages
6751-6757issue
12eissn
0250-7005issn
1791-7530pii
39/12/6751journal_volume
39pub_type
杂志文章,随机对照试验abstract：:P-glycoprotein (P-gp) actively pumps out a number of anticancer drugs, such as epirubicin, from tumor cells. P-gp is also expressed in the small intestine under normal physiological conditions. Inhibition of intestinal P-gp function using MDR reversing agents may enhance the oral bioavailability of some chemotherapeut...
journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:Activating Gs a mutations have been identified in most instances of fibrous dysplasia (FD). This mutation leads to consistently elevated intracellular cyclic adenosine monophosphate (cAMP) levels, with various biological consequences. The development of secondary sarcoma in FD is a rare but well-established ...
journal_title：Anticancer research
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更新日期：2006-03-01 00:00:00
abstract：:The effects of the 18 carbon chain length series of fatty acids on the viability of a 3T6 derived mouse fibroblast cell line were tested. An overall concentration dependent cytotoxic effect was demonstrated with the saturated fatty acid, and cis- and trans- mono- and dienoic fatty acids; however, within a narrow range...
journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：1987-01-01 00:00:00
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更新日期：2012-05-01 00:00:00
abstract：:The quest for immunotherapies against cancer has been ongoing for many years, and a greater understanding of the normal mechanisms involved in developing immune responses has now led to clinically effective therapies. With the licensing of Ipilimumab and Sipuleucel-T, immunotherapeutic strategies are taking their plac...
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更新日期：2001-07-01 00:00:00
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pub_type： 杂志文章,多中心研究
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2000-03-01 00:00:00
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