Correlation Between Expression of Twist and Podoplanin in Ductal Breast Carcinoma.

abstract：BACKGROUND/AIM:Autophagy can be either tumor promotive or suppressive. We previously identified an autophagy-inducing activity in the 30-100 kDa fraction of areca-nut-extract (ANE 30-100K) and showed that several tumor cells subjected to chronic ANE 30-100K stimulation (CAS) exhibited higher resistance against stressed...

journal_title：Anticancer research

authors： Chiu CT,Liu SY,Yen CY,Liu BY,Sun ZY,Wu CY,Deng JL,Liu YC,Lin MH

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIM:Roles for mutant (mt) KRAS in the innate immune microenvironment in colorectal cancer (CRC) were explored. MATERIALS AND METHODS:Human CRC HCT116-derived, mtKRAS-disrupted (HKe3) cells that express exogenous mtKRAS and allogenic cytokine-activated killer (CAK) cells were co-cultured in 3D floating (3DF)...

journal_title：Anticancer research

authors： Nishi K,Ishikura S,Umebayashi M,Morisaki T,Inozume T,Kinugasa T,Aoki M,Nimura S,Swain A,Yoshida Y,Hasegawa S,Nabeshima K,Sakata T,Shirasawa S,Tsunoda T

更新日期：2020-08-01 00:00:00

abstract：:Alteration of T-cell-associated signal transduction molecules has recently been implicated in immune suppression in tumour-bearing hosts. Here we report the immunoregulatory effects of human lactoferrin (LF) on zeta-chain expression in peripheral blood T lymphocytes from cervical cancer patients and healthy donors. By...

journal_title：Anticancer research

authors： Frydecka I,Zimecki M,Bocko D,Kosmaczewska A,Teodorowska R,Ciszak L,Kruzel M,Wlodarska-Polinsk J,Kuliczkowski K,Kornafel J

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:The aim of this work was to study the constituents and cytotoxicity of the essential oils from the fruits of Angelica archangelica growing in Iceland. MATERIALS AND METHODS:Three samples of essential oils were prepared by steam distillation. Their composition was established with GC/MS. The effects of the o...

journal_title：Anticancer research

authors： Sigurdsson S,Ogmundsdottir HM,Gudbjarnason S

更新日期：2005-05-01 00:00:00

abstract：METHODS:Induction chemotherapy, consisting of 3 courses of cisplatin (30 mg/m2/i.v. 1st and 2nd day), epirubicin (30 mg/m2/i.v. 1st and 2nd day), etoposide (75 mg/m2/i.v. 1st and 2nd day) and bleomycin (15 mg/i.v. 1st and 2nd day), prior to radical hysterectomy and lymph nodes resection, was used in the primary treatme...

journal_title：Anticancer research

authors： Panetta A,Angelelli B,Martoni A

更新日期：1999-01-01 00:00:00

abstract：AIM:We examined whether the perioperative systemic inflammation score (SIS), which describes systemic inflammation and/or malnutrition, affected the tumor recurrence and survival in advanced gastric cancer patients. PATIENTS AND METHODS:The study retrospectively analyzed 160 patients with stage II/III gastric cancer w...

journal_title：Anticancer research

authors： Hara K,Aoyama T,Yamada T,Nakazono M,Nagasawa S,Shimoda Y,Kumazu Y,Numata M,Hayashi T,Tamagawa H,Shiozawa M,Morinaga S,Yukawa N,Rino Y,Masuda M,Ogata T,Oshima T

更新日期：2020-03-01 00:00:00

abstract：:The cytosol hormone receptors were extracted from rabbit uteri and human tumors with tris buffer systems for three consecutive homogenization and centrifugation processes to obtain three cytosols C-1, C-2, and C-3. The assay results evaluated revealed that minimal to tremendous amounts of receptor activities were pres...

journal_title：Anticancer research

authors： Chen YM,Rice RG,Vaughn CB

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND/AIM:Vimentin3 (Vim3) was recently described as a tumour marker for the direct discrimination between benign and malignant kidney tumours. Here, we examined its expression in prostate cancer (PCa) cell lines and the regulation of its expression by endothelin receptors. MATERIALS AND METHODS:Prostate cancer c...

journal_title：Anticancer research

authors： KÖditz B,Stog A,GÖbel H,Heidegger I,Fries J,Heidenreich A,VON Brandenstein M

更新日期：2021-01-01 00:00:00

abstract：:In a previous study we demonstrated spontaneous fragility and hypersensitivity to fragile site induction by aphidicolin in lymphocytes from some neuroblastoma patients and their parents. Here we report data based on a total of 40 patients and 37 families. Possible correlations between higher sensitivity to aphidicolin...

journal_title：Anticancer research

authors： Vernole P,Tedeschi B,Melino G,Pianca C,Nicoletti B

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Bone lesions in multiple myeloma (MM) are screened with radiological skeletal survey (RSS) due to its widespread availability. Although bone lesions can be missed by RSS, more sensitive radiological surveys are not as yet recommended for routine use due to the low availability of the methodology and economic...

journal_title：Anticancer research

authors： Engelhardt M,Kleber M,Frydrychowicz A,Pache G,Schmitt-Gräff A,Wäsch R,Durie BG

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:The rat model of breast cancer induced by the administration of N-methyl-nitrosourea (NMU) constitutes a useful tool for dissecting the initiation, promotion and progression process of carcinogenesis. Angiogenesis, the recruitment of new blood vessels, is an essential component of the metastatic pathway. Tum...

journal_title：Anticancer research

authors： Carrera MP,Ramírez-Expósito MJ,Valenzuela MT,García MJ,Mayas MD,Martínez-Martos JM

更新日期：2004-03-01 00:00:00

abstract：:The local growth and metastatic potential of colorectal cancer is the outcome of a dynamic balance between cancer cells and the immune system, at both a local and systemic level, summarized as the "seed and soil" hypothesis. Until recently, the staging and treatment approaches for colorectal cancer appeared to be orie...

journal_title：Anticancer research

authors： Seretis F,Seretis C,Youssef H,Chapman M

更新日期：2014-05-01 00:00:00

abstract：:Amitriptyline, a tricyclic antidepressant, was able to reverse the multidrug resistance efflux pump of human colon cancer subline SW 620 and multidrug resistant (mdr) mouse lymphoma cells by decreasing rhodamine 123 efflux. The inhibitory effect of amitriptyline on the efflux pump was dose dependent. An investigation ...

journal_title：Anticancer research

authors： Varga A,Nugel H,Baehr R,Marx U,Hevér A,Nacsa J,Ocsovszky I,Molnar J

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Green tea polyphenols (GTPs) have been proposed as promising candidates for chemoprevention. However, GTPs levels are maintained relatively low in the blood and are chemically-unstable. Lipid-soluble tea polyphenols (LTPs) are products of modified GTPs with ester linkage with fatty acids. LTPs are lipophilic...

journal_title：Anticancer research

authors： Shen T,Khor SC,Zhou F,Duan T,Xu YY,Zheng YF,Hsu S,DE Stefano J,Yang J,Xu LH,Zhu XQ

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The chronomodulated infusion of 5-FU, FA and oxaliplatin allows a significant increase in dose intensity and antitumor efficacy in patients with metastatic colorectal cancer. Here we investigated if substitution of oxaliplatin with cisplatin produced a similar antitumor activity in previously untreated patie...

journal_title：Anticancer research

authors： Natoli C,Scognamiglio MT,Martino MT,Irtelli L,De Tursi M,Cianchetti E,Mascitelli E,Tinari N,Iacobelli S

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:The rearrangement of actin cytoskeleton is being increasingly considered a marker of cancer cell activity, but the fine structure and remodeling of microfilaments within tumor tissue still remains unclear. MATERIALS AND METHODS:We used the recently introduced silicon-rhodamine (SiR)-actin dye to visualize e...

journal_title：Anticancer research

authors： Klementieva NV,Snopova LB,Prodanets NN,Furman OE,Dudenkova VV,Zagaynova EV,Lukyanov KA,Mishin AS

更新日期：2016-10-01 00:00:00

abstract：:Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a major endogenous regulator of matrix metalloproteinases. This study examined the relation between TIMP-1 gene expression and postoperative mortality in patients with colorectal cancer (CRC). Specimens of CRC were obtained from 202 patients. The relative expression ...

journal_title：Anticancer research

authors： Inagaki D,Oshima T,Yoshihara K,Tamura S,Kanazawa A,Yamada T,Yamamoto N,Sato T,Shiozawa M,Morinaga S,Akaike M,Fujii S,Numata K,Kunisaki C,Rino Y,Tanaka K,Masuda M,Imada T

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Antibodies against human epidermal growth factor receptor 2 (HER2) affect metastatic breast cancer cells and cardiac myocytes. Guidelines recommend evaluation of cardiac ejection fraction (EF) every 3 months despite little supporting evidence for this need. We assessed the impact of EF screening on clinical ...

journal_title：Anticancer research

authors： Mescher C,Ding C,Defor T,Konety S,Blaes A

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) class I expression is reportedly frequently reduced in cancer. We examined heat-shock protein (HSP) expression in hepatocellular carcinoma (HCC). PATIENTS AND METHODS:HCV-related HCC was examined in 73 patients who had undergone hepatectomy, and the relationship between HSP70 a...

journal_title：Anticancer research

authors： Yoshida S,Hazama S,Tokuno K,Sakamoto K,Takashima M,Tamesa T,Torigoe T,Sato N,Oka M

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND/AIM:The objective of this study was to determine the molecular and clinicopathological features, as well as the prognosis of patients with endometrial cancer (EC) having prior malignancy (second primary EC: SPEC) compared with those without a history of prior malignancy (first primary EC: FPEC). MATERIALS A...

journal_title：Anticancer research

authors： Haraga J,Nakamura K,Haruma T,Nyuya A,Nagasaka T,Masuyama H

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Circulating nucleosomes, complexes of DNA and histones, are recognized as a potential new diagnostic tool for therapy monitoring of cancer disease and as prognostic marker in other acute diseases. Because many studies are carried out retrospectively on serum samples collected earlier, we tested the stability...

journal_title：Anticancer research

authors： Holdenrieder S,Von Pawel J,Nagel D,Stieber P

更新日期：2010-05-01 00:00:00

abstract：:The pattern of cytoplasmic membrane gangliosides and two cellular features which have been reported to be related to the expression of different membrane gangliosides, namely adhesion to solid substrates and susceptibility to the lytic activity of immune effector cells, have been investigated in drug sensitive A2780 h...

journal_title：Anticancer research

authors： Mazzoni A,Trave F,Fabbri M,Leto G,Ghidoni R

更新日期：1991-11-01 00:00:00

abstract：:The active vitamin D3, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), is now well recognized as a potent regulator of cell proliferation and differentiation in addition to possessing a regulatory effect on calcium and phosphorus metabolism. From research on the synthesis of 1,25(OH)2D3 analogs with the goal of separatin...

journal_title：Anticancer research

authors： Kubodera N,Hatakeyama S

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Mistletoe lectins (ML), the major biologically active components of mistletoe extracts, which are used for adjuvant cancer therapy, induce apoptosis in lymphocytes and tumor cells. In addition, ML at toxic concentrations induce the release of cytokines, but it remains unclear as to whether dying or activated...

journal_title：Anticancer research

authors： Stein GM,Pfüller U,Schietzel M,Büssing A

更新日期：2000-05-01 00:00:00

abstract：:MDL 103,323, an enclomiphene analog, was tested for binding to the estrogen receptor, inhibition of human tumor xenografts and prevention of carcinogen-induced mammary tumors. MDL 103,323 had 5-6 fold greater affinity for the human estrogen receptor than did either tamoxifen or enclomiphene. Consistent with enhanced b...

journal_title：Anticancer research

authors： Bitonti AJ,Baumann RJ,Bush TL,Cashman EA,Wright CL,Prakash NJ

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND/AIM:Trans-hiatal and -cervical approach mediastinoscopic radical esophagectomy (TMrE) for esophageal cancers is a less-invasive procedure and does not require for trans-thoracic approach management. However, some patients suffer from pleural effusion after TMrE. In the present study, we investigated the clin...

journal_title：Anticancer research

authors： Hamada J,Konishi H,Shiozaki A,Fujiwara H,Shoda K,Kosuga T,Kubota T,Okamoto K,Arita T,Morimura R,Murayama Y,Ikoma H,Kuriu Y,Nakanishi M,Otsuji E

更新日期：2018-12-01 00:00:00

abstract：:The use of salvage chemotherapy in advanced non small cell lung cancer (NSCLC) is controversial. However, many patients need to be treated in order to achieve relief of their symptoms. Docetaxel (taxotere) is one of the most active drugs for the treatment of advanced NSCLC and several studies have also shown its effec...

journal_title：Anticancer research

authors： Gridelli C,Frontini L,Barletta E,Rossi A,Barzelloni ML,Scognamiglio F,Guida C,Gatani T,Fiore F,De Bellis M,Marfella A,Manzione L

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Although well-acknowledged in vivo, spontaneous death of cancer cells in vitro is less widely appreciated. MATERIALS AND METHODS:Colony formation was studied in untreated control plates of standard clonogenic assays and measurements of actual and potential doubling times performed in asynchronous cultures o...

journal_title：Anticancer research

authors： Warenius H,Kyritsi L,Grierson I,Howarth A,Seabra L,Jones M,Thomas C,Browning P,White R

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Chemotherapy for collecting duct carcinoma (CDC) has demonstrated only limited efficacy in the advanced setting. The present study evaluated the activity of targeted therapies in metastatic CDC. PATIENTS AND METHODS:We evaluated a cohort of 384 consecutive patients with metastatic renal cell carcinoma (mRCC...

journal_title：Anticancer research

authors： Procopio G,Testa I,Iacovelli R,Grassi P,Verzoni E,Garanzini E,Colecchia M,Torelli T,De Braud F

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND/AIM:Pyruvate kinase M2 (PKM2) is an enzyme that is predominantly overexpressed in various types of cancer. The role of PKM2 in liver fluke-associated cholangiocarcinoma (CCA) remains unclear. This study aimed to investigate the antitumor activity of shikonin, a PKM2 inhibitor, in CCA cells. MATERIALS AND ME...

journal_title：Anticancer research

authors： Thonsri U,Seubwai W,Waraasawapati S,Wongkham S,Boonmars T,Cha'on U,Wongkham C

更新日期：2020-09-01 00:00:00