Abstract:
BACKGROUND:The chronomodulated infusion of 5-FU, FA and oxaliplatin allows a significant increase in dose intensity and antitumor efficacy in patients with metastatic colorectal cancer. Here we investigated if substitution of oxaliplatin with cisplatin produced a similar antitumor activity in previously untreated patients with advanced colorectal cancer. METHODS:We enrolled 21 consecutively evaluated ambulatory patients with metastatic colorectal cancer. Each treatment cycle consisted of a 5-day course of continuous chronomodulated venous infusion of drugs. Daily doses were 600 mg/m2 5-FU, 150 mg/m2 FA (L-form), and 12 mg/m2 cisplatin. The cycles were repeated every 21 days. RESULTS:All patients completed at least 3 cycles. Overall a total number of 105 cycles were administered. One partial response (lasting 3 months) and 13 stable disease (lasting from 3 to 12 months) were observed. The remaining 7 patients had progression of the disease. Hematologic and gastrointestinal toxicity was always < or = G2 in all cycles. CONCLUSIONS:The results of this study discourage the substitution of cisplatin for the more active compound, oxaliplatin, in a chronomodulated schedule of infusion with 5-FU and FA in patients with metastatic colorectal cancer.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Natoli C,Scognamiglio MT,Martino MT,Irtelli L,De Tursi M,Cianchetti E,Mascitelli E,Tinari N,Iacobelli Ssubject
Has Abstractpub_date
2000-03-01 00:00:00pages
1253-6issue
2Beissn
0250-7005issn
1791-7530journal_volume
20pub_type
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journal_title:Anticancer research
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pub_type: 杂志文章
doi:
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pub_type: 临床试验,杂志文章
doi:
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pub_type: 临床试验,杂志文章
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更新日期:1995-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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doi:
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