Abstract:
BACKGROUND:Axillary dissection is routinely conducted for all patients with sentinel node (SN)-positive breast cancer. Metastasis to non SNs is not often found after axillary dissection in patients with SN-positive breast cancer. Thus, we investigated clinicopathological features, including immune cells in peripheral blood, in order to identify factors related to metastasis to non-SNs. PATIENTS AND METHODS:We retrospectively investigated 184 patients with SN-positive disease, treated at our institution during the 2013 through 2018 period. All clinicopathological data were obtained before and during surgery. RESULTS:Metastasis to non SNs was observed in 64 cases (35%). The platelet-to-lymphocyte ratio (PLR) and the number of SN metastases were independent of metastasis to non SNs (p=0.023 and p=0.017, respectively). Patients with metastasis to non SNs had significantly lower PLR and more SN metastases. High lymphocyte number and low platelet number resulted in a low PLR. CONCLUSION:PLR might be a marker of metastasis to non SNs.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Ishizuka Y,Horimoto Y,Nakamura M,Arakawa A,Fujita T,Iijima K,Saito Mdoi
10.21873/anticanres.14445subject
Has Abstractpub_date
2020-08-01 00:00:00pages
4405-4412issue
8eissn
0250-7005issn
1791-7530pii
40/8/4405journal_volume
40pub_type
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journal_title:Anticancer research
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