Abstract:
:The aim of this study was to define the clinical prevalence and rate of malignancy of focal thyroid incidentaloma in a relatively large number of individuals with application of 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) in asymptomatic individuals. The subjects consisted of 4803 physical check-up examinees (2638 men, 2165 women; mean age+/-SD, 52.8+/-9 years old) with non-specific medical history. Whole-body FDG PET was performed on all patients. Focal hypermetabolic areas of thyroid, with an intensity equal to or exceeding the level of FDG uptake in the liver, were considered abnormal and interpreted as thyroid incidentaloma. Among the 4803 FDG PET examinations, thyroid incidentaloma was present in 60 examinations, among which, 50 had further examination with ultrasound-guided fine-needle aspiration (FNA), revealing 43 benign lesions and 7 papillary carcinomas. Of 7 examinees diagnosed with cancer, 2 had lymph nodes metastasis. The mean and standard deviation of standard uptake value (SUV) in benign and carcinoma was 2.6+/-1.01 and 6.7+/-3.66, respectively. Thyroid incidentaloma identified by FDG-PET occurred with a frequency of 1.2% (60/4803). Of the thyroid incidentalomas that underwent FNA and surgery, 14% (7/50) were found to be malignant. It is possible to differentiate benign from carcinoma of thyroid incidentalomas by the increased rate of glycolysis (SUV) in the carcinoma. The small size and moderate FDG uptake of thyroid incidentalomas per se cannot guarantee low risk in incidentally found thyroid cancers.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Chen YK,Ding HJ,Chen KT,Chen YL,Liao AC,Shen YY,Su CT,Kao CHsubject
Has Abstractpub_date
2005-03-01 00:00:00pages
1421-6issue
2Beissn
0250-7005issn
1791-7530journal_volume
25pub_type
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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doi:
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doi:
更新日期:1996-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
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更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章
doi:
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journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
更新日期:2015-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2009-08-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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更新日期:2003-09-01 00:00:00
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更新日期:2007-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
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doi:
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更新日期:2001-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Anticancer research
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更新日期:2001-03-01 00:00:00