Overexpression of kappa-actin alters growth properties of hepatoma cells and predicts poor postoperative prognosis.

abstract：:We investigated the effects of an exogenous cdk inhibitor, butyrolactone-I, on cell growth inhibition, apoptosis induction, and the regulation of apoptosis in pancreatic cancer cells with mutated p53. Cell growth was dose-dependently inhibited by Butyrolactone-I in PANC-1 and AsPC-1 cells. Phosphorylation of pRb and C...

journal_title：Anticancer research

authors： Wada M,Hosotani R,Lee JU,Doi R,Koshiba T,Fujimoto K,Miyamoto Y,Tsuji S,Nakajima S,Okuyama A,Imamura M

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Patients with type 2 diabetes mellitus (T2DM) as well as patients with obesity have increased cancer mortality. In a previous paper we suggested that there was a trend for decreased mortality in obese individuals with T2DM. The aim of the new analyses was to investigate the same relationship after increasing...

journal_title：Anticancer research

authors： Landman GW,Van Hateren KJ,Kleefstra N,Bilo HJ

更新日期：2010-02-01 00:00:00

abstract：:Sentinel lymph node biopsy (SLNB) is currently the suggested axillary staging procedure in patients with early-stage breast cancer (BC) and usually requires intraoperative frozen-section (FS) examination of the removed nodes. However, other techniques, such as touch imprint cytology (IC), real-time reverse transcripta...

journal_title：Anticancer research

authors： Lumachi F,Marino F,Zanella S,Chiara GB,Basso SM

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:S-1, an oral 5-fluorouracil (5-FU)-based medicine that combines tegafur, gimeracil and oteracil potassium is commonly used as an adjuvant chemotherapeutic drug for the treatment of colorectal cancer. PATIENTS AND METHODS:We enrolled 53 patients who underwent curative resection for colorectal cancer and live...

journal_title：Anticancer research

authors： Yamauchi K,Kokuryo T,Yokoyama Y,Uehara K,Yamaguchi J,Nagino M

更新日期：2016-05-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) is prevalently expressed in human medulloblastomas in vivo and in vitro. Blockage of LIF expression or biological function can inhibit in vitro growth and induce differentiation-like phenotypes of medulloblastoma cells (Med-3), suggesting a redifferentiation potential of Med-3 cells wh...

journal_title：Anticancer research

authors： Liu J,Guo L,Luo Y,Li JW,Li H

更新日期：2000-07-01 00:00:00

abstract：:In 1992 The International Registry of Inferior Vena Cava (IVC) Leiomyosarcomas was established to study the pathogenesis and natural history of the tumor and to support the most rational treatment. We collected 218 patients through a literature review and personal communications. We corresponded with several Authors t...

journal_title：Anticancer research

authors： Mingoli A,Cavallaro A,Sapienza P,Di Marzo L,Feldhaus RJ,Cavallari N

更新日期：1996-09-01 00:00:00

abstract：:The in vitro antiproliferative or stimulatory activity of an aqueous mistletoe extract (AME) with a defined content of bioactive mistletoe lectin (ML) was investigated in 6 human tumor cell lines, including two melanomas and leiomyosarcomas, each of which had previously been reported to show evidence of growth stimula...

journal_title：Anticancer research

authors： Burger AM,Mengs U,Kelter G,Schüler JB,Fiebig HH

更新日期：2003-09-01 00:00:00

abstract：:The objective of the present study was to investigate the effect of dietary phytosterols on the growth and metastasis of the human breast cancer MDA-MB-231 cell line xenografted in SCID mice. Two groups of animals were fed AIN-93G diet supplemented with 0.2% cholic acid and 2% sterol (cholesterol or phytosterol mixtur...

journal_title：Anticancer research

authors： Awad AB,Downie A,Fink CS,Kim U

更新日期：2000-03-01 00:00:00

abstract：:The relationship between serum and cytosolic levels of carcinoembryonic (CEA), squamous-cell carcinoma (SCC) and CA125 antigens was determined in 122 patients with non-small cell lung cancer. A pronounced serum-cytosol gradient and a high degree of dispersion in the distribution of serum and cytosol marker concentrati...

journal_title：Anticancer research

authors： Diez M,Pollan M,Maestro ML,Ortega MD,Gomez A,Sanchez-Pernaute A,Torres A,Granell J,Balibrea JL

更新日期：1995-11-01 00:00:00

abstract：:The development of T-lymphocytes (T cells) constitute one of the basic and most vital processes in immunology. Conventional mathematical models, being based on the systems theory, fail to sufficiently distinguish the constituents of thymocytes and are thus of limited significance. On the basis of some well thought-out...

journal_title：Anticancer research

authors： Wang G,Krueger GR,Buja LM

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/AIM:The importance of hadron therapy in the cancer management is growing. We aimed to refine the biological effect detection using a vertebrate model. MATERIALS AND METHODS:Embryos at 24 and 72 h postfertilization were irradiated at the entrance plateau and the mid spread-out Bragg peak of a 150 MeV proton ...

journal_title：Anticancer research

authors： Brunner S,TŐkÉs T,SzabÓ ER,Polanek R,SzabÓ IZ,Reisz Z,GubÁn BK,SzijÁrtÓ AL,Brand M,Hans S,Karsch L,Lessmann E,Pawelke J,SchÜrer M,Beyreuther E,HideghÉty K

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Viscum album agglutinin-1 (VAA-1) is assumed to be the biologically most active ingredient of misteltoe extracts that are often used as adjuvant cancer therapy. To develop new approaches for lung cancer treatment, we evaluated the antineoplastic activity of VAA-1 alone and in combination with other chemother...

journal_title：Anticancer research

authors： Siegle I,Fritz P,McClellan M,Gutzeit S,Mürdter TE

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:The safety and advantages of perioperative autologous blood transfusion (ABT) were evaluated on hepatectomy for hepatocellular carcinoma (HCC). MATERIALS AND METHODS:Blood samples were obtained and stored from 30 patients with HCC. HCC cells were investigated by the presence of AFPmRNA using RT-PCR after st...

journal_title：Anticancer research

authors： Kitagawa K,Taniguchi H,Mugitani T,Koh T,Obayashi T,Kunishima S,Yamaguchi A,Yamagishi H

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Pleomorphic rhabdomyosarcomas of the uterus, mainly occurring in postmenopausal women with leading symptoms of vaginal bleeding and abdominal pain, are very rare malignant tumors of the female genital tract. Due to the inefficiency of the adjuvant therapy, the outcome remains poor in the majority of the repo...

journal_title：Anticancer research

authors： Alavi S,Eckes L,Kratschell R,Taube ET,Rosseck F,Wieners G,Sehouli J

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Medullary thyroid carcinoma (MTC) is a calcitonin-producing tumor of the parafollicular C-cells, accounting for 5-10% of all thyroid tumors. To date, the only effective treatment is the early and total surgical removal of all neoplastic tissue. As the prognosis of patients with advanced MTC, unresectable or ...

journal_title：Anticancer research

authors： Pfragner R,Skofitsch G,Höger H,Jech M,Rinner B,Siegl V,Niederle B,Gnant M,Friedl J,Stift A

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Human herpesviruses types 4 and 6 (EBV, HHV-6) are frequently found in Hodgkin 's disease (HD) and--to a certain extent--in Kikuchi-Fujimoto's disease (KFD). Both viruses are apparently related to proliferative and/or apoptotic processes as represented by HD or KFD respectively. OBJECTIVE:To correlate frequ...

journal_title：Anticancer research

authors： Krueger GR,Huetter ML,Rojo J,Romero M,Cruz-Ortiz H

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND/AIM:Methionine inhibits proliferation of breast and prostate cancer cells. This study aimed to determine cell cycle effects of methionine and selectivity for cancer cells. MATERIALS AND METHODS:MCF-7 (breast), LNCaP (prostate), and LS-174 (colon) cancer cells (wild-type p53), DU-145 (prostate) and SW480 (co...

journal_title：Anticancer research

authors： Benavides MA,Hagen KL,Fang W,Du P,Lin S,Moyer MP,Yang W,Bland KI,Grizzle WE,Bosland MC

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Late developing breast cancer metastases are common and lethal despite treatment with adjuvant chemotherapy at the time of primary tumor excision. Stimulation of an antitumor immune response is an alternative strategy for preventing this devastating development. MATERIALS AND METHODS:A mouse model of the hu...

journal_title：Anticancer research

authors： Gao Y,Bergman I

更新日期：2018-12-01 00:00:00

abstract：:Keishi-ka-kei-to, a traditional Chinese herbal medicine composed of a mixture of crude extracts from five medicinal plants (Cinnamomi cortex, Paeoniae radix, Zizyphi fructus, Zingiberis rhizoma and Glycyrrhizae radix), inhibited experimental pulmonary metastasis in mice implanted with B16F10 melanoma cells. When 136 t...

journal_title：Anticancer research

authors： Suzuki F,Kobayashi M,Komatsu Y,Kato A,Pollard RB

更新日期：1997-03-01 00:00:00

abstract：:This study is related to the serious side effects of Doxorubicin-cardiotoxicity and serum lipid caused by the drug's cumulative effect. Studies were performed on experimental animals treated with intensive administration of Doxorubicin. Seventy five wistar rats were divided in two equal groups A and B. Group A was use...

journal_title：Anticancer research

authors： Samelis GF,Stathopoulos GP,Kotsarelis D,Dontas I,Frangia C,Karayannacos PE

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Studies have recommended a 21-gene recurrence score (RS) to optimize adjuvant treatment for patients with early-stage breast cancer (EBC) with hormone receptor-positive (HR+) and human epidermal growth factor receptor-2 negative (HER2-) tumors. This study aimed to prospectively evaluate the impact of this RS...

journal_title：Anticancer research

authors： Zeng Y,Li Q,Qin T,Li S,Jin L,Wu J,Chen K,Deng H,Rao N,Liu Q,Su F,Jia W,Yao H

更新日期：2017-08-01 00:00:00

abstract：:The role of growth factors in tumour growth and progression has increasingly been studied over the last few years. This review summarizes the available data and discusses their limitations as well as their potential influence on future therapeutic strategies. A large body of data suggests an important role of EGF, TGF...

journal_title：Anticancer research

authors： Nieder C,Schlegel J,Andratschke N,Thamm R,Grosu AL,Molls M

更新日期：2003-03-01 00:00:00

abstract：:Molecular chaperones, many of which are heat-shock proteins (HSPs), are an important class of molecules with various functions. Pathological conditions in which chaperones become etiological and/or pathogenic factors are called chaperonopathies, and are classified into by defect, by excess, and by 'mistake'. In the la...

journal_title：Anticancer research

authors： Rappa F,Farina F,Zummo G,David S,Campanella C,Carini F,Tomasello G,Damiani P,Cappello F,DE Macario EC,Macario AJ

更新日期：2012-12-01 00:00:00

abstract：:In lung cancer patients tumor markers are used for disease monitoring. The goal of this study was to improve diagnostic efficiency in the detection of tumor progression in lung cancer patients by using fuzzy logic modeling in combination with a tumor marker panel (Tumor M2-PK, CYFRA 21-1, CEA, NSE and SCC). Thirty-thr...

journal_title：Anticancer research

authors： Schneider J,Peltri G,Bitterlich N,Neu K,Velcovsky HG,Morr H,Katz N,Eigenbrodt E

更新日期：2003-03-01 00:00:00

abstract：UNLABELLED:The aim of this study was to evaluate the efficacy and safety of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in Japanese patients with relapsed or recurrent advanced non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:This was a multicentre, open-label phase II study of er...

journal_title：Anticancer research

authors： Takahashi T,Yamamoto N,Nukiwa T,Mori K,Tsuboi M,Horai T,Masuda N,Eguchi K,Mitsudomi T,Yokota S,Segawa Y,Ichinose Y,Fukuoka M,Saijo N

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:The etiology of ovarian cancer is not fully understood. Polymorphisms in low penetrance genes involved in carcinogen and estrogen metabolism are hypothesized to play a role in the initiation of carcinogenesis. PATIENTS AND METHODS:A case-control study was conducted to investigate the role of these polymorph...

journal_title：Anticancer research

authors： Delort L,Chalabi N,Satih S,Rabiau N,Kwiatkowski F,Bignon YJ,Bernard-Gallon DJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Extraskeletal myxoid chondrosarcoma (EMC) is a rare malignant soft-tissue tumor and often shows extracompartmental tumoral invasion. The aim of our study was to investigate the clinical features, especially extracompartmental tumoral invasion (ETI) of EMC. PATIENTS AND METHODS:A total of 35 operative patien...

journal_title：Anticancer research

authors： Minami Y,Matsumoto S,Ae K,Tanizawa T,Hayakawa K,Funauchi Y,Saito M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Microparticles are known to be increased in various malignancies. In this prospective study, microparticle levels were evaluated in patients with benign and malignant ovarian lesions. PATIENTS AND METHODS:Microparticles from platelets/megakaryocytes, activated platelets and endothelial cells, tissue factor ...

journal_title：Anticancer research

authors： Rank A,Liebhardt S,Zwirner J,Burges A,Nieuwland R,Toth B

更新日期：2012-05-01 00:00:00

abstract：:Inv(3)(q21q26)/t(3;3)(q21;q26) is a feature of a distinctive entity of acute myeloid leukemia (AML) associated with normal or elevated platelet count, atypical megakaryocytes and multilineage dysplasia in the bone marrow, as well as minimal to no response to chemotherapy and poor clinical outcome. The presence of an i...

journal_title：Anticancer research

authors： De Braekeleer E,Douet-Guilbert N,Le Bris MJ,Ianotto JC,Berthou C,Gueganic N,Bovo C,Basinko A,Morel F,De Braekeleer M

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Chemotherapy is considered to have a marginal impact on survival. The purpose of this study was to evaluate the rate of long-term survival in patients treated with chemotherapy for advanced non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:The case records of 109 patients with NSCLC treated with chem...

journal_title：Anticancer research

authors： Satoh H,Ishikawa H,Ohara G,Kagohashi K,Kurishima K,Ohtsuka M,Hizawa N

更新日期：2007-11-01 00:00:00