Touch imprint cytology and frozen-section analysis for intraoperative evaluation of sentinel nodes in early breast cancer.

abstract：:P-glycoprotein (P-gp) and multidrug resistance related protein (MRP) overexpression is often responsible of the development of multidrug resistance in cancer therapy. These proteins are also expressed in normal tissues, where their physiological role is related to the extrusion of endogenous toxins or to secretory fun...

journal_title：Anticancer research

authors： Rosati A,Decorti G,Klugmann FB,Candussio L,Granzotto M,Melato M,Giraldi T

更新日期：2000-09-01 00:00:00

abstract：:Ovarian tumors of low malignant potential (LMPs) are intermediate between adenomas and ovarian carcinomas (OCs); however, whether an LMP is a precursor of OC or is a unique type of tumor that will not progress to OC is still controversial. To gain better insight into the relationship between LMP and OC, we compared pr...

journal_title：Anticancer research

authors： Nakayama K,Takebayashi Y,Hata K,Fujiwaki R,Iida K,Fukumoto M,Miyazaki K

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Cyclooxygenase-2 (Cox-2) is expressed by several types of epithelial malignancies, i.e., carcinomas, and inhibition of Cox-2 may have a therapeutic role in chemoprevention and treatment of cancer. The role of Cox-2 in non-epithelial malignancies, however, is unclear. MATERIALS AND METHODS:We investigated, b...

journal_title：Anticancer research

authors： Lassus P,Ristimäki A,Huuhtanen R,Tukiainen E,Asko-Seljavaara S,Andersson LC,Miettinen M,Blomqvist C,Haglund C,Böhling T

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:The leptin receptor is involved in modulating leptin activity, acting as a carrier protein. A link between leptin or leptin receptor and cancer development has been proposed and here, the hypothesis that leptin and its receptor might be implicated in colorectal cancer (CRC) progression and invasion was inves...

journal_title：Anticancer research

authors： Tutino V,Notarnicola M,Guerra V,Lorusso D,Caruso MG

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND/AIM:Androgens are essential for the growth of most prostate cancers (PCa). As a result, androgen ablation is the mainstay of the treatment of PCa. Proteins of the polycomb and trithorax family are master epigenetic regulators of cell type specific gene expression including androgen receptor. MATERIALS AND M...

journal_title：Anticancer research

authors： Wang S,Tailor K,Kwabi-Addo B

更新日期：2020-05-01 00:00:00

abstract：:Two rat yolk sac tumour cell lines with different radiosensitivities were used to quantify the extent of apoptosis following irradiation by using a DNA fragmentation assay in vitro. Apoptosis was also confirmed by fluorescence analysis of nuclear morphological changes by using Hoechst 33258. A radiosensitive cell line...

journal_title：Anticancer research

authors： Mitsuhashi N,Ishikawa H,Saito Y,Takahashi T,Sakurai H,Nozaki M,Akimoto T,Hasegawa M,Maebayashi K,Niibe H

更新日期：1997-09-01 00:00:00

abstract：:In this immunohistochemical study we investigated the expression of Bcl-2 and Bax apoptosis related proteins in node-negative breast carcinomas. The results were correlated with the recurrence rate of the patients. In order to avoid the influence of the most important tumor prognostic parameters we selected two groups...

journal_title：Anticancer research

authors： Kapranos N,Karaiosifidi H,Valavanis C,Kouri E,Vasilaros S

更新日期：1997-07-01 00:00:00

abstract：:We investigated the effects of an exogenous cdk inhibitor, butyrolactone-I, on cell growth inhibition, apoptosis induction, and the regulation of apoptosis in pancreatic cancer cells with mutated p53. Cell growth was dose-dependently inhibited by Butyrolactone-I in PANC-1 and AsPC-1 cells. Phosphorylation of pRb and C...

journal_title：Anticancer research

authors： Wada M,Hosotani R,Lee JU,Doi R,Koshiba T,Fujimoto K,Miyamoto Y,Tsuji S,Nakajima S,Okuyama A,Imamura M

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Although oncological results for resection of colon cancer with inferior mesenteric artery (IMA) ligation at its origin (high tie) or immediately below the left colic artery (low tie) are similar, injury of the superior hypogastric plexus may be caused when the IMA is tied at its origin, thus impairing defec...

journal_title：Anticancer research

authors： Fiori E,Crocetti D,Lamazza A,DE Felice F,Scotti GB,Sterpetti AV,Mingoli A,Sapienza P,DE Toma G

更新日期：2020-05-01 00:00:00

abstract：AIM:The aim of this study was to evaluate the ability of tissue polypeptide-specific antigen (TPS), carcinoembryonic antigen (CEA), and cancer antigen 15-3 (CA 15-3) to predict relapse in breast cancer patients, when the measurement of biomarkers is performed within 6 months after surgery. PATIENTS AND METHODS:Four hu...

journal_title：Anticancer research

authors： Svobodova S,Kucera R,Fiala O,Karlikova M,Narsanska A,Zedníková I,Treska V,Slouka D,Rousarova M,Topolcan O,Finek J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Previous reports indicate that the p53 yeast functional assay is a highly sensitive method of detection of p53 mutations in clinical specimens. Our earlier report (1) showed a 35.4% p53 mutation frequency in Hong Kong colorectal carcinoma (CRC) patients, when conventional molecular screening techniques were ...

journal_title：Anticancer research

authors： Leung CS,Lung ML

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The rearrangement of actin cytoskeleton is being increasingly considered a marker of cancer cell activity, but the fine structure and remodeling of microfilaments within tumor tissue still remains unclear. MATERIALS AND METHODS:We used the recently introduced silicon-rhodamine (SiR)-actin dye to visualize e...

journal_title：Anticancer research

authors： Klementieva NV,Snopova LB,Prodanets NN,Furman OE,Dudenkova VV,Zagaynova EV,Lukyanov KA,Mishin AS

更新日期：2016-10-01 00:00:00

abstract：:To identify retinoic acid (RA) signalling pathways involved in growth and differentiation in cells of the glial lineage, two human glioma ceh lines were studied. The three RA receptors (RARs) mRNAs were constitutively expressed, and of the three RXRs, RXR beta appeared predominant. Western blotting analysis confirmed ...

journal_title：Anticancer research

authors： Carpentier AF,Leonard N,Lacombe J,Zassadowski F,Padua RA,Degos L,Daumas-Duport C,Chomienne C

更新日期：1999-07-01 00:00:00

abstract：:We have previously shown that L-glutamic acid gamma-monohydroxamate (GAH) exhibits an antitumor activity, both in vitro and in vivo. In this report we explore the selective cytotoxicity of GAH in vitro by comparing the survival of tumor and normal cells. GAH exerts an irreversible delayed effect with tumoral cells and...

journal_title：Anticancer research

authors： Thomasset N,Chabanas A,Tournaire R,Malley S,Navarro C,Lawrence JJ,Doré JF,Vila J

更新日期：1993-09-01 00:00:00

abstract：AIM:The purpose of this study was to assess the impairment of the submandibular gland, in terms of changes in volume by computed tomography (CT) and CT value, which was the mean pixel value at a region of interest, in a group of patients with head and neck cancer treated with radiation therapy (RT). PATIENTS AND METHO...

journal_title：Anticancer research

authors： Uchiyama Y,Kreiborg S,Murakami S,Tsujimoto T,Sumida I

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Gemcitabine (2'-deoxy-2'-difluorodeoxycytidine: Gemzar) (GEM) appears to be the only effective anticancer drug for pancreatic cancer, but it has little impact on outcome due to a high level of inherent and acquired tumor resistance. Our previous proteomic study demonstrated that the expression of three spots...

journal_title：Anticancer research

authors： Taba K,Kuramitsu Y,Ryozawa S,Yoshida K,Tanaka T,Maehara S,Maehara Y,Sakaida I,Nakamura K

更新日期：2010-07-01 00:00:00

abstract：:A series of simple alpha, beta-unsaturated carbonyl compounds (1-26) was characterized for their cytotoxic profiles against oral human normal and tumor cells. Several cycloalkenones showed potent cytotoxic activities against human oral squamous cell carcinoma HSC-2 cell line. Among them, 4,4-dimethyl-2-cyclopenten-1-o...

journal_title：Anticancer research

authors： Nakayachi T,Yasumoto E,Nakano K,Morshed SR,Hashimoto K,Kikuchi H,Nishikawa H,Kawase M,Sakagami H

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Preclinical studies suggest that 1,25-dihydroxyvitamin D [1,25(OH)2D] and celecoxib inhibit prostaglandins (PGs) associated with cancer through different mechanisms. We determined if there was synergy in their use. PATIENTS AND METHODS:A total of 36 healthy women received daily for one month/menstrual cycle...

journal_title：Anticancer research

authors： Qin W,Smith C,Jensen M,Holick MF,Sauter ER

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The classic Kaposi's sarcoma (KS) patients usually present with progressive skin lesions over the lower extremities, following an indolent course. Although radiotherapy is an effective treatment for KS, radiation over these lesions is not without difficulty. The intrinsic difficulty resides in how a homogeno...

journal_title：Anticancer research

authors： Huang KM,Hsu CH,Jeng SC,Ting LL,Cheng JC,Huang WT

更新日期：2006-01-01 00:00:00

abstract：:Due to their estrogen-mimicking ability, pesticides are considered as prime etiological suspects of increasing tumor incidence, although a direct link is still undefined. The present study aimed to identify the effect of xenoestrogens (lindane, propoxur and endosulfan) at 20 mg/l each on tumorigenesis, by evaluating e...

journal_title：Anticancer research

authors： Bharathi SP,Raj HM,Jain S,Banerjee BD,Ahmed T,Arora VK

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Acquired resistance to platinum-based chemotherapy (Pt-chemo) is a major problem for improving the prognosis for patients with advanced epithelial ovarian cancer (EOC). However, the molecular mechanism of acquired resistance to Pt-chemo is not well understood. MATERIALS AND METHODS:hMLH1 promoter methylatio...

journal_title：Anticancer research

authors： Watanabe Y,Ueda H,Etoh T,Koike E,Fujinami N,Mitsuhashi A,Hoshiai H

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND/AIM:Neoplastic spindle cells (NSCs) are believed to play a role in cancer invasion and metastasis, as well as in poor prognosis. The clinicopathological characteristics and prognostic relevance of NSCs was investigated in gallbladder cancer. MATERIALS AND METHODS:Specimens were obtained from 62 patients wit...

journal_title：Anticancer research

authors： Midorikawa R,Hisaka T,Sakai H,Nomura Y,Goto Y,Sato T,Kawahara R,Ishikawa H,Fujita F,Yasunaga M,Tanigawa M,Naito Y,Akiba J,Yano H,Tanaka H,Akagi Y,Okuda K

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND/AIM:Second mitochondria-derived activator of caspase (Smac) is a proapoptogenic mitochondrial protein that antagonizes inhibitors of apoptosis proteins (IAPs), resulting in induction of apoptosis. In the present study we investigated the effects of a Smac mimetic in combination with doxorubicin against osteo...

journal_title：Anticancer research

authors： Kamata E,Kawamoto T,Ueha T,Hara H,Fukase N,Minoda M,Morishita M,Takemori T,Fujiwara S,Nishida K,Kuroda R,Kurosaka M,Akisue T

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:P-glycoprotein (Pgp), encoded by the ATP-binding cassette B1 (ABCB1) gene, is an efflux transporter located on the luminal side of intestinal epithelial cells, which protects the gut from endogenous and exogenous toxins. The association of two ABCB1 polymorphisms with the occurrence of colon cancer and long-...

journal_title：Anticancer research

authors： De Iudicibus S,De Pellegrin A,Stocco G,Bartoli F,Bussani R,Decorti G

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND/AIM:Curcumin is a promising nutraceutical for chemoprevention of head and neck squamous cell carcinoma (HNSCC). Capsular formulations of curcumin demonstrate low systemic bioavailability. We aimed to determine if curcumin levels were higher in healthy volunteers and cancer patients with microgranular curcumi...

journal_title：Anticancer research

authors： Latimer B,Ekshyyan O,Nathan N,Moore-Medlin T,Rong X,Ma X,Khandelwal A,Christy HT,Abreo F,McClure G,Vanchiere JA,Caldito G,Dugas T,McMartin K,Lian T,Mehta V,Nathan CA

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND/AIM:Many studies have shown an antiproliferative, anti-inflammatory, anti-angiogenetic, and apoptosis-inducing effect of Vitamin D. A vitamin D deficiency has been associated with an increased risk for different types of cancer. This study examined vitamin D 25(OH)D levels in gynaecological cancers in compar...

journal_title：Anticancer research

authors： Kolnsberg L,Riffelmann M,Friedrich M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIM:Since the first description of five pericytomas with the t(7;12)/ACTB-GLI1 fusion gene, only three new tumors were studied by both cytogenetics and molecular techniques. We report here genetic data on another case of this rare tumor. MATERIALS AND METHODS:Cytogenetic, fluorescence in situ hybridization ...

journal_title：Anticancer research

authors： Panagopoulos I,Gorunova L,Rise TV,Andersen K,Micci F,Heim S

更新日期：2020-03-01 00:00:00

abstract：AIM:To examine the relationship between symptomatic radiation pneumonitis and lung dose-volume parameters for patients receiving accelerated partial breast irradiation (APBI) using three dimensional-conformal radiotherapy (3D-CRT). PATIENTS AND METHODS:The prescribed radiation dose was 30 Gy in 5 fractions over 10 day...

journal_title：Anticancer research

authors： Shikama N,Kumazaki YU,Miyazawa K,Miyaura K,Kato S,Nakamura N,Kawamori J,Shimizuguchi T,Saito N,Saeki T

更新日期：2016-05-01 00:00:00

abstract：:MG132, a proteasome inhibitor, has been shown to induce apoptotic cell death through formation of reactive oxygen species (ROS). Here, we evaluated the effects of MG132 on the growth of endothelial cells, especially calf pulmonary artery endothelial cells (CPAECs). MG132 dose-dependently inhibited the growth of CPAECS...

journal_title：Anticancer research

authors： Han YH,Moon HJ,You BR,Yang YM,Kim SZ,Kim SH,Park WH

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The constant overexpression of glycolysis and active mitochondrial function are critical for productive energy required for the immortal proliferation of cancer cells. The genes related to glycolysis and mitochondrial respiration might have some function during stomach carcinogenesis. MATERIALS AND METHODS:...

journal_title：Anticancer research

authors： Rho M,Kim J,Jee CD,Lee YM,Lee HE,Kim MA,Lee HS,Kim WH

更新日期：2007-01-01 00:00:00