An exogenous cdk inhibitor, butyrolactone-I, induces apoptosis with increased Bax/Bcl-2 ratio in p53-mutated pancreatic cancer cells.

abstract：BACKGROUND:Cancer stem cells (CSCs) have a high tumorigenic ability to form patient-derived tumor xenografts (PDXs). PDXs are an attractive pre-clinical model, but gene expression and biological behavior of cancer cells in the tumor will change during establishment and passage of PDXs. MATERIALS AND METHODS:Human colo...

journal_title：Anticancer research

authors： Mukohyama J,Shimono Y,Yamashita K,Sumi Y,Mukohara T,Minami H,Kakeji Y

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Molecular mechanisms responsible for carcinogenesis in upper urinary tract urothelial carcinoma (UUTUC) are not yet clear. This study aimed to examine and correlate the subcellular localization of activin A, maspin, and the androgen receptor (AR) with demographic characteristics, pathological grade, and stag...

journal_title：Anticancer research

authors： Rau KM,Chen YJ,Sun MT,Kang HY

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:The BCL2 proto-oncogene in non-Hodgkin's lymphoma is a dominant inhibitor of apoptosis. The goal of this work was to develop a (177)Lu-labeled anti-BCL2-peptide nucleic acid (PNA) conjugate designed for dual modality NHL therapy, i.e., simultaneous down-regulation of BCL2-mediated resistance to apoptosis and...

journal_title：Anticancer research

authors： Balkin ER,Jia F,Miller WH,Lewis MR

更新日期：2011-10-01 00:00:00

abstract：:Evidence exists that estrogen metabolism has a role in the pathogenesis of recurrent respiratory papillomatosis (RRP). This disease has a papillomavirus etiology and is characterized by recurrent benign tumors with a significant propensity to become malignant. We have measured the systemic transformation of estrogen u...

journal_title：Anticancer research

authors： Auborn K,Abramson A,Bradlow HL,Sepkovic D,Mullooly V

更新日期：1998-11-01 00:00:00

abstract：:A 60-year-old male patient with advanced gastric adenocarcinoma was treated by subtotal gastrectomy with dissection of the regional lymph nodes. Microscopic examination of the tumour revealed tubular adenocarcinoma which invaded the muscularis propria. There was no evidence of metastatic carcinoma in the dissected lym...

journal_title：Anticancer research

authors： Caruso RA,Parisi A,Valerio F,Napoli P,Parisi G

更新日期：2003-09-01 00:00:00

abstract：:We assessed the effect of granulocyte apheresis in patients exhibiting increased granulocyte-to-lymphocyte ratio in order to overcome granulocytosis occurring in the terminal stages of malignancies. 17 patients with post-operative recurrent metastatic tumors including 6 gastric, 3 colonic, 2 rectal, 1 esophageal and 5...

journal_title：Anticancer research

authors： Tabuchi T,Ubukata H,Sato S,Nakata I,Goto Y,Watanabe Y,Hashimoto T,Mizuta T,Adachi M,Soma T

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND/AIM:The identification of a series of oxadiazole-based compounds, as promising antiproliferative agents, has been previously reported. The aim of this study was to explore the SAR of newly-synthesized oxadiazole derivatives and identify their molecular targets. MATERIALS AND METHODS:A small library of 1,2,5...

journal_title：Anticancer research

authors： Gelain A,Mori M,Meneghetti F,Porta F,Basile L,Marverti G,Asai A,Hyeraci M,García-Argáez AN,Via LD,Guccione S,Villa S

更新日期：2019-01-01 00:00:00

abstract：UNLABELLED:The aim of the present study was to evaluate the effectiveness and safety of hepatic re-resection for breast cancer liver metastases. PATIENTS AND METHODS:Between January 2004 and December 2014 seven patients were submitted to liver re-resection for breast cancer liver metastases at our Center. The main inc...

journal_title：Anticancer research

authors： BacalbaȘa N,Balescu I,Dima S,Popescu I

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The optimal treatment for locoregionally recurrent rectal cancer after curative surgery has not yet been defined. The definition of prognostic factors could lead to the selection of an aggressive therapeutic approach in patients with favourable prognosis alone. PATIENTS AND METHODS:The records of thirty-nin...

journal_title：Anticancer research

authors： Pergolizzi S,Settineri N,Santacaterina A,Maisano R,Frosina P,Loria F,Nardella G,Garufi G,Sansotta G,De Renzis C

更新日期：1999-03-01 00:00:00

abstract：:Around 1970 it was assumed that tumour cells are due to a single specific oncogenic mutation. This implied that daily many thousands of tumour cells would arise de novo and that most of these tumour cells were killed by immune surveillance or natural resistance mechanisms. Recent findings on immune surveillance and na...

journal_title：Anticancer research

authors： Den Otter W,Koten JW,Derkinderen DJ

更新日期：1986-05-01 00:00:00

abstract：AIM:To assess outcomes in patients treated with first-line bevacizumab-containing therapy for human epidermal growth factor receptor (HER)2-negative metastatic breast cancer (mBC) at a single centre with a homogenous standard-of-care. PATIENTS AND METHODS:Information on patient and disease characteristics, efficacy, a...

journal_title：Anticancer research

authors： Dieras V,Pop S,Berger F,Dujaric ME,Beuzeboc P,Escalup L,Bidard FC,Cottu PH,LE Tourneau C,Piperno-Neumann S,Laurence V,Robain M,Asselain B,Pierga JY

更新日期：2017-03-01 00:00:00

abstract：:A possible influence of tamoxifen (TAM) treatment on the measurable content of some steroid hormone receptors (i.e. ER, PgR, AR) from primary breast cancers has been evaluated. In eleven postmenopausal women, two biopsies were taken from the same tumor, the first biopsy before starting endocrine treatment, and a secon...

journal_title：Anticancer research

authors： Lundgren S,Søreide JA,Lea OA

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND/AIM:HER2-positive breast cancers eventually relapse in about one third of patients. Is anti-HER2-directed therapy with Herceptin® (trastuzumab) effective in re-treatment? Between 2008 and 2018, 216 patients with recurrent HER2-positive breast cancer (BC) were re-treated with Herceptin (HER) during first-line...

journal_title：Anticancer research

authors： Hanker LC,FÖrster F,SchrÖder J,Grafe A,Hitschold T,Hesse T,Lattrich CR,Rody A

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:In the last few years, several prognostic factors have been investigated in order to identify among patients with completely resected non-small cell lung cancer (NSCLC) subsets at high risk of recurrence. In this context, the actual role of serum tumour markers is still unclear. The aim of this study was to ...

journal_title：Anticancer research

authors： Foa P,Fornier M,Miceli R,Seregni E,Santambrogio L,Nosotti M,Cataldo I,Sala M,Caldiera S,Bombardieri E

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Radiotherapy (RT) with or without chemotherapy (CT) plays an important role as exclusive treatment in patients with head and neck squamous cell cancer (HNSCC). Unfortunately, in some cases, benefit for patients is not recorded and only treatment-related complications are registered. MATERIALS AND METHODS:Da...

journal_title：Anticancer research

authors： Pasqualetti F,Bocci G,Mey V,Menghini V,Montrone S,Cocuzza P,Ferrazza P,Seccia V,Delishaj D,Orlandini C,Fabrini MG,Danesi R

更新日期：2015-01-01 00:00:00

abstract：:In this study, a protein kinase C inhibitor, H-7, was found to potentiate the antiproliferative effects of difluoromethyl ornithine (DFMO), inhibitor of the polyamine biosynthesis, on NIH 3T3 and 3T3/SV40 cells in culture. Incubation of the cells with DFMO inhibited the cell growth, whereas the addition of polyamine s...

journal_title：Anticancer research

authors： Khan NA,Havouis R,Quemener V,Moulinoux JP

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Despite having disseminated cancer, not all patients are eligible for palliative chemotherapy or targeted therapies. AIM:To study reasons for withholding palliative chemotherapy, to survey which alternatives were offered and to study survival outcomes. MATERIALS AND METHODS:Medical records of 346 patients ...

journal_title：Anticancer research

authors： Randén M,Runesdotter S,Strang P

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:The mitochondrial protein translocase of inner mitochondrial membrane 17 homolog A (TIMM17A) has been identified as a biomarker of breast cancer. The present study aimed to investigate the biological role of TIMM17A in human breast cancer cells. MATERIALS AND METHODS:Anti-TIMM17A transgenes were stably tran...

journal_title：Anticancer research

authors： Yang X,Si Y,Tao T,Martin TA,Cheng S,Yu H,Li J,He J,Jiang WG

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. MATERIALS AND METHODS:Pyrosequencing and ancestry informative mar...

journal_title：Anticancer research

authors： Apprey V,Wang S,Tang W,Kittles RA,Southerland WM,Ittmann M,Kwabi-Addo B

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIM:Vimentin expression in epithelial cells is reported to be associated with the malignant phenotype of cancer cells in vitro. However, the clinical significance of vimentin expression in carcinomas is not well understood. The aim of this study was to clarify the significance of vimentin-positive gastric ca...

journal_title：Anticancer research

authors： Fuyuhiro Y,Yashiro M,Noda S,Kashiwagi S,Matsuoka J,Doi Y,Kato Y,Kubo N,Ohira M,Hirakawa K

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND/AIM:The mechanism responsible for B-cell translocation gene 1 (BTG1) down-regulation in breast carcinoma remains unknown. We examined the BTG1 expression status in breast carcinoma cells and investigated the mechanism underlying the observed alterations. MATERIALS AND METHODS:Four breast carcinoma cell line...

journal_title：Anticancer research

authors： Woo HY,DO SI,Kim SH,Song SY,Kim HS

更新日期：2019-10-01 00:00:00

abstract：:The cytosol hormone receptors were extracted from rabbit uteri and human tumors with tris buffer systems for three consecutive homogenization and centrifugation processes to obtain three cytosols C-1, C-2, and C-3. The assay results evaluated revealed that minimal to tremendous amounts of receptor activities were pres...

journal_title：Anticancer research

authors： Chen YM,Rice RG,Vaughn CB

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase 9 (MMP-9) plays an important role in cancer invasion and metastasis. The relationship between serum MMP-9 levels and clinicopathological factors in gastric cancer patients is not clear. MATERIALS AND METHODS:Preoperative serum was obtained from 170 patients who had undergone gastrec...

journal_title：Anticancer research

authors： Shen KH,Chi CW,Lo SS,Kao HL,Lui WY,Wu CW

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Combination chemotherapy of irinotecan and amrubicin for advanced non-small cell lung cancer (NSCLC) has not been fully evaluated. To determine the maximum-tolerated dose (MTD), a phase I study in patients with advanced NSCLC was conducted. MATERIALS AND METHODS:Patients with stage IIIB/IV NSCLC were enroll...

journal_title：Anticancer research

authors： Hotta K,Takigawa N,Kiura K,Tabata M,Umemura S,Ogino A,Uchida A,Bessho A,Segawa Y,Shinkai T,Nogami N,Harita S,Okimoto N,Ueoka H,Tanimoto M

更新日期：2005-05-01 00:00:00

abstract：:In a previous study we demonstrated spontaneous fragility and hypersensitivity to fragile site induction by aphidicolin in lymphocytes from some neuroblastoma patients and their parents. Here we report data based on a total of 40 patients and 37 families. Possible correlations between higher sensitivity to aphidicolin...

journal_title：Anticancer research

authors： Vernole P,Tedeschi B,Melino G,Pianca C,Nicoletti B

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Postoperative pancreatic fistula (POPF) remains a major complication after pancreaticoduodenectomy (PD), and the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) after PD is poor. PATIENTS AND METHODS:A multi-institutional retrospective study was performed in 174 patients who underwent PD ...

journal_title：Anticancer research

authors： Yamashita Y,Yoshizumi T,Fukuzawa K,Nishizaki T,Tsujita E,Kajiyama K,Soejima Y,Yamagata M,Yamamoto K,Adachi E,Sugimachi K,Ikeda Y,Uchiyama H,Maeda T,Itoh S,Harimoto N,Ikegami T,Maehara Y

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The constant overexpression of glycolysis and active mitochondrial function are critical for productive energy required for the immortal proliferation of cancer cells. The genes related to glycolysis and mitochondrial respiration might have some function during stomach carcinogenesis. MATERIALS AND METHODS:...

journal_title：Anticancer research

authors： Rho M,Kim J,Jee CD,Lee YM,Lee HE,Kim MA,Lee HS,Kim WH

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Wilms' tumor 1 (WT1) gene has different functional properties depending on the isoform type. This gene correlates with cell proliferation in various types of cancer. Here, we investigated the expression of WT1 isoforms in breast cancer tissues, and focused on the oncogenic role through estrogen receptor-alph...

journal_title：Anticancer research

authors： Nasomyon T,Samphao S,Sangkhathat S,Mahattanobon S,Graidist P

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Immunotherapy has become an attractive new strategy in the treatment of cancer. The laboratory and clinical study of cancer immunotherapy is rapidly advancing. However, in the clinical setting, the results of cancer immunotherapy are mixed. We therefore contend that cancer immunotherapy should be customized ...

journal_title：Anticancer research

authors： Inui T,Kuchiike D,Kubo K,Mette M,Uto Y,Hori H,Sakamoto N

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Oleanolic acid is a triterpenoid that has shown in vitro cytotoxic activity against human tumour cells and is known to be present in many higher plants. MATERIALS AND METHODS:Oleanolic acid is known to have some biological potential including anticancer property. Oleanolic acid was isolated from the ethyl a...

journal_title：Anticancer research

authors： Oyedeji OO,Shode FO,Oyedeji AO,Songca SP,Gwebu ET,Hill GM,Setzer WN

更新日期：2014-08-01 00:00:00