Abstract：
BACKGROUND/AIM:Vimentin expression in epithelial cells is reported to be associated with the malignant phenotype of cancer cells in vitro. However, the clinical significance of vimentin expression in carcinomas is not well understood. The aim of this study was to clarify the significance of vimentin-positive gastric cancer (GC). PATIENTS AND METHODS:A total of 265 GCs were examined by immunofluorescent staining with antibodies against vimentin and carcinoembryonic antigen. GCs were determined to be vimentin-positive when cells were positive for both vimentin and carcinoembryonic antigen staining. RESULTS:A total of 86 (32%) of 265 GCs were vimentin positive. There was a statistically significant correlation between vimentin-positive GCs and advanced clinical stage (p<0.001), macroscopic scirrhous-type (p < 0.001), histological diffuse-type (p < 0.001), lymph node metastasis (p = 0.008) and lymphatic invasion (p = 0.013). The prognosis of patients with vimentin-positive GCs was significantly (p < 0.001) worse than that with vimentin-negative GCs. CONCLUSION:Vimentin expression might contribute to the high invasive phenotype of GC, and may be a useful biomarker to determine the biological aggressiveness of GC.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Fuyuhiro Y,Yashiro M,Noda S,Kashiwagi S,Matsuoka J,Doi Y,Kato Y,Kubo N,Ohira M,Hirakawa Ksubject
Has Abstractpub_date
2010-12-01 00:00:00pages
5239-43issue
12eissn
0250-7005issn
1791-7530pii
30/12/5239journal_volume
30pub_type
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doi：
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doi：
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doi：
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doi：
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