Abstract：
BACKGROUND:The constant overexpression of glycolysis and active mitochondrial function are critical for productive energy required for the immortal proliferation of cancer cells. The genes related to glycolysis and mitochondrial respiration might have some function during stomach carcinogenesis. MATERIALS AND METHODS:The expression of hexokinase 2 (HK2), Bcl-2 and several mitochondria-related gene products were investigated by immunohistochemistry in 257 consecutive human gastric carcinomas, and the results were compared with the clinicopathological characteristics. In addition, transcriptional change of HK2 and Bcl-2 was investigated in the hypoxic state or with mitochondrial inhibitors. RESULTS:In immunohistochemical analysis, HK2 was overexpressed in 43 out of 257 stomach cancer patients. Bcl-2 was not expressed in cases with HK2 positive cancer tissues except for one case, while the voltage-dependent anion channel, complex II and pyruvate dehydrogenase, located in mitochondria, were expressed in all cases. The patients with HK2 expression showed a worse prognosis compared to the HK2 negative cases, and patients who were negative in Bcl-2 and positive in HK2 represented the lowest survival rate. HK2 and Bcl-2 responded to hypoxia, but not to mitochondrial dysfunction while the cellular growth was severely repressed by mitochondrial inhibitors, indicating that transcriptional regulation of HK2 and Bcl-2 proceeds upstream of dysfunctional mitochondria. CONCLUSION:HK2 was overexpressed in 16.7% of gastric carcinomas, and reciprocal expression pattern with Bcl-2. The HK2 positive cases showed a worse prognosis and aggressive character.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Rho M,Kim J,Jee CD,Lee YM,Lee HE,Kim MA,Lee HS,Kim WHsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
251-8issue
1Aeissn
0250-7005issn
1791-7530journal_volume
27pub_type
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journal_title：Anticancer research
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更新日期：2012-02-01 00:00:00
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journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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pub_type： 历史文章,杂志文章
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journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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doi：
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journal_title：Anticancer research
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doi：
更新日期：2013-04-01 00:00:00
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doi：
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doi：
更新日期：2014-01-01 00:00:00
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doi：
更新日期：2013-06-01 00:00:00
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doi：
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更新日期：2004-09-01 00:00:00
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更新日期：2017-02-01 00:00:00
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doi：
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pub_type： 杂志文章
doi：
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journal_title：Anticancer research
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更新日期：2010-04-01 00:00:00
