R-verapamil decreases anti-estrogen resistance in a breast cancer model.

Abstract:

:Drug resistance eventually limits the effectiveness of antiestrogens in breast cancer treatment. Pharmacological reversal of this refractoriness has been attempted with R-Verapamil, a well tolerated calcium channel blocker. This drug significantly decreased the incidence of lung foci after intravenous seeding of the R3230AC rat adenocarcinoma; this effect was correlated with reduction in the expression of P-glycoprotein. The simultaneous administration of antiestrogens with a non-toxic enantiomer of Verapamil was beneficial in the tumour model investigated.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Kellen JA,Wong A,Georges E,Ling V

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

809-11

issue

2

eissn

0250-7005

issn

1791-7530

journal_volume

11

pub_type

杂志文章
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    authors: Ito H,Satoh K,Hamada S,Hirota M,Kanno A,Ishida K,Unno J,Masamune A,Katayose Y,Unno M,Shimosegawa T

    更新日期:2011-03-01 00:00:00

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    doi:

    authors: Morrison DG,Pauly DF,Berdan RC,Dishart MK,Turner DS,Oborn CJ,Medina D

    更新日期:1988-01-01 00:00:00

  • Polyunsaturated fatty acids modulate fibroblast growth in culture.

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    pub_type: 杂志文章

    doi:

    authors: Davidson BC,Girao LA,Giangregorio A,Murphy J

    更新日期:1991-01-01 00:00:00

  • Preoperative Albumin-Bilirubin Grade as a Useful Prognostic Indicator in Patients With Pancreatic Cancer.

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    doi:10.21873/anticanres.13260

    authors: Yagyu T,Saito H,Sakamoto T,Uchinaka EI,Morimoto M,Amisaki M,Watanabe J,Tokuyasu N,Honjo S,Ashida K,Fujiwara Y

    更新日期:2019-03-01 00:00:00

  • CA125 based diagnosis and therapy in recurrent ovarian cancer.

    abstract::Approximately 85% of patients with advanced ovarian cancer will experience recurrence of the disease. In 311 patients CA125 serum levels were determined at follow up investigation in our department. A sensitivity of 92% and specificity of 89% were calculated. Reflecting the further course of disease, specificity could...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Meier W,Baumgartner L,Stieber P,Hasholzner U,Fateh-Moghadam A

    更新日期:1997-07-01 00:00:00

  • Radical external beam radiotherapy for clinically localized prostate cancer in Japan: changing trends in the patterns of care process survey between 1996-1998 and 1999-2001.

    abstract:BACKGROUND:This report presents results of a study delineating changing trends in radical external beam radiotherapy usage for prostate cancer between the 1996-1998 and 1999-2001 Patterns of Care Study (PCS) survey periods in Japan. MATERIALS AND METHODS:Out of the 694 patients comprising the 1996-1998 and 1999-2001 P...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Ogawa K,Nakamura K,Onishi H,Sasaki T,Koizumi M,Shioyama Y,Komiyama T,Miyabe Y,Teshima T,Japanese Patterns of Care Study Working Subgroup of Prostate Cancer.

    更新日期:2005-09-01 00:00:00

  • Effect of genetic polymorphisms related to DNA repair and the xenobiotic pathway on the prognosis and survival of gastric cancer patients.

    abstract:BACKGROUND:A number of association studies have focused on the effect of polymorphisms related to DNA repair or the xenobiotic pathway, on the susceptibility to gastric cancer (GC). Here, the possible association between common polymorphisms in the X-ray repair cross-complementing groups (XRCC) 1, and glutathione-S-tra...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Tahara T,Shibata T,Nakamura M,Yamashita H,Yoshioka D,Okubo M,Yonemura J,Ishizuka T,Maruyama N,Kamano T,Kamiya Y,Fujita H,Nakagawa Y,Nagasaka M,Iwata M,Yamada H,Hirata I,Arisawa T

    更新日期:2011-02-01 00:00:00

  • Lobarstin enhances chemosensitivity in human glioblastoma T98G cells.

    abstract:BACKGROUND/AIM:Lobarstin is a metabolite occurring from the Antarctic lichen Stereocaulon alpnum. Human glioblastoma is highly resistant to chemotherapy with temozolomide. Lobarstin was examined for its effect on glioblastoma. MATERIALS AND METHODS:Temozolomide-resistant T98G cells were subjected to toxicity test with...

    journal_title:Anticancer research

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    doi:

    authors: Kim S,Jo S,Lee H,Kim TU,Kim IC,Yim JH,Chung H

    更新日期:2013-12-01 00:00:00

  • Antiproliferative effects of four different cytokines on renal carcinoma cell lines.

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    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Buszello H

    更新日期:1995-05-01 00:00:00

  • Hras1 VNTR alleles as susceptibility markers for lung cancer: relationship to microsatellite instability in tumors.

    abstract:PURPOSE:To further evaluate lung cancer risk associated with rare Hras1 VNTR alleles and possible biological mechanisms. MATERIALS AND METHODS:The Hras1 VNTR was genotyped in 295 lung cancer patients and 500 healthy controls by PCR and high resolution electrophoresis. Microsatellite alterations were examined in 168 tu...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Lindstedt BA,Ryberg D,Zienolddiny S,Khan H,Haugen A

    更新日期:1999-11-01 00:00:00

  • Antitumor Activity of Novel Bone-seeking, α-emitting 224Ra-solution in a Breast Cancer Skeletal Metastases Model.

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    doi:10.21873/anticanres.12432

    authors: Juzeniene A,Bernoulli J,Suominen M,Halleen J,Larsen RH

    更新日期:2018-04-01 00:00:00

  • Microvascular Invasion in Small-sized Hepatocellular Carcinoma: Significance for Outcomes Following Hepatectomy and Radiofrequency Ablation.

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    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12322

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    更新日期:2018-02-01 00:00:00

  • Correlation of clinical outcome with p53 and p21 status in patients with advanced transitional-cell carcinoma treated with paclitaxel and carboplatin.

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    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Flamm M,Brodowicz T,Haitel A,Susani M,Tomek S,Köstler W,Pycha A,Kratzik C,Marberger M,Zielinski CC

    更新日期:2002-03-01 00:00:00

  • Adriamycin resistance modulation induced by lonidamine in human breast cancer cells.

    abstract::The effect of Lonidamine (LND), an energolytic chemosensitizing agent, on the MDR (multidrug resistant) phenotype of a human breast cancer cell line (MCF-7) has been studied. The intracellular adriamycin (ADR) accumulation and distribution, the plasma membrane potential and the P170 glycoprotein phosphorylation, have ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Zupi G,Molinari A,D'Agnano I,Meschini S,Del Bufalo D,Matarrese P,Candiloro A,Calcabrini A,Citro G,Arancia G

    更新日期:1995-11-01 00:00:00

  • Immunization with TGF-beta antisense oligonucleotide-modified autologous tumor vaccine enhances the antitumor immunity of MBT-2 tumor-bearing mice through upregulation of MHC class I and Fas expressions.

    abstract::The major purpose of this study was to define if the immunosuppressive effect of a transforming growth factor-beta (TGF-beta)-producing autologous tumor vaccine can be abrogated and rendered immunogenic by suppressing its TGF-beta secretion with antisense strategy. In this study, using a TGF-beta antisense gene modifi...

    journal_title:Anticancer research

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    doi:

    authors: Tzai TS,Shiau AL,Liu LL,Wu CL

    更新日期:2000-05-01 00:00:00

  • Serum dehydroepiandrosterone and dehydroepiandrosterone sulfate and risk of melanoma or squamous cell carcinoma of the skin.

    abstract:BACKGROUND:Dehydroepiandrosterone (DHEA) and its analogs have potent chemoprotective actions in mouse skin tumorigenesis models. To assess this association in humans, we investigated the relationship of prediagnostic serum concentrations of DHEA and dehydroepiandrosterone sulfate (DHEAS) to the subsequent risk of devel...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Alberg AJ,Gordon GB,Genkinger JM,Hoffman SC,Selvin E,Comstock GW,Helzlsouer KJ

    更新日期:2001-11-01 00:00:00

  • Relation between carcinogenesis, chromatin structure and poly(ADP-ribosylation) (review).

    abstract::Poly(ADP-ribose) is a naturally occurring nuclear macromolecule resembling nucleic acids. It is synthesized from NAD+ on histones and a few other nuclear proteins. Its function, although not completely understood, might be to alter chromatin structure and to regulate the activity of proteins involved in the metabolism...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Boulikas T

    更新日期:1991-03-01 00:00:00

  • Mutated in colorectal cancer protein modulates the NFκB pathway.

    abstract:BACKGROUND:The tumour suppressor gene 'mutated in colorectal cancer' (MCC) is silenced through promoter methylation in colorectal cancer and has been implicated as a regulator of the nuclear factor kappa B (NFκB) pathway. Therefore, we aimed to determine whether MCC modulates NFκB activation in colorectal cancer. MATE...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Sigglekow ND,Pangon L,Brummer T,Molloy M,Hawkins NJ,Ward RL,Musgrove EA,Kohonen-Corish MR

    更新日期:2012-01-01 00:00:00

  • 5q-: pathogenetic importance of the common deleted region and clinical consequences of the entire deleted segment.

    abstract::Partial deletion of chromosome 5q (5q-) is a frequent aberration in myelodysplasias and acute nonlymphocytic leukemias. It causes clinical and hematological symptoms termed the 5q-syndrome. Although more than 30 different 5q deletions are described, recent studies have demonstrated 5q31 as the common deleted region an...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Pedersen B

    更新日期:1993-09-01 00:00:00

  • Cell cycle arrest and apoptosis induced by oxaliplatin (L-OHP) on four human cancer cell lines.

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    journal_title:Anticancer research

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    doi:

    authors: William-Faltaos S,Rouillard D,Lechat P,Bastian G

    更新日期:2006-05-01 00:00:00

  • The p53-stabilizing compound, CP-31398, does not enhance chemosensitivity in human melanoma cells.

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    pub_type: 杂志文章

    doi:

    authors: Luu Y,Li G

    更新日期:2003-01-01 00:00:00

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    pub_type: 杂志文章

    doi:

    authors: Lea MA,Chacko J,Bolikal S,Hong JY,Chung R,Ortega A,desbordes C

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  • Exposure to sorbitol induces resistance to cisplatin in human non-small-cell lung cancer cell lines.

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    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Bando T,Fujimura M,Kasahara K,Shibata K,Shirasaki H,Heki U,Iwasa K,Ueda A,Tomikawa S,Matsuda T

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  • Pentafecta Outcomes of 230 Cases of Robotic-assisted Radical Prostatectomy with Bilateral Neurovascular Bundle Preservation.

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    doi:

    authors: Ou YC,Yang CK,Kang HM,Chang KS,Wang J,Hung SW,Tung MC,Tewari AK,Patel VR

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    pub_type: 杂志文章

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    doi:

    authors: Sonabend AM,Rolle CE,Lesniak MS

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    doi:

    authors: Levy RD,Oosthuizen MM,Degiannis E,Lambrechts H

    更新日期:1998-03-01 00:00:00