Abstract：
BACKGROUND:This study aimed to elucidate the prognostic value of vimentin expression in patients with intrahepatic cholangiocarcinoma (ICC). PATIENTS AND METHODS:A retrospective analysis of 21 patients who underwent resection for ICC was conducted. Vimentin expression was positive when single tumour cells or cell clusters showed immunoreactivity to vimentin, whereas vimentin-negative expression was defined as no detectable expression. RESULTS:Of the 21 patients, 5 were classified as having tumours with vimentin-positive expression and 16 with vimentin-negative expression. Vimentin-positive expression was more frequent in tumour specimens that were poorly differentiated (4/7; 57%) than in those that were well- or moderately differentiated (1/14; 7%, p=0.025) and was always seen in areas with the highest histological grade. Vimentin-positive expression affected survival adversely, according to univariate (p=0.010) and multivariate analyses (relative risk, 4.294; p=0.047). CONCLUSION:Vimentin-positive expression correlates with dedifferentiation and predicts poor survival in patients undergoing resection for ICC.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Korita PV,Wakai T,Ajioka Y,Inoue M,Takamura M,Shirai Y,Hatakeyama Ksubject
Has Abstractpub_date
2010-06-01 00:00:00pages
2279-85issue
6eissn
0250-7005issn
1791-7530pii
30/6/2279journal_volume
30pub_type
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