Inhibition of invasion of MCF-7/6 human breast carcinoma cells in vitro by Methanobacterium thermoautotrophicum extract.

abstract：UNLABELLED:The aim of the present study was to investigate hypoxia-inducible factor 1α (HIF-1α) and glucose transporter-1 (GLUT-1) expressions as predictors of response and survival after chemoradiotherapy in pretreatment biopsy specimens from patients with rectal cancer. MATERIALS AND METHODS:The immunohistological e...

journal_title：Anticancer research

authors： Havelund BM,Sørensen FB,Lindebjerg J,Spindler KL,Jakobsen A

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:It was recently reported that expression of prospero homeobox protein-1 (PROX1) is correlated with the prognosis of esophageal cancer and colorectal cancer. However, its correlation with gastric cancer is unclear. MATERIALS AND METHODS:Our study analyzed the effect of PROX1 knockdown on the migration, invas...

journal_title：Anticancer research

authors： Ueta K,Otowa Y,Kakeji Y,Hirashima M

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) play a key role in extracellular matrix (ECM) turnover and remodeling. Changes in their expression levels have been observed in various tumor types. However, their clinical significance and prognostic importance in the progr...

journal_title：Anticancer research

authors： Honkavuori M,Talvensaari-Mattila A,Puistola U,Turpeenniemi-Hujanen T,Santala M

更新日期：2008-09-01 00:00:00

abstract：AIM:To compare a new-generation fecal immunochemical test (FIT) with the leading guaiac-based test in detection of fecal occult blood (FOB) in colonoscopy-referral patients. PATIENTS AND METHODS:A cohort of 300 patients referred for colonoscopy was examined by two different tests for FOB: ColonView quick test (CV) (FI...

journal_title：Anticancer research

authors： Vasilyev S,Smirnova E,Popov D,Semenov A,Eklund C,Hendolin P,Paloheimo L,Syrjänen K

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:This study aimed to examine the effect of apigenin on proliferation and apoptosis in HER2-overexpressing MDA-MB-453 breast cancer cells. MATERIALS AND METHODS:The antiproliferative effects of apigenin were examined by proliferation and MTT assays. The effect of apigenin on apoptotic molecules was determined...

journal_title：Anticancer research

authors： Seo HS,Ku JM,Choi HS,Woo JK,Jang BH,Shin YC,Ko SG

更新日期：2014-06-01 00:00:00

abstract：:We have previously shown biopsies from human malignant melanoma, as well as a cell line (MELUR) derived from human malignant melanoma cells, to contain dexamethasone (DEX) - and medroxyprogesterone acetate (MPA) - binding macromolecules exhibiting properties of glucocorticoid receptors from well-known target organs. I...

journal_title：Anticancer research

authors： Bojar H,Fabry W

更新日期：1985-03-01 00:00:00

abstract：:In this study the unexpected findings from the analysis of 278 breast cancer tissue specimens are reported. A surprising strongly positive correlation between an unfavourable and a favourable prognosis with markers cathepsin D and pS2 respectively, was revealed by linear regression analysis (Pearson, Student-T-Test). ...

journal_title：Anticancer research

authors： Ardavanis A,Gerakini F,Amanatidou A,Scorilas A,Pateras C,Garoufali A,Pissakas G,Stravolemos K,Apostolikas N,Yiotis I

更新日期：1997-09-01 00:00:00

abstract：:The 5-year survival of colorectal cancer patients with distant metastases is below 30%, despite the development and use of a variety of chemotherapeutic regimens. Therefore, new therapeutic strategies are warranted. Whereas radioimmunotherapy (RIT) has shown disappointing results in bulky disease, it may be a promisin...

journal_title：Anticancer research

authors： Behr TM,Memtsoudis S,Vougioukas V,Liersch T,Gratz S,Schmidt F,Lorf T,Post S,Wörmann B,Hiddemann W,Ringe B,Becker W

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND/AIM:Advanced anaplastic thyroid cancer (ATC) is a rare, but highly aggressive malignancy, and its prognostic factors need to be further explored. We examined socioeconomic factors' predictive effect for survival performance in stage IV ATC patients. MATERIALS AND METHODS:Using the Surveillance, Epidemiology...

journal_title：Anticancer research

authors： Li MU,Gu S,Mao R,Ning Y,Trivedi N,Siddiqui A,Li P,Huo L

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND/AIM:Diffusion-weighted imaging (DWI) allows for differentiation of benign from malignant tumors, histological tumor types and their grade. The aim of the study was to evaluate the capabilities of DWI using 3 Tesla Magnetic resonance imaging (3T MRI) in the preoperative assessment of renal tumors. PATIENTS A...

journal_title：Anticancer research

authors： Mirka H,Korcakova E,Kastner J,Hora M,Hes O,Hosek P,Ferda J

更新日期：2015-04-01 00:00:00

abstract：:Almost all individuals with neurofibromatosis type 1 (NF1) develop peripheral nerve sheath tumors (PNSTs), mainly benign neurofibromas, however about 10% of PNSTs will undergo transformation to malignant peripheral nerve sheath tumors (MPNSTs). Surgical treatment of PNSTs has traditionally been regarded as a standard ...

journal_title：Anticancer research

authors： Marjanska A,Galazka P,Wysocki M,Styczynski J

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:S-1, an oral 5-fluorouracil (5-FU)-based medicine that combines tegafur, gimeracil and oteracil potassium is commonly used as an adjuvant chemotherapeutic drug for the treatment of colorectal cancer. PATIENTS AND METHODS:We enrolled 53 patients who underwent curative resection for colorectal cancer and live...

journal_title：Anticancer research

authors： Yamauchi K,Kokuryo T,Yokoyama Y,Uehara K,Yamaguchi J,Nagino M

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The frequency of epithelial cell adhesion molecule (EpCAM) expression was investigated in non-small cell lung cancer (NSCLC) cells and human tissues, and its clinicopathological significance in adenocarcinoma of the lung was evaluated. MATERIALS AND METHODS:EpCAM expression was analysed by reverse transcrip...

journal_title：Anticancer research

authors： Kim Y,Kim HS,Cui ZY,Lee HS,Ahn JS,Park CK,Park K,Ahn MJ

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:PS2-expression is controlled by estrogens and is a prognostic factor for long-term and post-relapse survival. Breast carcinomas associated with a BRCA1 mutation (BRCA1-BC'S) exhibit many specific features, particularly for ER expression. Our purpose was to determine if pS2-expression was different in BRCA1-B...

journal_title：Anticancer research

authors： Charafe-Jauffre E,Eisinger F,Mathoulin-Portier MP,Sobol H,Jacquemier J

更新日期：2001-07-01 00:00:00

abstract：:The option to treat patients presenting with HER-2 overexpressed invasive breast carcinoma with Herceptin requires quantitative determination of the HER-2 status. The aim of this study was to retrospectively evaluate the HER-2 mRNA expression levels using quantitative real-time RT-PCR (Q-RT-PCR) in tissue samples from...

journal_title：Anticancer research

authors： Bossard C,Bieche I,Le Doussal V,Lidereau R,Sabourin JC

更新日期：2005-11-01 00:00:00

abstract：AIM:The aim of this study was to evaluate the ability of tissue polypeptide-specific antigen (TPS), carcinoembryonic antigen (CEA), and cancer antigen 15-3 (CA 15-3) to predict relapse in breast cancer patients, when the measurement of biomarkers is performed within 6 months after surgery. PATIENTS AND METHODS:Four hu...

journal_title：Anticancer research

authors： Svobodova S,Kucera R,Fiala O,Karlikova M,Narsanska A,Zedníková I,Treska V,Slouka D,Rousarova M,Topolcan O,Finek J

更新日期：2018-01-01 00:00:00

abstract：:An MCF-7 human breast cancer line variant (MCF-7/MPA), resistant to medroxyprogesterone-acetate (MPA), was obtained by continuous exposure in vitro to the drug. MCF-7/MPA cells were grown in the presence of 12.5 x 10(-6) M MPA and were selected by increasing the concentration of the drug in the growth medium in a step...

journal_title：Anticancer research

authors： Gibelli N,Zibera C,Sica G,Carbone M,Pedrazzoli P,Robustelli della Cuna G

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the efficacy of anticoagulant fondaparinux postoperatively for preventing recurrence after curative resection of colorectal cancer with lymphnode metastasis. PATIENTS AND METHODS:The records of 279 patients who underwent curative resection of colorectal cancer with l...

journal_title：Anticancer research

authors： Yamaoka Y,Ikeda M,Ikenaga M,Murakami H,Haraguchi N,Miyake M,Yamamoto K,Asaoka T,Nishikawa K,Miyamoto A,Miyazaki M,Hirao M,Nakamori S,Sekimoto M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Cisplatin-based chemotherapy seems to improve the control of non-small cell lung cancer (NSCLC)-related symptoms, but assessment of symptomatic gain in these patients is often difficult. This study was designed to test a method for the assessment of clinical benefit in elderly advanced NSCLC patients, after ...

journal_title：Anticancer research

authors： Lippe P,Silva RR,Giuliodori L,Monterubbianesi MC,Mattioli R,Massacesi C,Cascinu S,Tummarello D,Cellerino R

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Cyclooxygenase (COX) is a key enzyme in the conversion of arachidonic acid to prostaglandins and other eicosanoids. A recent report has indicated a selective COX-2 inhibitor resulted in increased apoptosis and down-regulated bcl-2 expression in the androgen-sensitive human prostate cancer cell. We investigat...

journal_title：Anticancer research

authors： Tanji N,Kikugawa T,Yokoyama M

更新日期：2000-07-01 00:00:00

abstract：:Mutations affecting the mechanistic target of rapamycin (MTOR) signalling pathway are frequent in human cancer and have been identified in up to 15% of pancreatic neuroendocrine tumours (NETs). Grade A evidence supports the efficacy of MTOR inhibition with everolimus in pancreatic NETs. Although a significant proporti...

journal_title：Anticancer research

authors： Backman S,Norlén O,Eriksson B,Skogseid B,Stålberg P,Crona J

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Resistance to multiple chemotherapeutic agents results from a variety of factors including a lack of apoptosis in tumor cells. To induce apoptosis in two types of tumor cells, RPMI-8226 and MG-63, a combination of chemotherapeutic agents and retroviral transduction of TRAIL was employed. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Suzuki H,Hotta T,Koyama T,Komagata M,Imakiire A,Yanase N,Yoshimoto T,Mizuguchi J

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND/AIM:4H-1-Benzopyran-4-ones (chromones) provide a backbone structure for the chemical synthesis of potent anticancer drugs. In contrast to 2-(N-cyclicamino)chromones, the biological activity of 3-(N-cyclicamino)chromones has not been reported. In this study, cytotoxicity of 15 3-(N-cyclicamino)chromone deriva...

journal_title：Anticancer research

authors： Shi H,Nagai J,Sakatsume T,Bandow K,Okudaira N,Uesawa Y,Sakagami H,Tomomura M,Tomomura A,Takao K,Sugita Y

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:The purpose of the present study was to correlate the nuclear expression of p53 and p21 with response to paclitaxel and carboplatin, progression-free survival (PFS) as well as overall survival (OS), in patients with urothelial metastatic transitional-cell carcinoma (TCC). PATIENTS AND METHODS:Histological s...

journal_title：Anticancer research

authors： Flamm M,Brodowicz T,Haitel A,Susani M,Tomek S,Köstler W,Pycha A,Kratzik C,Marberger M,Zielinski CC

更新日期：2002-03-01 00:00:00

abstract：:Analysis of the overall patterns of gene expression at the polypeptide synthesis level has revealed two S-phase specific, proliferation sensitive nuclear proteins [cyclin (PCNA) and dividin (phosphoprotein)] whose rate of synthesis increases at the G1/S transition border of the cell cycle. All available evidence sugge...

journal_title：Anticancer research

authors： Celis JE,Madsen P,Nielsen S,Rasmussen HH

更新日期：1987-07-01 00:00:00

abstract：:Glycerophosphoinositols are metabolites formed by the sequential action of a phospholipase A2 specific for membrane phosphoinositides, and a lysolipase. Increased levels of these compounds characterize cell lines of different origin transformed by ras and other oncogenes. Thus, glycerophosphoinositols have been propos...

journal_title：Anticancer research

authors： Corda D,Falasca M

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Several attempts have been made to determine whether interphase fluorescence in situ hybridization (I-FISH) on bone marrow or peripheral blood specimens is a good alternative to conventional cytogenetics (CC) in calculating the residual proportion of Philadelphia (Ph) chromosome-positive cells during treatme...

journal_title：Anticancer research

authors： Douet-Guilbert N,Morel F,Le Charpentier T,Le Bris MJ,Herry A,Morice P,Bourquard P,Abgrall JF,Berthou C,De Braekeleer M

更新日期：2004-07-01 00:00:00

abstract：:CYFRA 21-1 was evaluated in 115 untreated patients with malignant pleural effusions (96 with primary lung cancer and 19 with non lung cancer) and 99 patients with benign pleural effusions. The levels of pleural fluid CYFRA 21-1 were from 1 to 385 times higher than those in serum, in all the examined patients. The mean...

journal_title：Anticancer research

authors： Toumbis M,Rasidakis A,Passalidou E,Kalomenidis J,Alchanatis M,Orphanidou D,Jordanoglou J

更新日期：1996-07-01 00:00:00

abstract：:Valproic acid (VPA) has been considered as a possible treatment agent for malignant gliomas. In order to characterise the possibilities of VPA, we investigated the effects on cell migration and proliferation. Human cell lines T98G, A172, 85HG66 and 86HG39 were treated with VPA or left untreated, afterwards Boyden cham...

journal_title：Anticancer research

authors： Knüpfer MM,Pulzer F,Schindler I,Hernaíz Driever P,Knüpfer H,Keller E

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Transient hypocalcaemia is a frequent complication after total knee arthroplasty (TKA). In this study, we investigated the factors associated with the development of hypocalcaemia after TKA in order to explore its clinical significance and treatment. PATIENTS AND METHODS:A retrospective analysis of the chan...

journal_title：Anticancer research

authors： Gai P,Sun H,Sui L,Wang G

更新日期：2016-03-01 00:00:00