Expression of cyclin (PCNA) and the phosphoprotein dividin are late obligatory events in the mitogenic response.

abstract：BACKGROUND/AIM:Adenoid cystic carcinoma (SGC) is a common type of salivary gland cancer (SGC). Surgery is the first treatment choice because chemoradiotherapy is usually not effective. Therefore, new treatment modalities are urgently needed. In this study, it was investigated whether the estrogen axis could be a treatm...

journal_title：Anticancer research

authors： Sumida T,Ishikawa A,Kamata YU,Nakano H,Yamada T,Mori Y

更新日期：2016-06-01 00:00:00

abstract：AIM:Combined cisplatin-topotecan therapy is standard care for advanced cervical cancer, however it is associated with haematotoxicity and nephrotoxicity. This trial was designed to assess the combination of carboplatin which is less nephrotoxic, and oral topotecan. PATIENTS AND METHODS:Patients with advanced/recurrent...

journal_title：Anticancer research

authors： Kurtz JE,Freyer G,Joly F,Gladieff L,Kaminski MC,Fabbro M,Floquet A,Hardy-Bessard AC,Raban N,Ray-Coquard I,Pujade-Lauraine E,GINECO Group, France.

更新日期：2012-03-01 00:00:00

abstract：:The presence of steroid receptors in breast cancer is usually considered as a good indicator for responsiveness to antiestrogen treatment. However, not all estrogen-receptor (ER) positive tumors respond to tamoxifen, probably owing to the natural heterogeneity of breast cancer, which after tamoxifen treatment can resu...

journal_title：Anticancer research

authors： Coradini D,Biffi A,Pirronello E,Di Fronzo G

更新日期：1995-03-01 00:00:00

abstract：:Inositol hexakisphosphate (InsP6) inhibits serine/threonine protein phosphatases type-1 (PP1), type-2A (PP2A) and type-3 (PP3) in a concentration-dependent manner. Since the activity of voltage-gated L-type Ca(2+)-channels is increased by inhibition of serine/threonine protein phosphatases, this may explain trhe incre...

journal_title：Anticancer research

authors： Barker CJ,Berggren PO

更新日期：1999-09-01 00:00:00

abstract：:Despite progress in chemotherapeutic agents, non-small cell lung cancers (NSCLC) still have a poor survival rate. Thus, development of new therapeutic strategies, specifically against cancer cells is still required. For this purpose, we treated the non-small cell lung cancer cell line NSCLC-N6 with the natural product...

journal_title：Anticancer research

authors： Jacquot C,Rousseau B,Carbonnelle D,Chinou I,Malleter M,Tomasoni C,Roussakis C

更新日期：2014-09-01 00:00:00

abstract：:MUC1 (DF3 antigen) is a member of a family of high molecular weight glycoproteins. Recent studies have demonstrated that MUC1 is expressed in tumors of various human organs and may function as an anti-adhesion molecule that inhibits cell-to-cell adhesion, inducing tumor metastasis. However, expression patterns of MUC1...

journal_title：Anticancer research

authors： Kijima H,Chino O,Oshiba G,Tanaka H,Kenmochi T,Kise Y,Shimada H,Abe Y,Tokunaga T,Yamazaki H,Nakamura M,Tanaka M,Makuuchi H,Ueyama Y

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Overexpression of heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 has recently been suggested to be a promising marker for early detection of lung cancer. The aim of this study was to determine the utility of its detection in bronchoscopic specimens. PATIENTS AND METHODS:Brushing and biopsy specimens ...

journal_title：Anticancer research

authors： Katsimpoula S,Patrinou-Georgoula M,Makrilia N,Dimakou K,Guialis A,Orfanidou D,Syrigos KN

更新日期：2009-04-01 00:00:00

abstract：:Norcantharidin[3], the demethylated product of cantharidin[1] has been used for the treatment of hepatoma, carcinomas of esophagus and gastric cardia, leukopenia and hepatitis. Since the enzyme xanthine oxidase is involved in the diseases mentioned above, and the reactive oxygen species produced by the enzyme induces ...

journal_title：Anticancer research

authors： Tsauer W,Lin JG,Lin PY,Hsu FL,Chiang HC

更新日期：1997-05-01 00:00:00

abstract：:The characteristics of Nepalese breast cancer in relation to reproductive factors have not been studied. One hundred and nine Nepalese breast cancer patients were compared with 108 Japanese breast cancer patients and the expression of estrogen (ER) and progesterone receptor (PgR) was evaluated immunohistochemically in...

journal_title：Anticancer research

authors： Singh Y,Sayami P,Sayami G,Nakagawa H,Koreeda T,Hatano T,Tsubura A

更新日期：2002-01-01 00:00:00

abstract：:This randomized study was designed to compare the efficacy and toxicity of MMV chemotherapy (mitomycin C(MMC), methotrexate (MTX) and vincristine(VCR)), MMVM (MMV+medroxyprogesterone acetate(MPA)) and MMVP (MMV+prednisolone(P)), and to evaluate potential additional effects of MPA or P to the chemotherapy in doxorubici...

journal_title：Anticancer research

authors： Tashiro H,Nomura Y

更新日期：1995-09-01 00:00:00

abstract：:The abilities of 14 phenothiazines, 8 benzo[a]phenothiazines and 12 benz[c]acridines to induce an antibacterial effect against Escherichia coli K12 were compared. Several phenothiazines, which showed antiplasmid activity, displayed the most potent antibacterial activity. All benz[c]acridine derivatives were moderately...

journal_title：Anticancer research

authors： Motohashi N,Sakagami H,Kurihara T,Ferenczy L,Csuri K,Molnar J

更新日期：1992-07-01 00:00:00

abstract：:Neurotrophins are a family of growth factors that are vital to the proper development of the central nervous system. Their effects on cells are governed by the expression and activation of the tyrosine kinase receptors TrkA, TrkB and TrkC. TrkB has been immensely implicated in mediating neuronal migration, development...

journal_title：Anticancer research

authors： Radin DP,Patel P

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Cervical cancer constitutes the second most common cancer in women. Estrogen promotes development of cervical cancer in cells infected with high risk human papillomaviruses (HPVs). We asked whether the phytochemical indole-3-carbinol (I3C) has anti-estrogenic activities in cervical cells with the goal of pre...

journal_title：Anticancer research

authors： Yuan F,Chen DZ,Liu K,Sepkovic DW,Bradlow HL,Auborn K

更新日期：1999-05-01 00:00:00

abstract：:We report a case with unexpected toxicity after low-dose docetaxel chemotherapy. The patient had a history of clinically latent HCV-positive hepatic cirrhosis when she presented with inoperable pulmonary adenocarcinoma. She was recruited in a protocol combining standard radiotherapy (RT) with docetaxel (30 mg/m2 week)...

journal_title：Anticancer research

authors： Koukourakis MI,Kapsoritakis A,Maltezos E,Potamiano S,Mouzas I,Kouroumalis H

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Prolonged exposure to asbestos, a potent carcinogen, has been the generally accepted factor responsible for the development of human mesotheliomas. Recent reports documenting the detection of SV40 DNA in human mesotheliomas suggest the possibility that this known tumor virus may be an additional factor invol...

journal_title：Anticancer research

authors： Arrington AS,Lednicky JA,Butel JS

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Despite improvements in chemotherapy and surgery in the treatment of osteosarcoma, satisfactory results are still difficult to achieve. New therapeutic modalities need to be developed for the improvement of these treatments. TRAIL (TNF-related apoptosis inducing ligand) is known as a selective apoptosis indu...

journal_title：Anticancer research

authors： Takeda S,Iwai A,Nakashima M,Fujikura D,Chiba S,Li HM,Uehara J,Kawaguchi S,Kaya M,Nagoya S,Wada T,Yuan J,Rayter S,Ashworth A,Reed JC,Yamashita T,Uede T,Miyazaki T

更新日期：2007-03-01 00:00:00

abstract：:We present a new approach towards the detection of the mRNAs in formalin-fixed, paraffin-embedded samples using a reverse transcriptase (RT)-polymerase chain reaction (PCR). The total RNAs were extracted from 10-micron-thick sections and were reverse-transcribed, then the RT-products were subjected to PCR amplificatio...

journal_title：Anticancer research

authors： Tachibana M,Shinagawa Y,Kawamata H,Omotehara F,Horiuchi H,Ohkura Y,Kubota K,Imai Y,Fujibayashi T,Fujimori T

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND/AIM:In order to develop an efficient drug-delivery system (DDS), a lipopeptide-loaded liposome that functions as a platform for the transpeptidase reaction mediated by sortase A (SrtA) was constructed and its stability, as well as cell-specific targeting were evaluated in the present study. MATERIALS AND ME...

journal_title：Anticancer research

authors： Tabata A,Ohkubo Y,Anyoji N,Hojo K,Tomoyasu T,Tatematsu Y,Ohkura K,Nagamune H

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND/AIM:The differentiation of the mouse breast epithelial cell line HC11 is known to require confluence as well as the addition of hydrocortisone, insulin and prolactin. MATERIALS AND METHODS:Since confluence, which triggers the engagement of the cell-to-cell adhesion molecule E-cadherin, induces a dramatic in...

journal_title：Anticancer research

authors： Niit M,Geletu M,Taha Z,Arulanandam R,Cass J,Hoskin V,Elliott B,Gunning P,Raptis L

更新日期：2019-06-01 00:00:00

abstract：:It is well known that the activation of innate immune cells, especially antigen-presenting cells such as macrophages and dendritic cells, can ameliorate or exacerbate various diseases, including cancer. Currently, the macrophages and dendritic cells are categorized into several groups by their cell surface and intrace...

journal_title：Anticancer research

authors： Kadowaki T,Shimada M,Inagawa H,Kohchi C,Hirashima M,Soma G

更新日期：2012-06-01 00:00:00

abstract：:Hexamethylmelamine (HMM) has previously been shown to be active against ovarian, breast and small cell lung cancer. However HMM dose not have aromatase-inhibitory activity. A newly developed HMM derivative, 2-N,N-dimethylamino-4, 6-bis (1-H-imidazol-1-yl)-1,3,5-triazine (SAE9), was found to have direct antitumor activ...

journal_title：Anticancer research

authors： Tanino H,Kubota T,Yamada Y,Koh JI,Takeuchi T,Kase S,Furukawa T,Takahashi M,Fukuda S,Ogose N

更新日期：1993-05-01 00:00:00

abstract：:Angiogenesis is essential for tumour growth. Mostly hypervasculariced renal cell carcinoma (RCC) usually express angiogenic factors, e.g. basic fibroblast factor (bFGF), vascular endothelial growth factor, and angiogenin (ag). This study was designed to evaluate the improvement of serological angiogenesis-factors, the...

journal_title：Anticancer research

authors： Wechsel HW,Bichler KH,Feil G,Loeser W,Lahme S,Petri E

更新日期：1999-03-01 00:00:00

abstract：:Thalidomide was recently suggested to be angiogenesis-inhibitor following the demonstration of its activity in a rabbit cornea micropocket model. The purpose of the present study was to test its efficacy in solid tumors in mice. B16-F10 melanoma and CT-26 colon carcinoma cells were injected subcutaneously, intravenous...

journal_title：Anticancer research

authors： Gutman M,Szold A,Ravid A,Lazauskas T,Merimsky O,Klausner JM

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND/AIM:An active metabolite of the anti-leukemia agent clofarabine (Cl-F-ara-A) is an intracellular triphosphate form, Cl-F-ara-ATP. Monitoring this active form could provide crucial information for optimizing treatment regimens based on Cl-F-ara-A. A simple, isocratic HPLC method was developed. MATERIALS AND ...

journal_title：Anticancer research

authors： Yamauchi T,Nishi R,Ueda T

更新日期：2011-09-01 00:00:00

abstract：:TNF alpha is known to exert multi-regulatory effects on normal and malignant cell functions by binding to the corresponding cell surface receptor. However, the existence of cross interaction between TNF alpha and EGF receptor has been proposed. In this study, we investigated the modulatory effect of TNF alpha on EGF r...

journal_title：Anticancer research

authors： Wang D,Yang EB,Cheng LY

更新日期：1996-09-01 00:00:00

abstract：:Several studies have reported that high F18-fluorodeoxyglucose (FDG) uptake is predictive of poor prognosis and aggressive features in patients with breast cancer. While these studies evaluated the prognostic value for cases with high FDG uptake, they did not elucidate the meaning of FDG negativity in primary breast c...

journal_title：Anticancer research

authors： Fujii T,Yajima R,Tsuboi M,Higuchi T,Obayashi S,Tokiniwa H,Nagaoka R,Takata D,Horiguchi J,Kuwano H

更新日期：2016-06-01 00:00:00

abstract：:Secreted pro-cathepsin B of HS-24 human lung-tumour cells, human alveolar macrophages and Wi-38 human lung-fibroblast cells was pre-purified by ion exchange chromatography and investigated by 2D gel electrophoresis. Four (Wi-38), six (HS-24) and ten (alveolar macrophages) polypeptides differing in charge, but with the...

journal_title：Anticancer research

authors： Werle B,Ebert W,Klein W,Spiess E

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Pemetrexed and erlotinib represent novel agents for the treatment of non-small cell lung cancer (NSCLC). The role of sequential treatment in NSCLC has not been elucidated yet. We compared the efficacy of second-line pemetrexed followed by third-line erlotinib (P-E) to treatment with the reverse sequence (E-P...

journal_title：Anticancer research

authors： Fiala O,Pesek M,Finek J,Benesova L,Bortlicek Z,Minarik M

更新日期：2013-08-01 00:00:00

abstract：:Metastatic pancreatic malignant melanoma is considered to be a highly aggressive neoplasm, and only few metastasectomies for lesions originating from the skin or the ocular region have been reported. We report a case of resection of pancreatic metastasis of malignant melanoma originating from the nasal cavity. An isol...

journal_title：Anticancer research

authors： Sugimoto M,Gotohda N,Kato Y,Takahashi S,Kinoshita T,Shibasaki H,Kojima M,Ochiai A,Zenda S,Akimoto T,Konishi M

更新日期：2013-02-01 00:00:00

abstract：:Chemosensivity testing in 11 retinoblastoma (RB) cell lines identified five tumors showing cross-resistance to plant alkaloids, alkylating agents, anthracycline antibiotics, and antimetabolites, suggestive of the multidrug-resistant (MDR) phenotype described in other tumors. Only two tumors had been clinically exposed...

journal_title：Anticancer research

authors： Chan HS,Canton MD,Gallie BL

更新日期：1989-03-01 00:00:00