Abstract:
:This randomized study was designed to compare the efficacy and toxicity of MMV chemotherapy (mitomycin C(MMC), methotrexate (MTX) and vincristine(VCR)), MMVM (MMV+medroxyprogesterone acetate(MPA)) and MMVP (MMV+prednisolone(P)), and to evaluate potential additional effects of MPA or P to the chemotherapy in doxorubicin (ADR)-refractory cancer patients. A total of 108 advanced breast cancer patients who had been resistant to ADR or who had relapsed after response were randomized to the three treatment arms: MMC 4mg/m2, MTX 35mg/m2 and VCR 0.7mg/m2, i.v., on days 1 and 8; repeated every 3 weeks. MPA 1,200 mg/day or P 10mg/day was given orally in the MMVM and MMVP arms, respectively. An interim analysis showed that the response to MMV was marginally significantly lower than the other groups; entry to the arm was thus interrupted. 102 patients were evaluable. Totally, response rates of 9.5%(2/21) in MMV, 37.5%(15/40) in MMVM and 29.2%(12/41) in MMVP were obtained. There was a significant difference in the response between the MMVM and MMV arms (p = 0.0206), and a marginal difference between MMVP and MMV (p = 0.0784). Although overall survivals in the 3 groups were equivalent, the time to progression of patients treated with MMVM and MMVP was shown to be significantly longer than MMV patients. Hematological adverse effects, especially thrombocytopenia, were significantly diminished by the addition of hormones, particularly MPA, to the chemotherapy, thus increasing total doses of chemotherapeutic agents. It was shown that in ADR-resistant cancers MMVM had an effect equivalent to that in ADR-sensitive breast cancers. The authors conclude that MMVM may be a candidate for a noncross resistant regimen for ADR-resistant cancers, as well as an effective 2nd line chemoendocrine treatment of advanced breast cancer.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Tashiro H,Nomura Ysubject
Has Abstractpub_date
1995-09-01 00:00:00pages
2229-37issue
5Beissn
0250-7005issn
1791-7530journal_volume
15pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND/AIM:To describe real clinical outcomes when using systemic therapy to treat non-small cell lung cancer (NSCLC) patients who have anaplastic lymphoma kinase (ALK) fusion gene mutation. PATIENTS AND METHODS:We performed a retrospective chart review from April 2008 to March 2019 sourced from 16 medical institu...
journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.14029
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:CYP3A4 is the most abundant xenobiotic-metabolizing cytochrome P450 isoform. We examined the structural features of the CYP3A4 molecule with regard to ligand access. MATERIALS AND METHODS:The deleted amino acid sequences of X-ray data sets of CYP3A4s were complemented by molecular modeling techniques. Molec...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
abstract::The centrifugal spreading of multicellular aggregates from a DMH induced colon adenocarcinoma cell line from rats was observed in vitro. Various concentrations of pentagastrin were added to the culture medium. Controls included medium alone or culture medium containing different concentrations of either NH4OH or NaOH ...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00
abstract:AIM:The suitability of Papanicolaou staining and of hematoxylin staining for DNA single-cell cytometry was investigated in comparison to Feulgen staining. MATERIALS AND METHODS:Ten normal cervical smears and ten cervical smears containing cells of a squamous cell carcinoma in situ were analyzed. The integrated optical...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Important strategies against cancer are based on the understanding of the mechanisms of tumor progression. To elucidate alterations regarding tumor progression, we have performed proteomic differential display analysis for the expression of intracellular proteins in the regressive murine fibrosarcoma cell clone QR-32 ...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract::We have developed a chemosensitivity assay of human tumors growing on collagen-sponge-gel-supported histoculture. This assay is thus termed the Histoculture Drug Response Assay (HDRA). In the HDRA, the end points of [3H]thymidine incorporation measured by histological autoradiography and tetrazolium dye reduction were...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::The radical modulation activity of hot water and NaOH extracts of the thorn apple of Crataegus Cuneata Sieb. et. Zucc. was investigated, using ESR spectroscopy. The radical intensity of sodium ascorbate was slightly reduced at lower concentrations of the extracts, but it was synergistically enhanced at higher concentr...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract::Dynamic liver RES scintigraphy with Nanocoll (99Tcm albumin colloid - 50 nm diameter) assessing RES-macrophage phagocytic function was performed in 40 control, 73 RES-stimulated non-tumour-bearing and 59 tumour-bearing Wistar/FU rats in vivo. Tumour-bearing rats were inoculated with 10(6) x 1.0 cells of a syngeneic ni...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:NSC697923, a ubiquitin-conjugating enzyme E2 (UBE2) inhibitor, was suggested as an agent to degrade hypoxia-inducible factor 1 alpha subunit (HIF1α), a key factor in radiation resistance. We attempted to clarify whether NSC697923 could overcome radiation resistance. MATERIALS AND METHODS:Radiation resistanc...
journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.11582
更新日期:2017-05-01 00:00:00
abstract::The authors report their experience in the radioimmunodetection of recurrent colorectal cancer in comparison with traditional examinations. 485 patients were studied after radical surgery for colorectal cancer: 168 (Group 1) were studied with a radioimmunoassisted follow-up plan including: Immunoscintigraphy (IS), ser...
journal_title:Anticancer research
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND/AIM:Soluble mesothelin-related peptide (SMRP) is regarded as a biomarker of malignant pleural mesothelioma (MPM). Herein, we compared the diagnostic performances of SMRP in matched pleural effusion (PE-SMRP) and serum (S-SMRP). MATERIALS AND METHODS:Diagnosis on pleural biopsies was performed for all patien...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND/AIM:Competing mortality risks complicate treatment of elderly melanoma patients potentially leading to conservative management, including no sentinel lymph node biopsy. As systemic immunotherapy offers justification for nodal evaluation, we examined treatment trends among elderly melanoma patients. PATIENTS...
journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.14266
更新日期:2020-05-01 00:00:00
abstract::Radiation therapy plays a critical role in women with advanced-stage cervical cancer worldwide, particularly in developing countries, and most of the time it may be the only available treatment. The efficacy of radiation largely depends on the radiosensitivity of the tumor. The high radiation dose associated with ther...
journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
更新日期:2014-09-01 00:00:00
abstract::Mutations in the p53 gene occur frequently in bladder cancers. Better prognostic factors are needed to help select appropriate treatment for patients with TCC stage T1. Paraffin-embedded tumors from 73 patients with TCC stage T1 were processed for two-parameter flow cytometry, measuring both p53 protein and DNA. There...
journal_title:Anticancer research
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::TRAIL, Tumor necrosis factor-related apoptosis-inducing ligand), a member of the TNF family, is known to be cytotoxic for a high proportion of tumor cell lines. However, successful application of TRAIL in tumor therapy may depend on finding other agents that can potentiate its antitumor effects. The present study show...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
abstract::The growth inhibitory effect of trimetrexate (TMQ) is maintained in MCF-7 breast cancer but is decreased in Hs 824.T human bone marrow cells by a priming- and non-toxic 5-fluorouracil (5-FU) dose. Incubation of MCF-7 breast cells with 10 microM TMQ alone or in combination with 10 M 5-FU (TMQ 2 h prior to 5-FU [TMQ/5-F...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::Radiomics, an emerging field in radiation therapy, is hypothesized to improve classification of tumour risk and prognosis. Despite encouraging results, there are issues of practicality and interpretation of radiomic data. This study investigates the emerging role of radiomics in tumour risk classification and prognosi...
journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:10.21873/anticanres.14350
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:As the incidence of lung cancer in the elderly is increasing worldwide, there exists a need to develop a clinically effective, less toxic therapy for this patient population. Although erlotinib has shown proven effectiveness against non-small cell lung cancer (NSCLC), few studies have prospectively investiga...
journal_title:Anticancer research
pub_type: 杂志文章,多中心研究
doi:
更新日期:2016-06-01 00:00:00
abstract::Calcitriol (1,25-dihydroxyvitamin D3), the active form of vitamin D, promotes growth inhibition and differentiation in prostate cancer (PCa) cells. To unravel the molecular pathways of calcitriol actions, cDNA microarray analysis was used to identify novel calcitriol target genes including two that play key roles in t...
journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
更新日期:2006-07-01 00:00:00
abstract:AIM:To evaluate the influence on relapse-free survival (RFS) and overall survival (OS) of a transitory protective stoma (TPS) at the time of complete cytoreductive surgery for advanced-stage ovarian cancer. PATIENTS AND METHODS:From our Institution, we retrospectively selected patients from 2006 to 2011 with ovarian c...
journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.12379
更新日期:2018-03-01 00:00:00
abstract::Several studies have reported that high F18-fluorodeoxyglucose (FDG) uptake is predictive of poor prognosis and aggressive features in patients with breast cancer. While these studies evaluated the prognostic value for cases with high FDG uptake, they did not elucidate the meaning of FDG negativity in primary breast c...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Adverse outcomes in breast cancer patients treated with recombinant human erythropoietin (rhEpo) have been linked to the expression of Epo-receptors (EpoR) in cancer cells, although limited data on the clinical significance of these observations are available. PATIENTS AND METHODS:Tissue samples from 107 pa...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
abstract::Evidence exists that estrogen metabolism has a role in the pathogenesis of recurrent respiratory papillomatosis (RRP). This disease has a papillomavirus etiology and is characterized by recurrent benign tumors with a significant propensity to become malignant. We have measured the systemic transformation of estrogen u...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Carcinoma of the ampulla of Vater is an infrequent tumor that can be diagnosed, early. PATIENTS AND METHODS:Twenty-four patients with histologically proven carcinoma of the ampulla of Vater were retrospectively studied and their data were analyzed. RESULTS:Most common presenting symptoms were jaundice (67%...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::A new cell line, CC3/CUHK3, was established from a squamous carcinoma of the uterine cervix from a Chinese patient. Light microscopy of the cell line revealed keratin and electron microscopy demonstrated tonofilaments and desmosomes, thereby confirming its epithelial nature. The population doubling time of CC3/CUHK3, ...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Antioxidants have the potential to protect normal tissues against radiation-induced damage, but must not protect tumor cells during radiotherapy. The major objectives were to determine whether a metalloporphyrin antioxidant affects prostate tumor response to radiation and identify possible mechanisms of inte...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
abstract:AIM:To evaluate the efficacy and toxicities of cisplatin and daily oral etoposide in patients with recurrent cervical cancer. PATIENTS AND METHODS:Treatment was initiated with oral etoposide 25 mg/day for 21 consecutive days, with intravenous cisplatin at 50 mg/m², on day 1, every 4 weeks, then the etoposide dose was ...
journal_title:Anticancer research
pub_type: 杂志文章,多中心研究
doi:
更新日期:2011-09-01 00:00:00
abstract::Throughout the world, breast cancer is among the major causes of cancer-related death and is the most common cancer found in women. The development of cancer molecular knowledge has surpassed the novel concept of cancer biology and unraveled principle targets for anticancer drug developments and treatment strategies. ...
journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:10.21873/anticanres.12502
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:A phase I/II study of docetaxel (DOC) and gemcitabine (GEM) combination for treatment-resistant ovarian cancer (OC) was conducted. MATERIALS AND METHODS:Eligible patients exhibited recurrent OC within 12 months after initial treatment, or after more than 2 chemotherapy regimens. Planned dose levels (DL) wer...
journal_title:Anticancer research
pub_type: 杂志文章,多中心研究
doi:
更新日期:2009-05-01 00:00:00
abstract::Three sublines have been derived from the parental line Mv1Lu by transfection with normal and mutated Ha-ras, and myc oncogenes, and subsequent cloning. All the oncogenes have increased the growth rate of the cell in vitro, increased their plating efficiency in monolayer and suspension, and reduced their serum depende...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00