Abstract：
AIM:To evaluate the efficacy and toxicities of cisplatin and daily oral etoposide in patients with recurrent cervical cancer. PATIENTS AND METHODS:Treatment was initiated with oral etoposide 25 mg/day for 21 consecutive days, with intravenous cisplatin at 50 mg/m², on day 1, every 4 weeks, then the etoposide dose was increased to 50 mg/day. RESULTS:Thirty patients were enrolled in this study. Twenty-seven (90.0%) patients had a history of prior treatment (cisplatin with concurrent chemoradiotherapy in 15, radiation therapy in 3, chemotherapy in 1, and both radiation therapy and chemotherapy in 9), and 22 (73.3%) patients had a treatment-free interval of less than 6 months. NCI-CTC grade 3/4 hematologic toxicities were leukopenia in 19 (63.3%), neutropenia in 17 (58.6%), anemia in 15 (50.0%) and thrombocytopenia in 6 (20.0%). Four patients developed febrile neutropenia. NCI-CTC grade 3 nonhematologic toxicities consisted of nausea/vomiting in 2 (6.7%), anorexia in 4 (13.3%) and fatigue in 2 (6.7%). The overall response rate was 16.7% including one complete response. The median progression-free survival period and overall survival period were 4.5 and 9.7 months, respectively. CONCLUSION:Combination chemotherapy consisting of oral etoposide and intravenous cisplatin is safe and effective for recurrent cervical cancer.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Watanabe Y,Hoshiai H,Nakanishi T,Kawamura N,Tanaka N,Isaka K,Kamiura S,Ohmichi M,Hatae M,Ochiai Ksubject
Has Abstractpub_date
2011-09-01 00:00:00pages
3063-7issue
9eissn
0250-7005issn
1791-7530pii
31/9/3063journal_volume
31pub_type
杂志文章,多中心研究abstract：:The reverse transcriptase polymerase chain reaction (RT-PCR) can be of clinical relevance in identifying malignant melanoma cells in blood or tissues of patients at risk for disseminated melanoma. The diagnostic value of this marker however, is still controversial. The objective of this study was to compare and quanti...
journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2000-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2012-05-01 00:00:00
abstract：:Intratumoral (cervix uterine tumors) distribution of platinum was studied in ten patients after IV administration of CDDP. Sequential tumoral measurement of platinum was carried out 4, 24, and 48 h after the IV infusion. Platinum concentration in the tumor samples ranged from 0 to 29,5 ng/mg tissue. For all patients, ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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pub_type： 杂志文章
doi：
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journal_title：Anticancer research
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journal_title：Anticancer research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：
更新日期：2015-10-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,评审
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journal_title：Anticancer research
pub_type： 杂志文章
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journal_title：Anticancer research
pub_type： 杂志文章,多中心研究
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更新日期：1999-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
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更新日期：2013-08-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2003-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
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journal_title：Anticancer research
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更新日期：1999-03-01 00:00:00
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pub_type： 杂志文章
doi：
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