Augmented pro-apoptotic effects of TRAIL and proteasome inhibitor in human promonocytic leukemic U937 cells.

abstract：:Methods for improving the estrogen receptor (ER) and progestin receptor (PgR) assay were studied. Using DCC procedure as the basis, the extraction and incubation of ER and PgR is more efficiently achieved by phosphate buffer as compared with water, tris and veronal buffers. The multiple extractions of hormone receptor...

journal_title：Anticancer research

authors： Chen YM,Rice RG,Vaughn CB

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Deregulated RAS/RAF/MAPK and PI3K/AKT/mTOR signaling pathways are found in hepatocellular carcinoma (HCC). This study aimed to test the inhibitory effects of PI-103 (a small molecule inhibitor of PI3K and mTOR) and sorafenib as single agents and in combination on HCC tumorigenesis in an in vivo xenograft mod...

journal_title：Anticancer research

authors： Gedaly R,Angulo P,Chen C,Creasy KT,Spear BT,Hundley J,Daily MF,Shah M,Evers BM

更新日期：2012-07-01 00:00:00

abstract：:We examined the optimal timing for the enhancement of antitumor effects of CDDP analogues, cis- diammine-1,1- cyclobutane dicarboxylate platinum (II); CBDCA combined with hyperthermia against the CD-1 mice bearing Ehrlich ascites tumor (EAT) cells in vivo. The prolonged tumor doubling time was observed when two modali...

journal_title：Anticancer research

authors： Mizuuchi H,Yoshiga K,Sakurai K,Tsumura M,Takada K

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Venous thromboembolism (VTE) is associated with cancer. Cancer patient with thromboembolism have poorer prognosis. This study assessed the risk and mortality in pancreatic cancer patients who develop VTE. PATIENTS AND METHODS:A retrospective chart review was performed of 201 patients with pancreatic cancer....

journal_title：Anticancer research

authors： Shaib W,Deng Y,Zilterman D,Lundberg B,Saif MW

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:A double blind placebo RCT of adjuvant treatment of the matrix metalloproteinase inhibitor, Marimastat, in patients with unresectable colorectal liver metastases showed no significant effect on survival. There was a statistically significant survival advantage for the marimastat-treated patients with musculo...

journal_title：Anticancer research

authors： King J,Zhao J,Clingan P,Morris D

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Several studies have supported the hypothesis that the concept of immuno-surveillance would not be effective in cancer patients. One reason for suppression of antitumor immunity may be attributed to immune impairment of T-lymphocytes, which extends beyond the tumor-microenvironment and might effect the perip...

journal_title：Anticancer research

authors： Gruber IV,El Yousfi S,Dürr-Störzer S,Wallwiener D,Solomayer EF,Fehm T

更新日期：2008-03-01 00:00:00

abstract：:High-dose methotrexate (MTX) cytotoxicity is decreased in MCF-7 breast cancer cells when the chemoendocrine agent tamoxifen (TAM) is given to cells 24 hours prior to MTX (early TAM). However, when breast cancer cells are exposed to TAM 24 hours after MTX (delayed TAM), MTX cytotoxicity is enhanced by TAM. The growth o...

journal_title：Anticancer research

authors： Bowen D,Southerland WM,Hawkins M Jr,Johnson DH

更新日期：2000-05-01 00:00:00

abstract：:Fine needle aspiration (FNA) cytology, being the mainstay to diagnose thyroid nodules, does not provide definitive results in a subset of patients. The use of molecular markers testing has been described as a useful aid in differentiation of thyroid nodules that present with an indeterminate cytodiagnosis. Molecular t...

journal_title：Anticancer research

authors： Bhatia P,Deniwar A,Friedlander P,Aslam R,Kandil E

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:We conducted a phase II study of topotecan (Tp) with cisplatin (CDDP) in previously untreated Japanese patients with extensive-disease small cell lung cancer (ED-SCLC). PATIENTS AND METHODS:In stage 1, a total of 30 patients were allocated to Tp 0.65 mg/m(2) with CDDP 60 mg/m(2) day 1 or Tp 1.00 mg/m(2) wit...

journal_title：Anticancer research

authors： Hosomi Y,Shibuya M,Niho S,Ichinose Y,Kiura K,Sakai H,Takeda K,Kudo S,Eguchi K,Matsui K,Masuda N,Ando M,Watanabe K

更新日期：2011-10-01 00:00:00

abstract：:Iron salts supplemented in a basal ratio, were fed to young Sprague-Dawley male rats for prolonged periods and the frequency of colonic adenocarcinomas induced by repeated s.c. injection of 1,2-dimethylhydrazine (DMH) at unit base doses of 9.0 mg/kg, ascertained and compared with the respective controls. In a series e...

journal_title：Anticancer research

authors： Gershbein LL,Rezai VK,Amir-Mokri E,Rao KC

更新日期：1993-11-01 00:00:00

abstract：:A 70-year-old man with a growing liver tumor had undergone subtotal gastrectomy with pancreaticoduodenectomy for gastric cancer (T4b P0 H0 N1, Stage IIIB) 30 months before admission to our hospital. Enhanced computed tomography revealed two hypervascular nodules in segments 4 and 8. After histological diagnosis of sma...

journal_title：Anticancer research

authors： Kinoshita K,Beppu T,Miyata T,Kuramoto K,Yoshida Y,Umesaki N,Kitano Y,Nakagawa S,Okabe H,Nitta H,Imai K,Hayashi H,Yamashita YI,Komori H,Horino K,Misumi A,Baba H

更新日期：2018-03-01 00:00:00

abstract：:The in vitro antioxidative activity of benzylideneascorbate (SBA) and the in vivo effect on adriamycin (ADR)-induced cardiotoxicity in a mouse model were investigated. The radical-scavenging activity of SBA was assayed in terms of reduction of chemiluminescence induced by O2-, generated in xanthine/xanthine oxidase an...

journal_title：Anticancer research

authors： Kojima S,Iizuka H,Yamaguchi H,Tanuma S,Kochi M,Ueno Y

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:The aim of this retrospective study was to evaluate the clinical relevance of serum p53 antibody (S-p53Ab) as a biomarker and to investigate whether its diagnostic value could be improved when combined with other biomarkers of gastric cancer (GC). PATIENTS AND METHODS:Serum samples were obtained preoperativ...

journal_title：Anticancer research

authors： Kunizaki M,Fukuda A,Wakata K,Tominaga T,Nonaka T,Miyazaki T,Matsumoto K,Sumida Y,Hidaka S,Yasutake T,Sawai T,Hamamoto R,Nanashima A,Nagayasu T

更新日期：2017-04-01 00:00:00

abstract：:Between January 1996 and June 2000, 192 men with prostate cancer underwent radical retropubic prostatectomy (RP) and bilateral pelvic node dissection in 26 centers participating in the Italian randomized prospective TAP study. The reviewing pathologist evaluated 145 RP specimens. Seventy-five cases had not been treate...

journal_title：Anticancer research

authors： Mazzucchelli R,Montironi R,Prezioso D,Bono AV,Ferrari P,Manganelli A,Morelli P,De Vito ML,Santinelli A,Diamanti L,Lotti T,Polito M,Takeda Italian TAP Study Group.

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Most cancer cells exhibit increased anaerobic glycolysis and use this metabolic pathway for the generation of ATP as a main source of energy. This impaired metabolism of glucose, leading to the secretion of lactic acid even in the presence of oxygen, is named the Warburg effect. Because cancer cells are part...

journal_title：Anticancer research

authors： Zhang X,Varin E,Briand M,Allouche S,Heutte N,Schwartz L,Poulain L,Icard P

更新日期：2009-04-01 00:00:00

abstract：:Cytogenetic and DNA flow cytometric analysis was carried out on four SV40T-transfected human buccal epithelial cells lines. One of these was immortalized and showed a nontumorigenic phenotype when tested in athymic nude mice. DNA flow cytometric ploidy values correlated well with cytogenetic ploidy values as calculate...

journal_title：Anticancer research

authors： Kulkarni Schmidt-Kastner PS,Heiden T,Tribukait B,Grafström RC

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors are uncommon intra-abdominal tumors. In fewer than 5% of cases, they originate primarily from the mesentery, omentum or peritoneum and these extra-gastrointestinal stromal tumors tend to have characteristics similar to gastrointestinal stromal. CASE REPORT:We report a case of...

journal_title：Anticancer research

authors： Rediti M,Pellegrini E,Molinara E,Cerullo C,Fonte C,Lunghi A,Iori A,Neri B

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND/AIM:Due to their unique composition of health-promoting compounds, the consumption of hazelnuts may contribute to the prevention of colon cancer. MATERIALS AND METHODS:Since hazelnuts are often consumed roasted, the impact of different roasting conditions (RC1=140.6°C/25 min, RC2=155.1°C/20 min and RC3=180....

journal_title：Anticancer research

authors： Glei M,Fischer S,Lamberty J,Ludwig D,Lorkowski S,Schlörmann W

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIM:The mechanism responsible for B-cell translocation gene 1 (BTG1) down-regulation in breast carcinoma remains unknown. We examined the BTG1 expression status in breast carcinoma cells and investigated the mechanism underlying the observed alterations. MATERIALS AND METHODS:Four breast carcinoma cell line...

journal_title：Anticancer research

authors： Woo HY,DO SI,Kim SH,Song SY,Kim HS

更新日期：2019-10-01 00:00:00

abstract：AIM:To investigate the relationship between erythrocyte sedimentation rate (ESR) and postoperative survival of patients with colorectal cancer (CRC). MATERIALS AND METHODS:Relationships between clinical characteristics and overall survival (OS) of patients with CRC were investigated using multivariate analysis. Receiv...

journal_title：Anticancer research

authors： Shibuya N,Ishizuka M,Takagi K,Iwasaki Y,Hachiya H,Aoki T,Kubota K

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Postoperative pancreatic fistula (POPF) remains a major complication after pancreaticoduodenectomy (PD), and the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) after PD is poor. PATIENTS AND METHODS:A multi-institutional retrospective study was performed in 174 patients who underwent PD ...

journal_title：Anticancer research

authors： Yamashita Y,Yoshizumi T,Fukuzawa K,Nishizaki T,Tsujita E,Kajiyama K,Soejima Y,Yamagata M,Yamamoto K,Adachi E,Sugimachi K,Ikeda Y,Uchiyama H,Maeda T,Itoh S,Harimoto N,Ikegami T,Maehara Y

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:NSC697923, a ubiquitin-conjugating enzyme E2 (UBE2) inhibitor, was suggested as an agent to degrade hypoxia-inducible factor 1 alpha subunit (HIF1α), a key factor in radiation resistance. We attempted to clarify whether NSC697923 could overcome radiation resistance. MATERIALS AND METHODS:Radiation resistanc...

journal_title：Anticancer research

authors： Gombodorj N,Yokobori T,Yoshiyama S,Kawabata-Iwakawa R,Rokudai S,Horikoshi I,Nishiyama M,Nakano T

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND/AIM:Insulin-like growth factor II mRNA-binding protein 3 (IMP3) plays an important role in the adhesion, invasion, and metastasis of tumor cells. Although emerging evidence suggests that IMP3 promotes tumor progression in several malignancies, the expression of IMP3 and its prognostic implication in adenocar...

journal_title：Anticancer research

authors： Kim HG,Park MS,Sung JY,Kim YW,Kim HS,Na K

更新日期：2019-09-01 00:00:00

abstract：AIM:To elucidate the behavior of 1 phosphatidylinositol 4,5 bisphosphate (PIP2) 5 phosphatase (PIP2 5-Pase, EC 3.1.3.36) and 1 phosphatidylinositol 4 phosphate (PIP) 4-phosphatase (PIP 4-Pase) in cancer cells, the steady state activities of PIP2 5-Pase and PIP 4-Pase were determined in the particulate fractions of rat ...

journal_title：Anticancer research

authors： Yang H,Shen F,Weber G

更新日期：1999-11-01 00:00:00

abstract：:The etiologic variables involved in the increased incidence of colorectal carcinoma in patients with chronic ulcerative colitis have not been defined. Sulfasalazine is the most commonly used medication in the treatment of ulcerative colitis. It is not known whether the pharmacologic treatment of ulcerative colitis alt...

journal_title：Anticancer research

authors： Andrianopoulos GD,Nelson RL,Barch DH,Nyhus LM

更新日期：1989-11-01 00:00:00

abstract：:This study is a sequel in our continuing efforts to improve the colony forming efficiency of the Human Tumor Colony Assay. We have previously reported that the use of culture media supplemented with rat red blood cells and a low oxygen environment resulted in notable improvements in the clonal growth of three differen...

journal_title：Anticancer research

authors： Katoh A,Charoensiri S,Tchirkow G

更新日期：1987-05-01 00:00:00

abstract：:Glutathione (GSH) concentration is high in most tumour cells and this may be an important factor in resistance to chemotherapy. Previous in-vitro and animal experiments have shown a differential response of tumour versus normal cells to various cysteine delivery systems. More specifically, an in-vitro assay showed tha...

journal_title：Anticancer research

authors： Kennedy RS,Konok GP,Bounous G,Baruchel S,Lee TD

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:A nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a lymphoproliferative neoplasm with a fair prognosis, but the possibility of a malignant transformation into a diffuse large B-cell lymphoma (DLBCL) is high. DLBCL progresses aggressively. Introduction of rituximab into therapy had led to improve...

journal_title：Anticancer research

authors： Gutsch J,Werthmann PG,Rosenwald A,Kienle GS

更新日期：2018-09-01 00:00:00

abstract：:The anticancer effects of retinoids have been recognized both in vivo and in vitro; however, little is known about their mechanism of action. Our study evaluated the effects of retinoic acid on the invasiveness of four human melanoma cell lines in vitro and showed a time-dependent inhibition of the ability of these ce...

journal_title：Anticancer research

authors： Wood WR,Seftor EA,Lotan D,Nakajima M,Misiorowski RL,Seftor RE,Lotan R,Hendrix MJ

更新日期：1990-03-01 00:00:00

abstract：:MOv18, a non-internalizing monoclonal antibody (MAb) with restricted tumor specificity, was conjugated to ricin toxin (RT). According to their ability to bind to galactose residues of Sepharose 6B, the immunoconjugates were fractionated into Bound and Unbound MOv18-RT. The two conjugates could be distinguished by SDS-...

journal_title：Anticancer research

authors： Cogliati T,Brusa P,Canevari S,Caldera M,Mezzanzanica D,Dosio F,Cattel L,Colnaghi MI

更新日期：1991-01-01 00:00:00