Abstract：
BACKGROUND:We conducted a phase II study of topotecan (Tp) with cisplatin (CDDP) in previously untreated Japanese patients with extensive-disease small cell lung cancer (ED-SCLC). PATIENTS AND METHODS:In stage 1, a total of 30 patients were allocated to Tp 0.65 mg/m(2) with CDDP 60 mg/m(2) day 1 or Tp 1.00 mg/m(2) with CDDP day 5 following prophylactic granulocyte colony stimulating factor (G-CSF) from day 6. In stage 2, the selective combination in 29 patients was evaluated for response rate, toxicity and overall survival. RESULTS:In stage 1, Tp 1.00 mg/m(2) with CDDP day 5 was selected this schedule had a better hematological profile. In stage 2, the response rate was 83%, and grade 3/4 adverse events were hematological-toxicities. The median survival time was 17.5 months and the 1 year survival rate was 79%. CONCLUSION:Combination of Tp and CDDP on day 5 with G-CSF support is safe and effective for previously untreated ED-SCLC Japanese patients.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Hosomi Y,Shibuya M,Niho S,Ichinose Y,Kiura K,Sakai H,Takeda K,Kudo S,Eguchi K,Matsui K,Masuda N,Ando M,Watanabe Ksubject
Has Abstractpub_date
2011-10-01 00:00:00pages
3449-56issue
10eissn
0250-7005issn
1791-7530pii
31/10/3449journal_volume
31pub_type
杂志文章abstract：BACKGROUND:Elucidation of the biological features of triple negative breast cancer (TNBC) is important for deciding treatment strategies. The expression of a number of biomarkers in TNBC was analyzed to elucidate those features. PATIENTS AND METHODS:The subjects were 134 TNBC patients. Immunohistochemical staining was...
journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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doi：
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doi：
更新日期：1986-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
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doi：
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doi：
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doi：
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journal_title：Anticancer research
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doi：
更新日期：2014-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2008-05-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：1998-03-01 00:00:00
