Abstract：
BACKGROUND/AIM:The hormonally-active form of vitamin D, 1,25(OH)2D3, demonstrated activity against oral squamous cell carcinoma (OSCC). Cytochrome P450scc (CYP11A1)-derived vitamin D hydroxyderivatives, such as 20(OH)D3 and 1,20(OH)2D3, have overlapping beneficial effects with 1,25(OH)2D3 without causing hypercalcemia. This study sought to determine (i) whether 20(OH)D3 and 1,20(OH)2D3 exhibit antitumor effects against OSCC comparable to those of 1,25(OH)2D3 and (ii) whether these effects may stem from down-regulation of sonic hedgehog (SHH) or WNT/β-catenin signaling pathways. MATERIALS AND METHODS:Effects on CAL-27 cells were assessed by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt and spheroid assays. Signaling pathways were assessed by immunofluorescence and western blotting. RESULTS:20(OH)D3 and 1,20(OH)2D3 inhibited the growth of CAL-27 and demonstrated inhibition of WNT/β-catenin and the SHH signaling as evidenced by down-regulation of nuclear translocation of glioma-associated oncogene 1(GLI1) and β-catenin. CONCLUSION:Noncalcemic vitamin D hydroxyderivatives demonstrated antitumor activities against OSCC comparable to those of 1,25(OH)2D3 Their activities against SHH and the WNT/β-catenin pathways provide insight for a possible target for OSCC treatment.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Oak ASW,Bocheva G,Kim TK,Brożyna AA,Janjetovic Z,Athar M,Tuckey RC,Slominski ATdoi
10.21873/anticanres.14216subject
Has Abstractpub_date
2020-05-01 00:00:00pages
2467-2474issue
5eissn
0250-7005issn
1791-7530pii
40/5/2467journal_volume
40pub_type
杂志文章abstract：BACKGROUND:Angiogenesis is involved in the development of cancer, promoting tumor growth, invasiveness and metastasis. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor. The present case control study was carried out, to determine whether there is an association between the VEGF -2578C > A polymor...
journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2007-07-01 00:00:00
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journal_title：Anticancer research
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更新日期：2011-10-01 00:00:00
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doi：
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doi：
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journal_title：Anticancer research
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doi：
更新日期：1991-07-01 00:00:00
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doi：
更新日期：2012-08-01 00:00:00
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doi：
更新日期：2007-11-01 00:00:00
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更新日期：1996-09-01 00:00:00
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更新日期：2009-05-01 00:00:00
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更新日期：2008-07-01 00:00:00
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更新日期：2012-01-01 00:00:00
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更新日期：1988-05-01 00:00:00
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更新日期：2013-09-01 00:00:00
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doi：
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