Immunohistochemical expression patterns of neural and neuroendocrine markers, the neural growth factor receptors and the beta-tubulin II and IV isotypes in human thymus.

abstract：BACKGROUND:We hypothesize that dendritic cells (DCs) can process antigens from autologous melanoma apoptotic bodies (MABs) and induce effector T cells in melanoma patients. MATERIALS AND METHODS:Peripheral blood mononuclear cells were obtained from three stage IV melanoma patients and adherent cells were cultured in c...

journal_title：Anticancer research

authors： Chang JW,Peng M,Vaquerano JE,Zhou YM,Clinton RA,Hyun WC,Giedlin MA,Leong SP

更新日期：2000-05-01 00:00:00

abstract：:Between 70 and 75% of ovarian carcinomas are not discovered until they have reached an advanced stage III or later. Efforts should therefore be concentrated on earlier diagnosis. Ovarian cancer is not an entirely silent disease. Today, it is known that there are key symptoms which, depending on their frequency and int...

journal_title：Anticancer research

authors： Argento M,Hoffman P,Gauchez AS

更新日期：2008-09-01 00:00:00

abstract：:MDL 103,323, an enclomiphene analog, was tested for binding to the estrogen receptor, inhibition of human tumor xenografts and prevention of carcinogen-induced mammary tumors. MDL 103,323 had 5-6 fold greater affinity for the human estrogen receptor than did either tamoxifen or enclomiphene. Consistent with enhanced b...

journal_title：Anticancer research

authors： Bitonti AJ,Baumann RJ,Bush TL,Cashman EA,Wright CL,Prakash NJ

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate whether human papilloma virus (HPV) testing at LLETZ for CIN can be useful to identify patients with high risk of recurrent disease. MATERIALS AND METHODS:In 62 women treated with LLETZ for CIN the status of the resection margins was recorded and related to the HPV stat...

journal_title：Anticancer research

authors： Negri G,Gampenrieder J,Vigl EE,Haitel A,Menia E,Mian C

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The antitumor effect exerted by tumor necrosis factor (TNF) is characteristic in that it causes central necrosis of the tumor mass. Viable tumor cells surrounding the tumor mass remain, however, even after most of the mass is necrotized, and these cells gradually regrow and form tumors. To overcome this, we ...

journal_title：Anticancer research

authors： Inagawa H,Nishizawa T,Honda T,Nakamoto T,Takagi K,Soma G

更新日期：1998-09-01 00:00:00

abstract：:Approximately 85% of patients with advanced ovarian cancer will experience recurrence of the disease. In 311 patients CA125 serum levels were determined at follow up investigation in our department. A sensitivity of 92% and specificity of 89% were calculated. Reflecting the further course of disease, specificity could...

journal_title：Anticancer research

authors： Meier W,Baumgartner L,Stieber P,Hasholzner U,Fateh-Moghadam A

更新日期：1997-07-01 00:00:00

abstract：:One hundred and eighty-seven patients with a transitional cell bladder cancer were followed by retrospectively for a mean of 9.5 years. Clinical stage (p less than 0.0001), histological grade (p less than 0.0001), papillary (p less than 0.0001), SPF (p less than 0.0001), M/V index (p less than 0.0001), MAI (p less tha...

journal_title：Anticancer research

authors： Lipponen PK,Eskelinen MJ,Kiviranta J,Nordling S

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND/AIM:Vimentin3 (Vim3) was recently described as a tumour marker for the direct discrimination between benign and malignant kidney tumours. Here, we examined its expression in prostate cancer (PCa) cell lines and the regulation of its expression by endothelin receptors. MATERIALS AND METHODS:Prostate cancer c...

journal_title：Anticancer research

authors： KÖditz B,Stog A,GÖbel H,Heidegger I,Fries J,Heidenreich A,VON Brandenstein M

更新日期：2021-01-01 00:00:00

abstract：:Mutations in the p53 gene stimulate cell division. In our study we assessed the prognostic value of mutant p53 overexpression in cervical cancer stage FIGO III detected by immunohistochemistry. In 43 tissue specimens were detected p53 overexpression in 20 cases. Mean survival time was 36.4 (SE +/- 7.66) months in the ...

journal_title：Anticancer research

authors： Gitsch G,Kainz C,Joura E,Breitenecker G

更新日期：1992-11-01 00:00:00

abstract：:Metals and metal compounds have been used in medicine for several thousands of years. In this review we summarized the anti-cancer activities of the ten most active metals: arsenic, antimony, bismuth, gold, vanadium, iron, rhodium, titanium, gallium and platinum. The first reviewed metal, arsenic, presents the anomaly...

journal_title：Anticancer research

authors： Desoize B

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/AIM:Cisplatin nephrotoxicity includes early activation of the pro-apoptotic p66Shc and disorganization of the actin cytoskeleton, integrity which is regulated by heat-shock protein-27 (Hsp27). Here we determined the potential role of p66Shc in abrogating the Hsp27 function. MATERIALS AND METHODS:Effects of ...

journal_title：Anticancer research

authors： Arany I,Clark JS,Reed DK,Ember I,Juncos LA

更新日期：2012-11-01 00:00:00

abstract：:The PTEN gene is a tumor-suppressor gene that is inactivated in several types of human tumors. The loss of PTEN expression has been supported as a prognostic marker. Using immunohistochemical analysis, we retrospectively analyzed PTEN expression in specimens from 53 patients with completely resected stage I non-small ...

journal_title：Anticancer research

authors： Olaussen KA,Soria JC,Morat L,Martin A,Sabatier L,Morere JF,Khayat D,Spano JP

更新日期：2003-11-01 00:00:00

abstract：:Seventy five patients suffering from metastatic breast cancer previously unexposed to chemotherapy were treated with Cyclophosphamide, Methotrexate and 5-fluorouracil (CMF) upon diagnosis of their first relapse. Dose Level I (85% or more of the planned dose) was given to 14 patients (19%); Dose Level II (66% to 84% of...

journal_title：Anticancer research

authors： Brufman G,Biran S

更新日期：1986-07-01 00:00:00

abstract：:Cisplatin is the most active anticancer agent for lung cancer. It has been reported that intracellular accumulation of cisplatin is important in determining resistance to cisplatin, which may be modulated by Na+, K(+)-ATPase activity. On the other hand, it is well-known that sorbitol, a metabolite of glucose mediated ...

journal_title：Anticancer research

authors： Bando T,Fujimura M,Kasahara K,Shibata K,Shirasaki H,Heki U,Iwasa K,Ueda A,Tomikawa S,Matsuda T

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the clinical feasibility and surgical outcomes of robotic-assisted transperitoneal infrarenal para-aortic lymphadenectomy (TIPAL) in patients with gynecological malignancies. PATIENTS AND METHODS:The perioperative outcomes in 90 patients with gynecological malignancies who underwent laparos...

journal_title：Anticancer research

authors： Lee HJ,Lee YH,Chong GO,Hong DG,Lee YS

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Although oncological results for resection of colon cancer with inferior mesenteric artery (IMA) ligation at its origin (high tie) or immediately below the left colic artery (low tie) are similar, injury of the superior hypogastric plexus may be caused when the IMA is tied at its origin, thus impairing defec...

journal_title：Anticancer research

authors： Fiori E,Crocetti D,Lamazza A,DE Felice F,Scotti GB,Sterpetti AV,Mingoli A,Sapienza P,DE Toma G

更新日期：2020-05-01 00:00:00

abstract：AIM:To identify conditions that induce an increase in the sensitivity of highly Halaven (HAL)-resistant cancer cells compared to sensitive cells. MATERIALS AND METHODS:We observed that drug-resistant KBV20C cells are highly resistant to HAL compared to other antimitotic drugs. The concentration required to treat KBV20...

journal_title：Anticancer research

authors： Cheon JH,Lee BM,Kim HS,Yoon S

更新日期：2016-11-01 00:00:00

abstract：AIM:The aim of the present study was to detect the relative expressions of p53, p21(Waf1/Cip1), p27(Kip1) Bcl-2 and cleaved caspase-3 in cervical lesion samples from Brazilian women by immunohistochemistry. MATERIALS AND METHODS:A total of 230 cervical biopsies in paraffin-embedded blocks were studied: 43 were invasiv...

journal_title：Anticancer research

authors： Dobo C,Oshima CT,De Oliveira Lima F,Gomes TS,Stávale JN,Arias V,Ribeiro DA,Focchi GR

更新日期：2014-06-01 00:00:00

abstract：AIM:The present study aimed to examine the survival benefit of adjuvant chemotherapy for the patients with stage IB gastric cancer according to the second English edition of the Japanese Classification of Gastric Carcinoma (2nd JCGC). PATIENTS AND METHODS:In total, 201 consecutive patients who underwent curative surge...

journal_title：Anticancer research

authors： Toyokawa T,Ohira M,Sakurai K,Kubo N,Tanaka H,Muguruma K,Hirakawa K

更新日期：2015-07-01 00:00:00

abstract：:Measurement of CA125 is well established in the diagnosis and follow-up of ovarian cancer. CA125 determination is usually performed with the monoclonal antibodies OC125 and M11. For the IMMULITE OM-MA chemoluminsence assay (DPC Biermann, Bad Nauheim, Germany) the monoclonal antibody OV185 is used. We analysed CA125 se...

journal_title：Anticancer research

authors： Gebauer G,Rieger M,Jäger W,Lang N

更新日期：1999-07-01 00:00:00

abstract：:A 67-year-old man presented with leg edema. Laboratory data showed elevated blood glucose and carbohydrate antigen (CA) 19-9 levels, and anemia. Further imaging studies revealed a relatively clear-margined tumor totally occupying the main pancreatic duct (MPD) from the head to the tail of the pancreas (maximum diamete...

journal_title：Anticancer research

authors： Hioki M,Nakagohri T,Ikumoto T,Gotohda N,Takahashi S,Konishi M,Kojima M,Kinoshita T

更新日期：2010-11-01 00:00:00

abstract：:Biotransformation of irinotecan (CPT-11) into its pharmacologic active metabolite SN-38 was investigated in patients treated for advanced colorectal cancer. A dose of 180 mg/m(2) CPT-11 was administered to 6 patients by 60 min hepatic intra-arterial infusion (HAI) via a surgically implanted Port-a-Cath® system. Blood ...

journal_title：Anticancer research

authors： Czejka M,Kiss A,Koessner C,Terkola R,Ettlinger D,Schueller J

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND/AIM:The aim of the present study was to determine the efficacy of trabectedin combined with FOLFIRI (irinotecan, leucovorin and 5-fluorouracil) on a colorectal cancer (CRC) patient-derived orthotopic xenograft (iPDOX) mouse model. MATERIALS AND METHODS:A CRC tumor from a patient previously established in nu...

journal_title：Anticancer research

authors： Zhu G,Zhao M,Han Q,Tan Y,Sun YU,Bouvet M,Clary B,Singh SR,Ye J,Hoffman RM

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Regardless of current multimodal treatment strategies, the prognosis of patients harboring glioblastoma multiforme (GBM) is still dismal. The introduction of concomitant radiochemotherapy and adjuvant cyclic temozolomide has significantly improved the overall survival, compared to postoperative radiotherapy-...

journal_title：Anticancer research

authors： Kerschbaumer J,Freyschlag CF,Bauer R,Obwegeser AA,Schubert GA,Thomé C,Seiz M

更新日期：2012-12-01 00:00:00

abstract：:The use of gene-modified dendritic cells (DC) is a powerful tool to enhance antitumor immune responses stimulated by these cells in cancer immunotherapy. Cationized gelatin is preferably incorporated via phagocytosis and is gradually degraded by proteolysis while buffering lysosomal activity. This may be appropriate f...

journal_title：Anticancer research

authors： Inada S,Fujiwara H,Atsuji K,Takashima K,Araki Y,Kubota T,Tabata Y,Yamagishi H

更新日期：2006-05-01 00:00:00

abstract：AIM:To determine depression in patients with choroidal melanoma (CM) treated with proton beam radiotherapy. PATIENTS AND METHODS:This was a cross-sectional study including 50 patients with CM (50% males, mean age=49.88±6.34 years) and 46 age- and sex-matched healthy controls (52% males, mean age=48.60±8.05 years). Par...

journal_title：Anticancer research

authors： Moschos MM,Moustafa GA,Lavaris A,Damaskos C,Laios K,Karathanou E,Ladas DS,Asproudis I,Garmpis N,Kalogeropoulos C

更新日期：2018-05-01 00:00:00

abstract：:Immunoreactivity of monoclonal anti-cytokeratin KL1, PKK1, K8.12 and anti-actin antibodies in 101 cases of diseased human breast lesions showed irregular keratin distribution in luminal cells of terminal ductal-lobular unit and basal layer cells of the interlobular and main duct. Actin staining was confined to myoepit...

journal_title：Anticancer research

authors： Wada T,Yasutomi M,Yamada K,Hashimura K,Kunikata M,Tanaka T,Huang JW,Mori M

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:The results of chemotherapy in patients with advanced, hormone-refractory prostate cancer (HRPC) have been disappointing. Mitoxantrone has been used in the past for palliation, but it does not prolong survival. It was recently demonstrated that docetaxel is able to improve median survival as compared to mito...

journal_title：Anticancer research

authors： Boehmer A,Anastasiadis AG,Feyerabend S,Nagele U,Kuczyk M,Schilling D,Corvin S,Merseburger AS,Stenzl A

更新日期：2005-11-01 00:00:00

abstract：:Glucose consumption and tritiated thymidine incorporation were monitored for 54 days in histocultured human superficial transitional cell carcinoma of the bladder, indicating that long-term histoculture of human transitional cell carcinoma of the bladder is feasible. The glucose-consumption rate was relatively similar...

journal_title：Anticancer research

authors： Chang SG,Lee JH,Hong DH,Lee HL,Chai SE,Hoffman RM

更新日期：1994-01-01 00:00:00

abstract：:Ovarian tumors of low malignant potential (LMPs) are intermediate between adenomas and ovarian carcinomas (OCs); however, whether an LMP is a precursor of OC or is a unique type of tumor that will not progress to OC is still controversial. To gain better insight into the relationship between LMP and OC, we compared pr...

journal_title：Anticancer research

authors： Nakayama K,Takebayashi Y,Hata K,Fujiwaki R,Iida K,Fukumoto M,Miyazaki K

更新日期：2003-11-01 00:00:00