Abstract:
BACKGROUND/AIM:The effects of inorganic and organic arsenicals on proliferation, cell-cycle distribution, and apoptosis of all-transretinoic acid (ATRA)-resistant human promyelocytic leukemia HL-60 (HL-60-R2) cells were herein investigated. MATERIALS AND METHODS:Cell proliferation was examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cell-cycle distribution and apoptotic cells were analyzed by flow cytometry. RESULTS:The 50% inhibitory concentrations (IC50 values) for As2O3 against proliferation of HL-60 and HL-60-R2 cells were 12.2 and 7.2 μM, while those for arsenate were >200 and 62.1 μM, respectively. In contrast, organic methylarsinic acid, dimethylarsonic acid, trimethylarsine oxide, and tetramethylarsonium did not exert any inhibitory effects even at 200 μM. As2O3 and arsenate increased the proportion of apoptotic cells dose-dependently at a concentration range of 5-200 μM. As2O3 did not activate caspase 3/7 in HL-60 and HL-60-R2 cells. CONCLUSION:As2O3 and arsenate inhibit cell proliferation, affect cell-cycle distribution, and induce apoptosis of ATRA-resistant HL-60-R2 cells. The apoptosis-inducing mechanism appears not to be mediated through caspase3/7.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Sakai C,Arai M,Tanaka S,Onda K,Sugiyama K,Hirano Tsubject
Has Abstractpub_date
2014-11-01 00:00:00pages
6489-94issue
11eissn
0250-7005issn
1791-7530pii
34/11/6489journal_volume
34pub_type
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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更新日期:1985-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
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journal_title:Anticancer research
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doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2015-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2006-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2005-03-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:
更新日期:2006-05-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2010-06-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
更新日期:2000-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,多中心研究
doi:
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doi:
更新日期:2005-11-01 00:00:00
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doi:
更新日期:2000-11-01 00:00:00
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更新日期:2011-04-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
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doi:
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更新日期:2020-08-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
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