Abstract：
BACKGROUND:Aberrant methylation of tumor suppressor gene (TSG) promoters has been extensively investigated in nasopharyngeal carcinomas (NPC) from South East Asia but not from North Africa. PATIENTS AND METHODS:The methylation status of p16, deleted in lung and esophageal cancer (DLEC1), zinc finger, MYND-type containing 10 (BLU) and E-cadherin gene promoters was investigated in 44 Tunisian NPC biopsies and three NPC xenografts, by methylation-specific PCR (MSP) combined with a quantitative assessment of some of the samples. RESULTS:The frequencies of aberrant promoter methylation were similar to previous figures reported for Asian series: p16 27/44 (65%), DLEC1 38/44 (86.3%), BLU 15/44 (34.1%) and E-cadherin 35/44 (79.5%). Although in other malignancies, aberrant promoter hypermethylation increases with patient age, it was at the same high frequency in the juvenile and adult forms of Tunisian NPCs. However, there was a strong association between aberrant methylation of E-cadherin promoter and lymph node invasion (p < 0.01). In addition, aberrant methylation of the BLU promoter was significantly correlated with an undifferentiated histological type (p = 0.03). CONCLUSION:Aberrant methylation of tumor suppressor genes occurs with the same high frequency in NPCs from North Africa as in South East Asia, regardless of patient age.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Ayadi W,Karray-Hakim H,Khabir A,Feki L,Charfi S,Boudawara T,Ghorbel A,Daoud J,Frikha M,Busson P,Hammami Asubject
Has Abstractpub_date
2008-07-01 00:00:00pages
2161-7issue
4Beissn
0250-7005issn
1791-7530journal_volume
28pub_type
杂志文章abstract：BACKGROUND/AIM:Anaplastic thyroid cancer (ATC) is one of the most aggressive human malignancies, remaining generally incurable. Histone deacetylase (HDAC) seems to play a role in regulating transcription of genes involved in ATC, making HDAC inhibitors (HDACI) promising anticancer drugs for ATC. The purpose of this rev...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：10.21873/anticanres.13220
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Nucleophosmin-anaplastic lymphoma kinase expression is associated with a lymphoid malignancy, anaplastic large cell lymphoma, and is characterized by a t(2;5) chromosomal translocation. MATERIALS AND METHODS:We describe a novel transgenic mouse line in which NPM-ALK expression is targeted to the T-cell line...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:We have developed a series of six CTL lines exhibiting preferential killing of autologous tumour cells from tumour-associated lymphocytes (TALs) infiltrating malignant ovarian ascites. Five out of six CTL lines showed increased percentages of V beta 8.1+ cells, four showed increased percentages of V beta 5.3+ cells an...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
abstract：BACKGROUND:The secretory epithelial cells of the prostate gland use sophisticated vehicles in the form of prostasomes to relay important information to sperm cells in semen. This prostasome-forming and secretory ability of the epithelial cells is also preserved in poorly differentiated prostate cancer cells. The aim of...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-02-01 00:00:00
abstract：:Cytochrome P450 CYP2D6 polymorphism is an autosomal recessive trait leading to impaired sparteine/ debrisoquine metabolism in 5-10% of the Caucasian population. Previous studies have associated affected individuals (poor metabolizers = PM) with susceptibility to bladder cancer and various forms of leukemia. In many ot...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND/AIM:The aim of this retrospective study was to detect the frequency, reasons, and significant factors for not receiving immunotherapy after chemoradiotherapy in non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS:Thirty-four patients with NSCLC received definitive chemoradiotherapy. The endpoi...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.14720
更新日期：2020-12-01 00:00:00
abstract：:The overexpression of p53, c-erbB-2 and p21ras gene products was evaluated immunohistochemically in ovarian carcinomas, borderline, and benign neoplasms. All studies were performed on cytospin preparations of cyst and/or ascitic fluid cells and mutual relations between oncoproteins were analysed. p53 and c-erbB-2 immu...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：BACKGROUND:Dehydroepiandrosterone (DHEA) and its analogs have potent chemoprotective actions in mouse skin tumorigenesis models. To assess this association in humans, we investigated the relationship of prediagnostic serum concentrations of DHEA and dehydroepiandrosterone sulfate (DHEAS) to the subsequent risk of devel...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
abstract：:Hormone-dependent (HD) mammary tumors can be induced in mice and rats either by endocrine manipulations or by treatment with carcinogens. The tumors metastasize at a low frequency which may be due to immunogenic properties and does not exclude that the tumors are malignant. Hormone deprival may lead to tumor regressio...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1983-07-01 00:00:00
abstract：BACKGROUND:Mesenchymal stem cells (MSCs) have attracted great interest in cancer therapy since the discovery of their tumor tropism. This study was performed to investigate the effects of TNF-related apoptosis-inducing ligand (TRAIL)-engineered MSCs on hepatocellular carcinoma (HCC) cells (HepG2) under different cultur...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Pure or metaplastic squamous cell carcinoma (SCC) of the breast is a rare entity with an unclear pathogeny and aggressive clinical behaviour. An attempt was made to characterize its differential immunohistochemical and biological profile. PATIENTS AND METHODS:Twenty-seven cases of SCC (pure or not) of the b...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:A large variety of models of both artificial and spontaneous metastases have been developed in experimental animals. These models have enabled the characterization of metastatic cancer cells and have helped in understanding the metastatic process. Studies of experimental metastases of human tumors have so far been rat...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1987-09-01 00:00:00
abstract：BACKGROUND/AIM:Curcumin is a promising nutraceutical for chemoprevention of head and neck squamous cell carcinoma (HNSCC). Capsular formulations of curcumin demonstrate low systemic bioavailability. We aimed to determine if curcumin levels were higher in healthy volunteers and cancer patients with microgranular curcumi...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2015-12-01 00:00:00
abstract：:Prostatic 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-OHase) is up-regulated by epidermal growth factor (EGF) and down-regulated by 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)2D] at the promoter level in an autocrine/paracrine fashion, suggesting that local production of 1alpha,25(OH)2D could provide an important c...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2008-07-01 00:00:00
abstract：:Bone-seeking radionuclides have been used to treat bone pain due to metastatic bone disease for over 40 years. More than 10 clinical studies using radiostrontium (Sr-89) have shown benefit in about 70-80% of patients having refractory bone pain from prostate, breast and other metastatic bone cancers, with minimal hema...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1988-07-01 00:00:00
abstract：:The aim of our study was to establish a simple method for routine analysis of c-erbB-2 gene expression in tumour samples. We constructed a plasmid for the in vitro synthesis of competitor RNA to be used as an internal exogenous control during the RT-PCR detection of c-erbB-2 expression. The competitor RNA harbors a 19...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Oral mucositis is one of the main complications in non-surgical cancer treatments. It represents the major dose-limiting toxicity for some chemotherapeutic agents, for radiotherapy of the head and neck region and for some radiochemotherapy combined treatments. Many reviews and clinical studies have been published in o...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：2007-03-01 00:00:00
abstract：:Four cases of canine lymphoma are presented, including histological examination and cytogenetic investigation. The first case showed a derivative chromosome 13, the second case showed a clonal trisomy 8 and the third case showed a complex karyotype with a clonal trisomy 13 and additional clonal trisomies of the chromo...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：:Metallopanstimulin (MPS) is a 9.5-kDal subunit "zinc finger" protein which is expressed in a wide variety of actively proliferating cells and tumor tissues (J. Biol. Chem. 268:21198-21204, 1993; Cell Growth & Diff. 5:811-825, 1994). A sensitive and specific radioimmunoassay (RIA) has been developed to measure circulat...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:Keratinocytes originating from adult human hair follicles, the most convenient biopsy tissue, can be serially cultured using a combination of two techniques. Primary cultures are established using plucked scalp hair follicles and the bovine eye lens capsule as a growth substrate. Subsequently, cells from these culture...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1983-05-01 00:00:00
abstract：BACKGROUND/AIM:Gefitinib and erlotinib were shown to be particularly effective in a clinically selected subpopulation of non-small cell lung cancer patients (NSCLC): adenocarcinoma histology, non-smoking status, Asian origin and female gender have been associated with improved clinical benefit compared to the unselecte...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:Chemotherapeutic anticancer properties are thought to derive from apoptosis pathway activation and/or cell division arrest, but animal models have also evidenced anti-angiogenic activity in some agents. PATIENTS AND METHODS:The impact of gemcitabine, irinotecan and oxaliplatin + 5-FU upon the serum markers ...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Angiogenesis is involved in the development of cancer, promoting tumor growth, invasiveness and metastasis. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor. The present case control study was carried out, to determine whether there is an association between the VEGF -2578C > A polymor...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
abstract：:The effect of various physiological fluids on the radical intensity of sodium ascorbate and sodium 5,6-benzylidene-L-ascorbate (SBA) was investigated using ESR spectroscopy. Blood from various animals did not significantly affect the radical intensity of both ascorbates, whereas the corresponding plasma fractions sign...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
abstract：:In order to determine the efficacy of liposomal encapsulated daunorubicin (DaunoXome; DNX) in chronic Iymphocytic leukaemia, the sensitivities of cells from 10 patients with this disease were assessed and compared with that of free drug using the MTT assay. There was a marked variation in effect between patients for b...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：OBJECTIVES:In an attempt to find a more sensitive and specific non-invasive diagnostic assay for the detection of bladder cancer cells, the authors assayed the exfoliated cells from patient's voided urine and bladder washing fluids for the presence of telomerase, an enzyme that maintains a cell's chromosomal length, me...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:In human colorectal tissue samples, the gene expressions of 4 coactivators, p300, pCAF, TIF-2 and TRAP 220, and 7 corepressors, N-CoR, REA, MTA1, MTA1L1, HDAC1, HDAC2 and HDAC3, linked to estrogen receptors (ER), were revealed by traditional RT-PCR. Cofactors ERalpha, ERbeta and ERRalpha mRNA levels were then measured...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：:Considerable progress has recently been achieved in understanding the pathogenesis of human immunodeficiency virus type 1 (HIV-1), and in improving the efficacy of antiretroviral therapies for the treatment of patients with the acquired immunodeficiency syndrome (AIDS). The pharmacological properties of new drugs are ...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:The overexpression of syndecan-1 in breast carcinomas correlates with poorer prognosis and an aggressive phenotype. The effect of syndecan-1 expression on tumor response to neoadjuvant chemotherapy was determined in locally advanced breast cancer. PATIENTS AND METHODS:Semi-quantitative syndecan-1 immunohist...
journal_title：Anticancer research
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:CD44 is a transmembrane glycoprotein and is associated with cell-matrix and cell-cell interactions. CD44 expression was shown to be relevant to tumour progression in various types of human cancer. The objective of this study was to investigate the relationship between the expression levels of the standard fo...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
