Abstract:
:Osteosarcoma of the jaw is a rare disease; we report two cases, one in which the primary osteosarcoma had occurred in the sacrum and ileum, the second at the mandible. Dissemination of osteosarcoma to other organs, especially early dissemination to the lung, is common, but metastasis to the jaw has only rarely been reported. About 10% of osteosarcomas occur in the head and neck, most in the mandible or maxilla. Clinically, both patients presented swelling, and pain at the jaw in the premolar-molar region. At radiography, extensive bone erosion and soft-tissue swelling were apparent. A biopsy was taken and a diagnosis of osteosarcoma rendered in both cases. Histological examination revealed a proliferation of atypical osteoblast-like cells with hyperchromatic nuclei and formation of scattered neoplastic osteoid tissue. Immunohistochemistry for a panel of antibodies showed strong positivity for CD99, weak positivity for S-100, but was negative for desmin, vimentin, and cytokeratins. The diagnosis for both cases was of osteogenic osteosarcoma, chondroblastic subtype. Unfortunately, both patients died, one before the planned chemotherapy regime could begin, the second during the chemotherapy course. Our report aims to highlight the importance of the diagnostic profile in formulating a diagnosis of osteosarcoma, and that this tumor, although very rare, may be primary or may metastasize to the jaws.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Angiero F,Moltrasio F,Cattoretti G,Valente MGsubject
Has Abstractpub_date
2011-12-01 00:00:00pages
4485-9issue
12eissn
0250-7005issn
1791-7530pii
31/12/4485journal_volume
31pub_type
杂志文章abstract::The antitumor effects of the somatostatin structural derivative TT-232 in different rodent and xenograft tumor models are summarized in this report. TT-232 had previously been shown to inhibit the proliferation of a large number of cancer cell lines in vitro and reduce the size of different tumors in animal models in ...
journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2006-09-01 00:00:00
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journal_title:Anticancer research
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pub_type: 杂志文章,多中心研究
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更新日期:2016-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
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更新日期:2013-12-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:Anticancer research
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2013-10-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2009-12-01 00:00:00
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journal_title:Anticancer research
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-07-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2009-12-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00
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doi:
更新日期:2009-10-01 00:00:00
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更新日期:2016-09-01 00:00:00
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pub_type: 临床试验,杂志文章,评审
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更新日期:1981-01-01 00:00:00
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