Abstract：
BACKGROUND/AIM:Rta, a transactivator of Epstein-Barr virus, is associated with progression of nasopharyngel carcinoma (NPC); however, its mechanism of contribution to the pathogenesis of NPC remains unclear. Interleukin-6 (IL-6), a tumor promoter, is detected in NPC. This in vitro study examined whether and how Rta promotes NPC progression by up-regulating IL-6. MATERIALS AND METHODS:Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR), quantitative real-time PCR, ELISA, immunoblotting assays, reporter gene assays, and transwell migration assays were performed. RESULTS:In NPC cells, Rta up-regulated IL-6 expression at the mRNA and protein levels, and the Rta's C-terminus was essential for promoter activation and expression of IL-6. The induction of IL-6 by Rta also required activation of extracellular signal-regulated kinase 1/2 and activator protein-1. Furthermore, IL-6 secreted from Rta-expressing NPC cells promoted migration of Rta-negative NPC cells by activating IL-6 receptor/Janus kinase/signal transducer and activator of transcription 3 pathway. CONCLUSION:Rta contributes to progression of NPC cells through induction of IL-6 in vitro.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Tung KL,Wu YT,Liu C,Lin SC,Wu CH,Wu SY,Chang Y,Lan YYdoi
10.21873/anticanres.14307subject
Has Abstractpub_date
2020-06-01 00:00:00pages
3255-3264issue
6eissn
0250-7005issn
1791-7530pii
40/6/3255journal_volume
40pub_type
杂志文章abstract：:Concurrent cisplatin-based chemotherapy and radiotherapy (CCRT) plus brachytherapy is standard treatment for locally advanced cervical cancer. Platinum-based neoadjuvant chemotherapy (NACT) followed by radical hysterectomy has been proposed as an alternative approach, especially for patients with stage Ib2-IIb disease...
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doi：
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doi：
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doi：
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更新日期：2017-02-01 00:00:00
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