Distribution and Effects of CDKN2 p16 540 C>G and 580 C>T, and MDM2 SNP309 T>G Polymorphisms in Patients with Primary Brain Tumors.

abstract：BACKGROUND:Metastatic involvement of the pancrease is not an uncommon autopsy finding, however, pancreatic metastasis is an infrequent clinical condition and the pattern of the metastases have not been studied. We conducted a retrospective study in order to evaluate the pattern of the metastasis from lung cancer. PATI...

journal_title：Anticancer research

authors： Maeno T,Satoh H,Ishikawa H,Yamashita YT,Naito T,Fujiwara M,Kamma H,Ohtsuka M,Hasegawa S

更新日期：1998-07-01 00:00:00

abstract：:We report on a case of low-grade periductal stromal tumor of the breast with synchronous bilateral breast carcinoma. A 45-year-old woman came to our Hospital because of a palpable mass of the right breast. An approximately 5-cm mass was palpated in the upper right breast. The mammographic and sonographic findings of t...

journal_title：Anticancer research

authors： Ki SY,Lim HS,Lee JS,Park SY,Yim NY,Heo SH,Park MH,Cho JS,Shin SH

更新日期：2014-07-01 00:00:00

abstract：:During follow-up examinations for breast cancer the serum tumor marker CA 125 was measured routinely in the Universitätsfrauenklinik Erlangen. We found elevated CA 125 levels in 18 of 510 clinical asymptomatic patients. These patients were followed closely. A second malignant neoplasm was found in six of these patient...

journal_title：Anticancer research

authors： Böhmer C,Jäger W,Lang N

更新日期：1997-07-01 00:00:00

abstract：AIM:We report a retrospective evaluation for patients with stage IVB cervical cancer in order to identify survival rates and to improve our current practice. PATIENTS AND METHODS:We analyzed 85 patients with stage IVB cervical cancer. For patients appropriate for radical treatment, a combination of external-beam radio...

journal_title：Anticancer research

authors： Oishi S,Kudaka W,Toita T,Ariga T,Nakamoto T,Wakayama A,Nagai Y,Kaneshima I,Nishihira K,Aoki Y

更新日期：2016-07-01 00:00:00

abstract：:MUC1 (DF3 antigen) is a member of a family of high molecular weight glycoproteins. Recent studies have demonstrated that MUC1 is expressed in tumors of various human organs and may function as an anti-adhesion molecule that inhibits cell-to-cell adhesion, inducing tumor metastasis. However, expression patterns of MUC1...

journal_title：Anticancer research

authors： Kijima H,Chino O,Oshiba G,Tanaka H,Kenmochi T,Kise Y,Shimada H,Abe Y,Tokunaga T,Yamazaki H,Nakamura M,Tanaka M,Makuuchi H,Ueyama Y

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Sweet's syndrome (SS) is a febrile neutrophilic dermatosis that has been clinically linked to hematological malignancies, particularly myelodysplastic syndrome (MDS), in a number of case series. Many epigenetic changes underlying MDS have been identified, such as a mutation in the isocitrate dehydrogenase 1 ...

journal_title：Anticancer research

authors： Snyder R,Libby T,Raciti P,Amin B,Jacobson M,Rakheja D,Fleming K,Bartenstein M,Zhu C,Goel S,Verma AK,Shastri A

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Licofelone, a potent antiinflammatory agent has been reported to interfere with the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) signaling pathways with few side-effects. However, the underlying mechanism of licofelone against human cancer is not understood. MATERIALS AND METHODS:Human and mouse pros...

journal_title：Anticancer research

authors： Narayanan NK,Nargi D,Attur M,Abramson SB,Narayanan BA

更新日期：2007-07-01 00:00:00

abstract：:Megakaryocyte polyploidization responds to platelet demand and results from the lack of cytoplasmic separation while the nucleus keeps dividing. In normal telophase, the plane of the actin constriction ring is determined by the tubulin spindle. In order to investigate the role of tubulin in the megakaryocyte polyploid...

journal_title：Anticancer research

authors： Baatout S,Chatelain B,Staquet P,Symann M,Chatelain C

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:The present study investigated the mechanism underlying the apoptosis of MKN28 human gastric cancer cells induced by the phosphatidylinositol (PI) derivative 1,2-O-bis-[8-{2-(2-pentyl-cyclopropylmethyl)-cyclopropyl}-octanoyl]-sn-glycero-3-phosphatidyl-D-1-inositol (diDCP-LA-D-PI) and its enantiomer diDCP-LA-...

journal_title：Anticancer research

authors： Ohyama M,Tsuchiya A,Kaku Y,Kanno T,Shimizu T,Tanaka A,Nishizaki T

更新日期：2015-12-01 00:00:00

abstract：:This review summarizes our experiments which are investigating the relationship between the structure and activity of mainly phenothiazines, benzo[a]phenothiazines and benz[c]acridines. Phenothiazines had potent antiplasmid and antibacterial activities, but induced weak antimicrobial activity in vivo. Their antiplasmi...

journal_title：Anticancer research

authors： Molnár J,Sakagami H,Motohashi N

更新日期：1993-07-01 00:00:00

abstract：:Serially propagated fibroblast clones were treated with 25-mM methionine and a thioguanine resistance assay was performed at each passage to measure mutagenesis at the HGPRT locus. The spontaneous frequency of thioguanine resistant mutants before treatment was less than 5 X 10(-6) in four clones and 22 X 10(-6) in one...

journal_title：Anticancer research

authors： Hill M,Hillova J,Mariage-Samson R,Brada Z

更新日期：1988-07-01 00:00:00

abstract：:In human colorectal tissue samples, the gene expressions of 4 coactivators, p300, pCAF, TIF-2 and TRAP 220, and 7 corepressors, N-CoR, REA, MTA1, MTA1L1, HDAC1, HDAC2 and HDAC3, linked to estrogen receptors (ER), were revealed by traditional RT-PCR. Cofactors ERalpha, ERbeta and ERRalpha mRNA levels were then measured...

journal_title：Anticancer research

authors： Giannini R,Cavallini A

更新日期：2005-11-01 00:00:00

abstract：:We report a case of mucoepidermoid carcinoma of the trachea in a 23-year-old pregnant female in her 39th week. The patient had cough and wheezing in the early morning for 9 months before admission. No abnormalities were detected on a chest roentgenogram. At Caesarean section, fiberscopy revealed a polypoid lesion narr...

journal_title：Anticancer research

authors： Watanabe M,Tomita K,Burioka N,Yajima H,Nakamura H,Ohgi S,Shimizu E

更新日期：2000-05-01 00:00:00

abstract：AIM:To describe the feasibility, safety, and oncological outcomes of a modified triple-incision total radical vulvectomy and inguino-femoral lymphadenectomy in patients with locally advanced squamous vulvar cancer. PATIENTS AND METHODS:A modified triple-incision technique performed by two surgical teams operating simu...

journal_title：Anticancer research

authors： Fambrini M,Sorbi F,Sisti G,Checcucci V,Cariti G,Scotti V,Tinacci E,Turrini I,Micaglio M,De Magnis A

更新日期：2014-12-01 00:00:00

abstract：:Medullary thyroid cancer (MTC) is a rare but aggressive thyroid malignancy. The gold-standard biomarker for its diagnosis and follow-up is calcitonin (CT); however, it has a variable half-life dependent on its circadian variability. It has been suggested that a more stable hormone, procalcitonin (PCT), may overcome th...

journal_title：Anticancer research

authors： Karagiannis AK,Girio-Fragkoulakis C,Nakouti T

更新日期：2016-08-01 00:00:00

abstract：:In screening cytotoxic agents in morphine alkaloids [TE1-10], codeinone [TE8] was cytotoxic against two human oral tumor cells lines (HSC-2 and HSG). The cytotoxic activity of codeinone (CC50=1.0-1.2 microg/mL) against HSC-2 or HSG cells was higher than that of doxorubicin (CC50=1.9-2.0 microg/mL). Human oral gingival...

journal_title：Anticancer research

authors： Kawase M,Sakagami H,Furuya K,Kikuchi H,Nishikawa H,Motohashi N,Morimoto Y,Varga A,Molnár J

更新日期：2002-01-01 00:00:00

abstract：AIM:The American thyroid association (ATA) recommends that additional imaging procedures supplement cervical ultrasonography (US) in any patient with a basal calcitonin value above 150 pg/ml in the follow-up of medullary thyroid carcinoma (MTC). The aim of the present study was to reaffirm or challenge this cut-off for...

journal_title：Anticancer research

authors： Sesti A,Mayerhoefer M,Weber M,Anner P,Wadsak W,Dudczak R,Haug A,Karanikas G

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Paclitaxel pharmacokinetics were shown to be related to toxicity and survival. PATIENTS AND METHODS:We evaluated the effects of time above paclitaxel concentrations of 0.05 micromol/l (T(>0.05) and systemic exposures (AUC) to total and unbound paclitaxel (tPAC, uPAC) on response in patients with advanced ca...

journal_title：Anticancer research

authors： Mielke S,Sparreboom A,Behringer D,Mross K

更新日期：2005-11-01 00:00:00

abstract：:Glioblastomas are the most frequent and most malignant astrocytic gliomas. The epidermal growth factor receptor (EGFR) gene is the most frequently amplified and overexpressed in glioblastomas. The expression of bcl-2 and Bax in EGFR-antisense transfected and un-transfected glioblastoma cell line, U87E and U87V was stu...

journal_title：Anticancer research

authors： Wang ZH,Ding MX,Yuan JP,Jin ML,Hao CF,Chew-Cheng SB,Ng HK,Chew EC

更新日期：1999-09-01 00:00:00

abstract：:The effect of various physiological fluids on the radical intensity of sodium ascorbate and sodium 5,6-benzylidene-L-ascorbate (SBA) was investigated using ESR spectroscopy. Blood from various animals did not significantly affect the radical intensity of both ascorbates, whereas the corresponding plasma fractions sign...

journal_title：Anticancer research

authors： Satoh K,Ida Y,Asano K,Hisamitsu T,Inagaki M,Sho S,Kochi M,Tanaka T,Sakagami H

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Oxaliplatin (L-OHP), active in a wide range of human and animal tumours, also CDDP-resistant, possesses unique molecular characteristics of action. However, the mechanisms by which the damage induced by L-OHP triggers a death signal are not yet fully defined. MATERIALS AND METHODS:After L-OHP treatment of t...

journal_title：Anticancer research

authors： Marchetti P,Galla DA,Russo FP,Ricevuto E,Flati V,Porzio G,Ficorella C,Cifone MG

更新日期：2004-01-01 00:00:00

abstract：:Twelve inoperable lung cancer patients were treated with a combination chemotherapy of cisplatinum (CDDP) and etoposide (VP16), as a continuous infusion for 5 days, every 21 days, and with a daily oral administration of GaCl3. Dosages of CDDP and VP16 were adapted in order to obtain an area under the curve (AUC) of 80...

journal_title：Anticancer research

authors： Collery P,Morel M,Desoize B,Millart H,Perdu D,Prevost A,Vallerand H,Pechery C,Choisy H,Etienne JC

更新日期：1991-07-01 00:00:00

abstract：:Although growth factors are acknowledged for their mitogenic activity, a number of other functions are fulfilled by such peptides. These include control of motile and invasive behaviour, angiogenesis and phenotype. Various growth factors including epidermal growth factor, fibroblast growth factor, platelet derived gro...

journal_title：Anticancer research

authors： Finn PE,Bjerkvig R,Pilkington GJ

更新日期：1997-11-01 00:00:00

abstract：:CA 72-4 is a high molecular weight, pancarcinoma human tumor mucin which may play an important role in the identification (i.e., staging) and clinical management of patients with gastric carcinoma. In the present study of 242 patients with primary or recurrent gastric cancer, a higher percentage of these patients had ...

journal_title：Anticancer research

authors： Spila A,Roselli M,Cosimelli M,Ferroni P,Cavaliere F,Arcuri R,Tedesco M,Carlini S,D'Alessandro R,Perri P,Casciani CU,Greiner JW,Schlom J,Guadagni F

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND/AIM:Despite an expected prognostic disadvantage for upper tract versus lower tract metastatic urothelial carcinomas (UTUC/LTUC), only few studies have been conducted to elucidate potential differences in chemotherapy treatment. PATIENTS AND METHODS:A post-hoc subgroup analysis of a non-interventional study ...

journal_title：Anticancer research

authors： Heers H,DE Geeter P,Goebell PJ,Matz U,DE Schultz W,Edlich B,Retz M,Hegele A

更新日期：2017-11-01 00:00:00

abstract：:Pseudomyxoma peritonei (PMP) is a clinical condition characterized by diffuse intraabdominal spread of mucinous tumor implants that form on peritoneal surfaces. To complement the efficacy of cytoreductive surgery, an effective cytotoxic drug is required as an intraperitoneal agent for microscopic cytoreduction locoreg...

journal_title：Anticancer research

authors： Chua TC,Akther J,Yao P,Morris DL

更新日期：2009-10-01 00:00:00

abstract：:NMR spectroscopy was used to analyse perchloric acid extracts of normal human brain, murine brain cell cultures, glioblastoma tissue and the glioblastoma cell line U-87. 1H NMR spectra revealed the presence of elevated levels of UDP-N-acetylglucosamine and UDP-N-acetylgalactosamine in glioblastoma extracts and the gli...

journal_title：Anticancer research

authors： Sonnewald U,Isern E,Gribbestad IS,Unsgård G

更新日期：1994-05-01 00:00:00

abstract：:Curcumin and its reduced derivative tetrahydrocurcumin have been shown to exhibit chemopreventive activity. Cyclooxygenase-2 (COX-2) inhibition in lipopolysaccharide (LPS)- or Porphyromonas gingivalis fimbria-stimulated RAW 264.7 cells was investigated using Northern blot analysis. The fimbria-stimulated expression of...

journal_title：Anticancer research

authors： Murakami Y,Ishii H,Takada N,Tanaka S,Machino M,Ito S,Fujisawa S

更新日期：2008-03-01 00:00:00

abstract：:Tricot et al have reported that the nucleoside analog tiazofurin can induce hematologic remissions in patients with chronic myelogenous leukemia in blast crisis (CML-BC). These reports prompted us to begin a derivative, phase II trial of tiazofurin in CML-BC to determine if the promising findings reported by these inv...

journal_title：Anticancer research

authors： Wright DG,Boosalis MS,Waraska K,Oshry LJ,Weintraub LR,Vosburgh E

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:The risk of chronic obstructive pulmonary disease (COPD) is related to Gc protein allele type, such as Gc*1F, Gc*IS, Gc*2. It has been reported that Gc*1F increased COPD risk, while Gc*2 suppressed the risk. Thus, the allele type of Gc protein is an important factor in COPD. These Gc proteins differ in sugar...

journal_title：Anticancer research

authors： Ohkura K,Nagasawa H,Uto Y,Okamura N,Murakami A,Hori H

更新日期：2006-11-01 00:00:00