Apoptosis induced by oxaliplatin in human colon cancer HCT15 cell line.

abstract：:We assessed the prognostic value of the local tumor characteristics inflammatory stromal reaction (ISR) and vascular space invasion (VSI) together with established prognostic criteria, in cervical cancer patients. One hundred and forty-two patients with carcinoma of the cervix stage IB to IIB undergoing radical hyster...

journal_title：Anticancer research

authors： Kainz C,Gitsch G,Tempfer C,Heinzl H,Koelbl H,Breitecker G,Reinthaller A

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND/AIM:Our original hypothesis was that the rectus sheath block (RSB) analgesia could enhance patient satisfaction and decrease pain following midline laparotomy. PATIENTS AND METHODS:Initially, 56 patients were randomized into four groups; control group (n=12), single-dose (n=16), repeated-dose (n=12) and con...

journal_title：Anticancer research

authors： Kuosmanen V,Ruottinen M,Rahkola D,Saimanen I,Kaaronen V,Selander T,Purdy M,Kokki H,Kokki M,Eskelinen M

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND/AIM:For cases of musculoskeletal sarcoma of the knee presenting to our institute, we prioritize joint preservation whenever possible. To investigate patient satisfaction and desire for joint preservation, a questionnaire survey was performed. PATIENTS AND METHODS:Surveys were mailed to 62 patients with musc...

journal_title：Anticancer research

authors： Abe K,Yamamoto N,Hayashi K,Takeuchi A,Kato S,Miwa S,Igarashi K,Inatani H,Aoki YU,Higuchi T,Taniguchi Y,Tsuchiya H

更新日期：2019-04-01 00:00:00

abstract：AIM:Metabolic syndrome has been identified as a risk factor for colorectal cancer and adenoma. The aim of our study was to assess the risk of colorectal cancer and adenoma in an adult Italian population with metabolic syndrome. PATIENTS AND METHODS:Ninety patients with metabolic syndrome were prospectively compared ag...

journal_title：Anticancer research

authors： Fiori E,Lamazza A,De Masi E,Schillaci A,Crocetti D,Antoniozzi A,Sterpetti AV,De Toma G

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND/AIM:Changes in epidermal growth factor receptor (EGFR) are commonly found in cancer progression, signaling a poor outcome in patients. In the present study, we aimed to investigate whether nimotuzumab could be of benefit for cholangiocarcinoma (CCA) treatment. MATERIALS AND METHODS:The expression of EGFR wa...

journal_title：Anticancer research

authors： Padthaisong S,Thanee M,Techasen A,Namwat N,Yongvanit P,Liwatthakun A,Hankla K,Sangkhamanon S,Loilome W

更新日期：2017-07-01 00:00:00

abstract：:2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant that induces various types of immunotoxicity. One effect of exposure to this contaminant is alteration in cell adhesiveness. Leukocyte function-associated antigen-1 (LFA-1) plays an important role not only in T-cell recruitment into s...

journal_title：Anticancer research

authors： Park SJ,Yoon WK,Son HY,Cho SW,Jung JY,Jeong KS,Kim TH,Kim SH,Ryu SY

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND/AIM:Basaloid squamous cell carcinoma of the oesophagus (BSCCE) is a variant of oesophageal squamous cell carcinoma (ESCC), that has a more aggressive biological behaviour than that of typical ESCC. miR-3687 has been previously identified to be highly expressed in BSCCE. This study aimed to evaluate the progn...

journal_title：Anticancer research

authors： Hagio K,Furuya S,Nakamura J,Maruyama S,Shiraishi K,Shimizu H,Akaike H,Hosomura N,Kawaguchi Y,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Ichikawa D

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND/AIM:Rta, a transactivator of Epstein-Barr virus, is associated with progression of nasopharyngel carcinoma (NPC); however, its mechanism of contribution to the pathogenesis of NPC remains unclear. Interleukin-6 (IL-6), a tumor promoter, is detected in NPC. This in vitro study examined whether and how Rta pro...

journal_title：Anticancer research

authors： Tung KL,Wu YT,Liu C,Lin SC,Wu CH,Wu SY,Chang Y,Lan YY

更新日期：2020-06-01 00:00:00

abstract：:Colchicine is an alkaloid widely used for the treatment of inflammatory diseases, such as gout. It suppresses cell division by inhibiting mitosis. We investigated the anticancer effects of colchicine on human hypopharyngeal cancer cells and the mechanisms underlying its anticancer effects. XTT cell proliferation assay...

journal_title：Anticancer research

authors： Cho JH,Joo YH,Shin EY,Park EJ,Kim MS

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Human herpesviruses types 4 and 6 (EBV, HHV-6) are frequently found in Hodgkin 's disease (HD) and--to a certain extent--in Kikuchi-Fujimoto's disease (KFD). Both viruses are apparently related to proliferative and/or apoptotic processes as represented by HD or KFD respectively. OBJECTIVE:To correlate frequ...

journal_title：Anticancer research

authors： Krueger GR,Huetter ML,Rojo J,Romero M,Cruz-Ortiz H

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) directed against epidermal growth factor receptor (EGFR) are important in the treatment of non-small cell lung cancer (NSCLC), especially those harboring EGFR mutations. But little is known regarding the clinical value of serum tumor marker levels measured prior to treatment...

journal_title：Anticancer research

authors： Takeuchi A,Oguri T,Sone K,Ito K,Kitamura Y,Inoue Y,Asano T,Fukuda S,Kanemitsu Y,Takakuwa O,Ohkubo H,Takemura M,Maeno K,Ito Y,Niimi A

更新日期：2017-10-01 00:00:00

abstract：:Although growth factors are acknowledged for their mitogenic activity, a number of other functions are fulfilled by such peptides. These include control of motile and invasive behaviour, angiogenesis and phenotype. Various growth factors including epidermal growth factor, fibroblast growth factor, platelet derived gro...

journal_title：Anticancer research

authors： Finn PE,Bjerkvig R,Pilkington GJ

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Interleukin-1alpha (IL-1) is known to radioprotect the gastrointestinal tract, but the mechanism by which this protection occurs remains unclear. These studies were undertaken to investigate whether the radioprotective potential of IL-1 may be linked to an ability to reduce apoptosis within the gastrointesti...

journal_title：Anticancer research

authors： Johnke RM,Smith ES,Cariveau MJ,Evans MJ,Kilburn JM,Bakken NT,Nangami GN

更新日期：2008-11-01 00:00:00

abstract：:This review describes the use of murine polyomavirus "virus-like" particles (MPyV-VLPs), free from viral genes, as vectors for gene and immune therapy and as vaccines. For large-scale MPyV-VLP manufacture, VP1 is produced in a baculovirus insect cell system, E. coli or in yeast. MPyV-VLPs bind eukaryotic DNA and intro...

journal_title：Anticancer research

authors： Tegerstedt K,Franzén AV,Andreasson K,Joneberg J,Heidari S,Ramqvist T,Dalianis T

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:The pS2 protein is involved in the maintenance of the integrity of the gastrointestinal tract. In breast cancer pS2 can be demonstrated in at least half of the tumors and probably reflects the functional status of ER. Several features make it likely that pS2 is involved in growth regulation. PATIENTS AND ME...

journal_title：Anticancer research

authors： Jansen RL,Hupperets PS,Arends JW,Joosten-Achjanie SR,Volovics A,Hillen HF,Schouten HC

更新日期：1998-01-01 00:00:00

abstract：:Using serum-free conditions, human monocyte-derived dendritic cells (MoDCs) tend to mature insufficiently in a T(H)1-polarizing direction under approved and standardized clinical conditions. However, for the initiation of an efficient tumour antigen-specific cytotoxic T-cell response, the induction of a distinct T(H)1...

journal_title：Anticancer research

authors： Hildenbrand B,Lorenzen D,Sauer B,Hertkorn C,Freudenberg MA,Peters JH,Nesselhut T,Unger C,Azemar M

更新日期：2008-05-01 00:00:00

abstract：:Three sublines have been derived from the parental line Mv1Lu by transfection with normal and mutated Ha-ras, and myc oncogenes, and subsequent cloning. All the oncogenes have increased the growth rate of the cell in vitro, increased their plating efficiency in monolayer and suspension, and reduced their serum depende...

journal_title：Anticancer research

authors： Khan MZ,Spandidos DA,Kerr DJ,McNicol AM,Lang JC,De Ridder L,Freshney RI

更新日期：1991-05-01 00:00:00

abstract：:Although some types of intestinal metaplasia are considered to be potentially pre-malignant lesions leading to gastric carcinoma, their high frequency and variability limit their usefulness as early markers of malignant progression. The present study was carried out to search for parameters which could be used in conj...

journal_title：Anticancer research

authors： Blasco-Olaetxea E,Loizate A,Eizagirre B,Garcia-Tamayo J

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND/AIM:Curcumin is a promising nutraceutical for chemoprevention of head and neck squamous cell carcinoma (HNSCC). Capsular formulations of curcumin demonstrate low systemic bioavailability. We aimed to determine if curcumin levels were higher in healthy volunteers and cancer patients with microgranular curcumi...

journal_title：Anticancer research

authors： Latimer B,Ekshyyan O,Nathan N,Moore-Medlin T,Rong X,Ma X,Khandelwal A,Christy HT,Abreo F,McClure G,Vanchiere JA,Caldito G,Dugas T,McMartin K,Lian T,Mehta V,Nathan CA

更新日期：2015-12-01 00:00:00

abstract：:Estrogen analogues, moxestrol (10(-8)-10(-5) M) and ethinyl estradiol (10(-8)-10(-6) M), produced a 30% and 15% inhibition of LoVo cell growth, respectively, in serum-free Ham's F-10 medium. Under the same conditions, no growth effects were observed on these cells following the addition of progesterone or testosterone...

journal_title：Anticancer research

authors： Lointier P,Wildrick DM,Boman BM

更新日期：1992-07-01 00:00:00

abstract：:Growth inhibitory activity of YM881 (SMANCS) against 3 human cultured cell lines and one rat cultured cell line derived from glioma cells was assessed quantitatively. YM881 showed potent cytotoxicity against all glioma cell lines tested; the IC50 of this drug was 1.9-8.4 micrograms/ml. YM881 may be classified as a con...

journal_title：Anticancer research

authors： Kuratsu J,Takaki S,Kochi M,Mihara Y,Ushio Y

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:The concentration of Des-gamma-carboxy-prothrombin (DCP) or PIVKA-II has been described to be increased in patients with hepatocellular cancer, along with its elevation in vitamin K deficient states by warfarin or dicoumarol treatment. The aim of the study was to investigate its clinical value in HCC in comp...

journal_title：Anticancer research

authors： Lamerz R,Runge M,Stieber P,Meissner E

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND/AIM:We have previously reported that doxorubicin (DXR) showed much higher cytotoxicity against human oral squamous cell carcinoma cell lines compared to normal human mesenchymal normal oral cells (gingival fibroblast, periodontal ligament fibroblast, pulp cell), yielding high tumor-specificity. However, we u...

journal_title：Anticancer research

authors： Sakagami H,Okudaira N,Masuda Y,Amano O,Yokose S,Kanda Y,Suguro M,Natori T,Oizumi H,Oizumi T

更新日期：2017-03-01 00:00:00

abstract：:The effects of all-trans retinoic acid (ATRA), either alone or in combination with GM-CSF, on the induction of differentiation of a human myeloblastic leukemia cell line, ML-1, were investigated. ATRA alone caused only slight induction of NBT-reducing activity even at a high concentration (10(-7) M), but when combined...

journal_title：Anticancer research

authors： Oka Y,Takeda K

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:The etiology of ovarian cancer is not fully understood. Polymorphisms in low penetrance genes involved in carcinogen and estrogen metabolism are hypothesized to play a role in the initiation of carcinogenesis. PATIENTS AND METHODS:A case-control study was conducted to investigate the role of these polymorph...

journal_title：Anticancer research

authors： Delort L,Chalabi N,Satih S,Rabiau N,Kwiatkowski F,Bignon YJ,Bernard-Gallon DJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Medullary thyroid carcinoma (MTC) is a calcitonin-producing tumor of the parafollicular C-cells, accounting for 5-10% of all thyroid tumors. To date, the only effective treatment is the early and total surgical removal of all neoplastic tissue. As the prognosis of patients with advanced MTC, unresectable or ...

journal_title：Anticancer research

authors： Pfragner R,Skofitsch G,Höger H,Jech M,Rinner B,Siegl V,Niederle B,Gnant M,Friedl J,Stift A

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND/AIM:Multidrug resistance (MDR) is often associated with overexpression of P-glycoprotein (ABCB1) in cancer cells. Apatinib is a novel Vascular endothelial growth factor receptor-TKI (VEGFR-TKI) which inhibits the function of ABCB1 in certain cancers. This study aimed to investigate the effect of apatinib on ...

journal_title：Anticancer research

authors： Zhang Q,Song Y,Cheng X,Xu Z,Matthew OA,Wang J,Sun Z,Zhang X

更新日期：2019-10-01 00:00:00

abstract：AIM:To improve the treatment of transmissible venereal tumors (TVTs) in dogs with intratumoral injections of interleukin-2 (IL-2). PATIENTS AND METHODS:We treated 13 dogs with 18 natural TVTs with IL-2. The tumors were treated with intratumoral application of 2×10(6) units IL-2. RESULTS:Three months after injection o...

journal_title：Anticancer research

authors： Den Otter W,Hack M,Jacobs JJ,Tan JF,Rozendaal L,Van Moorselaar RJ

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND/AIM:Since androgens affect urothelial bladder cancer (UBC), we examined whether 5α-reductases (5-AR) have genomic alterations in UBC and whether 5α-reductase inhibitors (5-ARI) affect UBC. MATERIALS AND METHODS:The cBioPortal was used to analyze genomic alternations of 5-ARs in UBC cancer genomic datasets. ...

journal_title：Anticancer research

authors： Chen CC,Huang CP,Tsai YT,Hseih TF,Shyr CR

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND/AIM:Hepatic venous isolation and extracorporeal charcoal hemoperfusion (HVI-CHP) can reduce systemic exposure to hepatic arterial infusion (HAI) chemotherapy. The pre-existing HVI-CHP system has limited effectiveness against high-dose cisplatin; therefore, we designed a new system and evaluated its efficacy ...

journal_title：Anticancer research

authors： So S,Komatsu S,Takebe A,Kido M,Tanaka M,Toyama H,Ueno K,Fukumoto T

更新日期：2018-11-01 00:00:00