Abstract:
BACKGROUND/AIM:Hepatic venous isolation and extracorporeal charcoal hemoperfusion (HVI-CHP) can reduce systemic exposure to hepatic arterial infusion (HAI) chemotherapy. The pre-existing HVI-CHP system has limited effectiveness against high-dose cisplatin; therefore, we designed a new system and evaluated its efficacy in a canine model. MATERIALS AND METHODS:Cisplatin was administered via HAI under HVI-CHP. HVI-CHP was performed using one charcoal column in group I and two charcoal columns in group II; it was not performed in group III. The plasma cisplatin levels in the systemic circulation and at the column inlet and outlet, and the column extraction rate of were analyzed. RESULTS:The column extraction rates of free and total cisplatin in group II were significantly higher than those in group I. The systemic concentration of free cisplatin was significantly lower in group II than in groups I and III after HAI. No significant differences were observed in cisplatin concentrations in the liver tissue among all groups. CONCLUSION:A novel HVI-CHP system for HAI of cisplatin was successfully developed.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
So S,Komatsu S,Takebe A,Kido M,Tanaka M,Toyama H,Ueno K,Fukumoto Tdoi
10.21873/anticanres.13006subject
Has Abstractpub_date
2018-11-01 00:00:00pages
6445-6452issue
11eissn
0250-7005issn
1791-7530pii
38/11/6445journal_volume
38pub_type
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journal_title:Anticancer research
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