Identification of metastasis-associated genes by transcriptional profiling of metastatic versus non-metastatic colon cancer cell lines.

Abstract:

:In order to define genes which mediate liver tropism of colon cancer metastasis we have compared the transcriptional profile of 5600 full-length genes using the Affymetrix HuGene FL array technology of the non-metastatic colon cancer cell lines KM12C and the two metastatic cell lines, KM12SM and KM12L4A, which are derived from KM12C. We present data on genes which are up- and downregulated in the metastatic cell line and those which are selectively upregulated in one of the metastatic cell lines. We have sub-grouped the deregulated genes into different categories, such as immune response, modulation of transcription, enzymes, cell cycle/apoptosis, interferon- and tumor necrosis factor-regulated genes, tumor antigens and transmembrane receptors, intracellular signaling, cytoskeleton and extracellular matrix associated proteins, 'others' and genes of unknown function.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

De Lange R,Burtscher H,Jarsch M,Weidle UH

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

2329-39

issue

4A

eissn

0250-7005

issn

1791-7530

journal_volume

21

pub_type

杂志文章
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    authors: Heiss P,Bernatz S,Bruchelt G,Senekowitsch-Schmidtke R

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    authors: Taba K,Kuramitsu Y,Ryozawa S,Yoshida K,Tanaka T,Maehara S,Maehara Y,Sakaida I,Nakamura K

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    journal_title:Anticancer research

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    doi:10.21873/anticanres.11831

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    doi:

    authors: Merle P,Morvan D,Caillaud D,Demidem A

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    authors: Gratas C,Powis G

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    authors: Mattern J,Edler L,Volm M

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  • Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.

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    authors: Pulkkinen JO,Klemi P,Martikainen P,Grénman R

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