Correlation of cell proliferation marker (TPS), natural killer (NK) activity and tumor load serotest (PSA) in untreated and treated prostatic tumors.

abstract：BACKGROUND/AIM:4-methylumbelliferone (4-MU) has received considerable attention due to its potential for cancer treatment since it inhibits cell proliferation, migration and invasion. An increasing body of evidence suggests that extracellular matrix (e.g. hyaluronan) and nutrients (e.g. glucose) in the tumor microenvir...

journal_title：Anticancer research

authors： Wang R,Zhou W,Wang J,Liu Y,Chen Y,Jiang S,Luo X,Stupack DG,Luo N

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary disease with complete penetrance and a very variable phenotype. Recent research has shown that postzygotic NF1 gene mutations occur to a far greater extent than previously thought. The phenotype of affected individuals reflects the time of so...

journal_title：Anticancer research

authors： Friedrich RE,Hagel C,Kohlrusch FK,Schanze I,Wieland I,Zenker M

更新日期：2020-06-01 00:00:00

abstract：:Alterations in histone acetylation status appear to play a central role in the regulation of neoplasia, tumor suppression, cell cycle control, hormone responsiveness and senescence. These alterations of chromatin control gene transcription. The histone acetylation status is regulated by the equilibrium of histone acet...

journal_title：Anticancer research

authors： Dressel U,Renkawitz R,Baniahmad A

更新日期：2000-03-01 00:00:00

abstract：:The authors report their experience in the radioimmunodetection of recurrent colorectal cancer in comparison with traditional examinations. 485 patients were studied after radical surgery for colorectal cancer: 168 (Group 1) were studied with a radioimmunoassisted follow-up plan including: Immunoscintigraphy (IS), ser...

journal_title：Anticancer research

authors： Prati U,Roveda L,Cantoni A,Saponaro R,Bosi F,Sandolo R,Zonta A

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND/AIM:Many studies have shown an antiproliferative, anti-inflammatory, anti-angiogenetic, and apoptosis-inducing effect of Vitamin D. A vitamin D deficiency has been associated with an increased risk for different types of cancer. This study examined vitamin D 25(OH)D levels in gynaecological cancers in compar...

journal_title：Anticancer research

authors： Kolnsberg L,Riffelmann M,Friedrich M

更新日期：2020-01-01 00:00:00

abstract：AIM:The aim of this study was to investigate if Linomide affects growth and spread of a rat liver tumour when given alone and in combination with interstitial laser thermotherapy (ILT). MATERIALS AND METHODS:Experiments were performed in Wistar rats using a dimethyl-hydrazine-induced adenocarcinoma implanted into the ...

journal_title：Anticancer research

authors： Ivarsson K,Sturesson C,Stenram U,Tranberg KG

更新日期：2003-03-01 00:00:00

abstract：:The effect of ionic strength on aclarubicin - DNA complexes was studied in comparison with its effect on daunorubicin - or doxorubicin - DNA complexes, using the spectrophotometric method. The hypochromic shift of aclarubicin, induced by its binding to native DNA, decreased to a lesser extent by the addition of Na+ th...

journal_title：Anticancer research

authors： Ando S,Kamiya K,Yoshimura T,Tsutani H,Ueda T,Uchida M,Nakamura T,Uchino H

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND/AIM:Long interspersed nuclear element-1 (LINE-1) methylation status is a marker for global DNA methylation. However, the relationship between LINE-1 methylation and the biology of lung adenocarcinoma remains unclear. Here, we aimed to examine the role of LINE-1 in lung cancer. MATERIALS AND METHODS:LINE-1 m...

journal_title：Anticancer research

authors： Kitahara H,Okamoto T,Shimamatsu S,Kohno M,Morodomi Y,Tagawa T,Kitao H,Okano S,Oda Y,Maehara Y,Mori M

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND/AIM:Patient-derived orthotopic xenograft (PDOX) models have patient-like clinical features and may be imaged, in case of some cancers, by passaging of the tumors through transgenic nude mice expressing red-fluorescent protein (RFP) where they stably acquire RFP expressing stroma. The aim of the present study...

journal_title：Anticancer research

authors： Park JH,Zhao M,Oshiro H,Miyake K,Higuchi T,Reynoso J,Razmjooei S,Bouvet M,Clary B,Zhang Z,Sugisawa N,Yamamoto J,Singh SR,Hoffman RM

更新日期：2019-07-01 00:00:00

abstract：:Eosinophil granulocytes have been implicated in anticancer immunity but recent data indicate that eosinophils can also promote cancer. Herein, we studied eosinophils in skin lesions from 43 patients with mycosis fungoides (MF). The presence of eosinophils correlated with disease stage: 78% of patients with advanced di...

journal_title：Anticancer research

authors： Fredholm S,Gjerdrum LM,Willerslev-Olsen A,Petersen DL,Nielsen IØ,Kauczok CS,Wobser M,Ralfkiaer U,Bonefeld CM,Wasik MA,Krejsgaard T,Geisler C,Ralfkiaer E,Gniadecki R,Woetmann A,Odum N

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND/AIM:To evaluate the effectiveness of enzalutamide in Italian patients with hormone-refractory metastatic castration-resistant prostate cancer, progressing after chemotherapy with docetaxel plus prednisone. PATIENTS AND METHODS:A total of 60 patients were enrolled. Reduction in serum prostate-specific antige...

journal_title：Anticancer research

authors： Cicero G,DE Luca R,Dorangricchia P,Dieli F

更新日期：2017-03-01 00:00:00

abstract：:Various lignified materials, including pine cone extract and a commercial lignin, stimulated the morphological change (spreading) of mouse peritoneal macrophages, and their functional maturation as judged by increase in NBT-reducing activity. When these materials were treated with NaClO2 to decompose the phenolic stru...

journal_title：Anticancer research

authors： Kikuchi K,Sakagami H,Fujinaga S,Kawazoe Y,Oh-Hara T,Ichikawa S,Kurakata Y,Takeda M,Sato T

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors are uncommon intra-abdominal tumors. In fewer than 5% of cases, they originate primarily from the mesentery, omentum or peritoneum and these extra-gastrointestinal stromal tumors tend to have characteristics similar to gastrointestinal stromal. CASE REPORT:We report a case of...

journal_title：Anticancer research

authors： Rediti M,Pellegrini E,Molinara E,Cerullo C,Fonte C,Lunghi A,Iori A,Neri B

更新日期：2014-02-01 00:00:00

abstract：:The incidence of female breast cancer was studied as a function of age in 71 different populations throughout the world. Incidence data was normalized for differences in frequency of occurrence. Median normalized incidence increased exponentially from age 20 to 45. After age 45 the rate of incidence decreased, and we ...

journal_title：Anticancer research

authors： Dix D,Cohen P

更新日期：1982-01-01 00:00:00

abstract：:A better understanding of the non-targeted (bystander) effects of radiation may have important implications with regards to radiation risk assessment, radiation protection, and targeted cancer therapy. In the present study, the direct and bystander effects of α-particle irradiation in immortalized human fibroblasts (F...

journal_title：Anticancer research

authors： Dahle J,Kalanxhi E,Tisnek N

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Sonic hedgehog (SHH) signaling is related to the pathogenesis of oral squamous cell carcinoma (OSCC), but its role in OSCC is not yet well understood. In this study, we analyzed the role of SHH signaling in OSCC. MATERIALS AND METHODS:We examined the expression pattern of SHH and its signal proteins in clin...

journal_title：Anticancer research

authors： Kuroda H,Kurio N,Shimo T,Matsumoto K,Masui M,Takabatake K,Okui T,Ibaragi S,Kunisada Y,Obata K,Yoshioka N,Kishimoto K,Nagatsuka H,Sasaki A

更新日期：2017-12-01 00:00:00

abstract：:The pharmacokinetics of platinum in cancer patients were examined following an intravenous infusion of cis-diammine(glycolato) platinum, 254-S. The plasma concentrations of total platinum, which decreased biexponentially after the infusion, were proportional to the dose over the range of 10 to 120 mg/m2, suggesting li...

journal_title：Anticancer research

authors： Ota K,Oguma T,Shimamura K

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND/AIM:Small cell lung cancer (SCLC) is still a deadly type of cancer for which there are few effective therapeutic strategies. Development of a new molecule targeting agent is urgently desired. Previously we showed that recombination signal binding protein for immunoglobulin-kappa-J region (RBPJ) and mastermin...

journal_title：Anticancer research

authors： Onishi H,Ichimiya S,Yanai K,Umebayashi M,Nakamura K,Yamasaki A,Imaizumi A,Nagai S,Murahashi M,Ogata H,Morisaki T

更新日期：2018-08-01 00:00:00

abstract：:Three histamine H2-receptor antagonists, Cimetidine, Metiamide and Ranitidine, were tested for their inhibitory effect on two experimental bowel cancer models. In the first model mitotic rates were measured in dimethylhydrazine-induced tumors of rat colon and in the second model volumetric changes in human large bowel...

journal_title：Anticancer research

authors： Tutton PJ,Barkla DH

更新日期：1983-01-01 00:00:00

abstract：:We studied a consecutive series of 54 cases of lower lip squamous cell carcinoma (LLSCC) in order to identify any variables which might predict the development of lymph node metastases. The cases were divided into 38 tumors without metastases (group I) and 16 tumors with lymph node metastases (group II). The following...

journal_title：Anticancer research

authors： Rodolico V,Daniele E,Leonardi V,Marra G,Luciani A,Settineri G,Tralongo V

更新日期：1998-03-01 00:00:00

abstract：:The effects of dibutyryl cyclic AMP (DBcAMP) on tissue inhibitor metalloproteinase (TIMP) expression were studied in the human hepatoma cell line PLC/PRF/5 with relation to the invasive activity of the cells. Messenger RNA expression levels of metalloproteinases (MMP)-2 and 9, and TIMP-1, 2 and 3 in the cells were det...

journal_title：Anticancer research

authors： Okamoto Y,Nakano H

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND/AIM:Invasive bladder cancer mortality remains high despite progresses made in early diagnosis and surgical procedures. Thus, there is a need to define new markers for bladder cancer. CLIC1 has not been previously studied in bladder cancer and thus, we aimed to assess its immunohistochemical expression in rel...

journal_title：Anticancer research

authors： Adelmann TG,Camerota TC,Ceausu AR,Cimpean AM,Mazzanti M,Raica M

更新日期：2020-12-01 00:00:00

abstract：:Megakaryocyte polyploidization responds to platelet demand and results from the lack of cytoplasmic separation while the nucleus keeps dividing. In normal telophase, the plane of the actin constriction ring is determined by the tubulin spindle. In order to investigate the role of tubulin in the megakaryocyte polyploid...

journal_title：Anticancer research

authors： Baatout S,Chatelain B,Staquet P,Symann M,Chatelain C

更新日期：1998-05-01 00:00:00

abstract：:The relationship between production of Colony-Stimulating Factor (CSF) and metastasis has been investigated in the TS/A murine model. CSF production was determined in TS/A cell variants isolated through serial in vivo selection of lung metastatic nodules induced by intravenous or subcutaneous injection of tumor cells ...

journal_title：Anticancer research

authors： Nicoletti G,Lollini PL,Bagnara GP,De Giovanni C,Del Re B,Bons L,Prodi G,Nanni P

更新日期：1987-07-01 00:00:00

abstract：:An MCF-7 human breast cancer line variant (MCF-7/MPA), resistant to medroxyprogesterone-acetate (MPA), was obtained by continuous exposure in vitro to the drug. MCF-7/MPA cells were grown in the presence of 12.5 x 10(-6) M MPA and were selected by increasing the concentration of the drug in the growth medium in a step...

journal_title：Anticancer research

authors： Gibelli N,Zibera C,Sica G,Carbone M,Pedrazzoli P,Robustelli della Cuna G

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the clinical feasibility and surgical outcomes of robotic-assisted transperitoneal infrarenal para-aortic lymphadenectomy (TIPAL) in patients with gynecological malignancies. PATIENTS AND METHODS:The perioperative outcomes in 90 patients with gynecological malignancies who underwent laparos...

journal_title：Anticancer research

authors： Lee HJ,Lee YH,Chong GO,Hong DG,Lee YS

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Most cancer cells exhibit increased anaerobic glycolysis and use this metabolic pathway for the generation of ATP as a main source of energy. This impaired metabolism of glucose, leading to the secretion of lactic acid even in the presence of oxygen, is named the Warburg effect. Because cancer cells are part...

journal_title：Anticancer research

authors： Zhang X,Varin E,Briand M,Allouche S,Heutte N,Schwartz L,Poulain L,Icard P

更新日期：2009-04-01 00:00:00

abstract：:Estrogen receptor activation in hormone dependent cells (MCF-7 and T47D) and hormone independent cells (MDA-MB-231) was measured by bioluminescence in stably transfected human breast cancer MCF-7, T47D and MDA-MB-231 cell lines with a reporter gene which allows expression of the firefly luciferase enzyme under the con...

journal_title：Anticancer research

authors： Le Bail JC,Allen K,Nicolas JC,Habrioux G

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:5-Fluorouracil (5-FU) and cisplatin combined chemotherapy (FP) is commonly used for esophageal cancer. Acquired resistance needs to be overcome to improve the chemotherapeutic effect. MATERIALS AND METHODS:The FP-resistant xenograft model using severe combined immunodeficient (SCID) mice was established as ...

journal_title：Anticancer research

authors： Yoshida T,Miyoshi T,Seike J,Yamai H,Takechi H,Yuasa Y,Tangoku A

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the expression of thymidine phosphorylase (TP), a known angiogenic factor for endothelial cells, in gastric carcinoma cells and tumor-associated stromal cells. MATERIALS AND METHODS:Sixty-six gastric carcinomas were studied. TP expression was assessed with the P-GF.4...

journal_title：Anticancer research

authors： Liakakos T,Troupis T,Ghiconti I,Triantafyllidis S,Macheras A,Karatzas G,Pavlakis K

更新日期：2006-09-01 00:00:00