Abstract：
BACKGROUND/AIM:4-methylumbelliferone (4-MU) has received considerable attention due to its potential for cancer treatment since it inhibits cell proliferation, migration and invasion. An increasing body of evidence suggests that extracellular matrix (e.g. hyaluronan) and nutrients (e.g. glucose) in the tumor microenvironment may affect cellular responses to extracellular signals. This study investigates the role of hyaluronan and glucose on 4-MU-inhibited cell proliferation in breast carcinoma cells. MATERIALS AND METHODS:4-MU-inhibited cell proliferation was determined using the soluble formazan dye, whose absorbance is directly proportional to the number of living cells, under conditions of competent vs. deficient in producing hyaluronan, or low vs. high glucose in culture media of breast carcinoma cells. RESULTS:Cellular sensitivity to 4-MU-inhibited cell proliferation was altered by changes in the amount of hyaluronan or glucose in the tumor microenvironment. CONCLUSION:Increased amounts of hyaluronan or glucose in the tumor microenvironment reduced cellular sensitivity of breast carcinoma cells to 4-MU-inhibited cell proliferation.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Wang R,Zhou W,Wang J,Liu Y,Chen Y,Jiang S,Luo X,Stupack DG,Luo Nsubject
Has Abstractpub_date
2015-09-01 00:00:00pages
4799-805issue
9eissn
0250-7005issn
1791-7530pii
35/9/4799journal_volume
35pub_type
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journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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更新日期：2016-01-01 00:00:00
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journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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