Abstract：
BACKGROUND:The prognosis for advanced gastric cancer with paraaortic lymph node (PALN) metastasis is very poor even after a curative resection. In the present study, induction chemotherapy followed by curative surgery was performed for advanced gastric cancer with PALN metastasis. PATIENTS AND METHODS:Twenty patients with no non-curative factors except PALN metastasis who showed good clinical response for induction chemotherapy were enrolled in the study. RESULTS:Combined S-1 plus cisplatin chemotherapy was administered to 10 patients; docetaxel, 5-FU plus cisplatin, to 5; S-1 plus paclitaxel to 3; and capecitabine plus cisplatin, to 2 patients. The overall response rate was 80% (16 out of 20 patients responded). All patients underwent curative gastrectomy with extended lymphadenectomy including the PALNs. Out of the 20 patients, 8 survived more than 5 years, and the 3- and 5-year survival rates were 72% and 65%, respectively. Female gender and residual PALN metastasis were significantly associated with worse prognosis and patients with a diffuse-type histology had a tendency to worse prognosis. CONCLUSION:Induction chemotherapy followed by curative surgery including extended PALN dissection seems a promising strategy for advanced gastric cancer with PALN metastasis as a sole distant metastasis, particularly for male patients and those with intestinal-type histology.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Fujiwara Y,Omori T,Demura K,Miyata H,Sugimura K,Ohue M,Kobayashi S,Takahashi H,Doki Y,Yano Msubject
Has Abstractpub_date
2015-12-01 00:00:00pages
6739-45issue
12eissn
0250-7005issn
1791-7530pii
35/12/6739journal_volume
35pub_type
杂志文章abstract：BACKGROUND/AIM:Intensity-modulated radiation therapy (IMRT) is a form of radiation therapy that allows accurate irradiation with reduced damage to surrounding tissues. Here, we analyzed borderline-resectable pancreatic cancer (BRPC) with arterial abutment (BR-A) patients with IMRT as neoadjuvant therapy and performed c...
journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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doi：
更新日期：2002-05-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
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doi：
更新日期：2009-07-01 00:00:00
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doi：
更新日期：1993-11-01 00:00:00
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doi：
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doi：
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更新日期：2013-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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