Effect of breast cancer adjuvant therapies on potential biomarkers of pulmonary inflammation.

Abstract:

BACKGROUND:The aim of this study was to investigate the effect of breast cancer adjuvant therapies on the levels of circulating surfactant protein-D (SP-D), C-Reactive protein (CRP) and soluble receptor for advanced glycation end-products (sRAGE), as potential biomarkers of subclinical pulmonary inflammation. MATERIALS AND METHODS:The soluble molecules were serially determined in 38 patients, prior to the initiation of radiation therapy (RT) and during adjuvant treatment, using immunoassays. RESULTS:Significantly higher levels of all three biomarkers were observed in patients prior to the initiation of RT compared to healthy controls (CRP: p<0.001, SP-D: p<0.05, sRAGE: p<0.05). SP-D levels exhibited a gradual increase after RT and during follow-up (p<0.005). Patients treated with a combination of RT and hormonal therapy presented a significant, but less pronounced, increase in SP-D and a significant decrease in CRP compared to those who did not receive hormonal therapy (p=0.0428 and p=0.0116, respectively). Patients treated with a combination of RT and trastuzumab presented a significant increase in SP-D levels (p=0.0310). CONCLUSION:The average rate of change in the levels of circulating SP-D and CRP during postoperative irradiation and adjuvant hormonal therapy suggests that the combined therapeutic regiment may potentially exert important anti-inflammatory effects on the lung. On the contrary, combined administration of RT and trastuzumab is likely to induce or provoke pulmonary inflammation.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Piperis M,Provatopoulou X,Sagkriotis A,Kalogera E,Ampatzoglou E,Zografos GC,Athanasiou E,Gounaris A

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

4993-5002

issue

11

eissn

0250-7005

issn

1791-7530

pii

32/11/4993

journal_volume

32

pub_type

杂志文章
  • Induction of cell death by pro-oxidant action of Moxa smoke.

    abstract::Moxa smoke induced internucleosomal DNA fragmentation in human promyelocytic leukemic HL-60 cells, but not in other cell lines. The cytotoxic activity of Moxa smoke was significantly reduced by a popular antioxidant, N-acetyl-L-cysteine (NAC). Moxa smoke showed oxidation potential (measured by NO monitor) and produced...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Hitosugi N,Ohno R,Hatsukari I,Nakamura S,Mizukami S,Nagasaka H,Matsumoto I,Satoh K,Negoro T,Hashimoto K,Sakagami H

    更新日期:2002-01-01 00:00:00

  • Methylglyoxal bis (cyclopentylamidinohydrazone) (MGBCP): antitumor effect against human osteosarcoma cells and combined effect with methotrexate, adriamycin and 4-hydroperoxyifosfamide.

    abstract::The antitumor effect of a polyamine biosynthetic pathway inhibitor methylglyoxal bis(cyclopentylamidinohydrazone) (MGBCP) on human osteosarcoma cell lines such as KHOS-240S, MG-63 and G-292 cells, and its effect in combination with anticancer drugs such as methotrexate (MTX), adriamycin (ADM) and 4-hydroperoxyfosfamid...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Sonoda J,Hibasami H,Yamada H,Fujinami S,Nakashima K,Ogihara Y

    更新日期:1995-05-01 00:00:00

  • The protective effect of hochu-ekki-to (TJ-41), a Japanese herbal medicine, against HSV-1 infection in mitomycin C-treated mice.

    abstract:BACKGROUND:Immmunosuppression and infectious disease in cancer patients receiving chemotherapy is a serious problem. Immunopotentiating drugs may show a therapeutic efficacy. MATERIALS AND METHODS:The protective effect of Hochu-ekki-to (TJ-41), a Japanese traditional herbal medicine, on mitomycin C (MMC)-induced immun...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kido T,Mori K,Daikuhara H,Tsuchiya H,Ishige A,Sasaki H

    更新日期:2000-11-01 00:00:00

  • Proteomic analysis showed down-regulation of nucleophosmin in progressive tumor cells compared to regressive tumor cells.

    abstract::Important strategies against cancer are based on the understanding of the mechanisms of tumor progression. To elucidate alterations regarding tumor progression, we have performed proteomic differential display analysis for the expression of intracellular proteins in the regressive murine fibrosarcoma cell clone QR-32 ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Takenawa T,Kuramitsu Y,Wang Y,Okada F,Tokuda K,Kitagawa T,Ueyama Y,Nakamura K

    更新日期:2013-01-01 00:00:00

  • Efficacy of the progesterone receptor antagonist mifepristone for palliative therapy of patients with a variety of advanced cancer types.

    abstract:BACKGROUND:Mifepristone has been demonstrated to improve longevity and quality of life in mice with spontaneous murine cancer without progesterone receptors and in human colon cancer. The present study evaluated the palliative effect of mifepristone in a variety of different types of human cancer. PATIENTS AND METHODS...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Check JH,Dix E,Cohen R,Check D,Wilson C

    更新日期:2010-02-01 00:00:00

  • Recorded quadrant incidence of female breast cancer in Great Britain suggests a disproportionate increase in the upper outer quadrant of the breast.

    abstract:BACKGROUND:The upper outer quadrant (UOQ) of the breast is the most frequent site for incidence of breast cancer, but the reported disproportionate incidence in this quadrant appears to rise with year of publication. MATERIALS AND METHODS:In order to determine whether this increasing incidence in the UOQ is an artifac...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Darbre PD

    更新日期:2005-05-01 00:00:00

  • MicroRNA Expression in KRAS- and BRAF-mutated Colorectal Cancers.

    abstract:BACKGROUND/AIM:KRAS and BRAF are two genes commonly mutated in colorectal cancer (CRC). Even though BRAF is a downstream target of KRAS in the MAPK signalling pathway, KRAS- and BRAF-mutated CRCs are found to display several different clinical and histopathological features. We investigated whether a differential expre...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12272

    authors: Lundberg IV,Wikberg ML,Ljuslinder I,Li X,Myte R,Zingmark C,Löfgren-Burström A,Edin S,Palmqvist R

    更新日期:2018-02-01 00:00:00

  • Lysozyme is up-regulated in columnar-lined Barrett's mucosa: a possible natural defence mechanism against Barrett's esophagus-associated pathogenic bacteria.

    abstract:BACKGROUND:Lysozyme is a natural antimicrobial enzyme that is up-regulated in inflammatory diseases of the gastrointestinal tract. Pathogenic microbes have recently been identified in the esophageal mucosa in patients with Barrett's esophagus (BE). Lysozyme expression was evaluated in biopsies from patients with BE. M...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Rubio CA

    更新日期:2012-11-01 00:00:00

  • Invading basal cell carcinoma of the jaw: an under-evaluated complex entity.

    abstract::Basal cell carcinoma (BCC) is a locally invasive neoplasm, rarely metastatic, yet capable of significant local destruction and disfigurement. Invasion into the bone is uncommon and only a few cases of invasion into facial bones, but never to the mandible or maxilla, have been described. We report three patients with B...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Nagler RM,Laufer D

    更新日期:2001-01-01 00:00:00

  • Anti-estrogenic activities of indole-3-carbinol in cervical cells: implication for prevention of cervical cancer.

    abstract:BACKGROUND:Cervical cancer constitutes the second most common cancer in women. Estrogen promotes development of cervical cancer in cells infected with high risk human papillomaviruses (HPVs). We asked whether the phytochemical indole-3-carbinol (I3C) has anti-estrogenic activities in cervical cells with the goal of pre...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Yuan F,Chen DZ,Liu K,Sepkovic DW,Bradlow HL,Auborn K

    更新日期:1999-05-01 00:00:00

  • Reversal of multidrug resistance of cancer cells in vitro: modification of drug resistance by selected carotenoids.

    abstract::The development of multidrug resistance (MDR) causes difficulties in the chemotherapy of of human cancer. Investigation of the possibility of reversal of MDR has been greatly aided by the use of cell lines with acquired resitance to anticancer agents in vitro or transfected with the mdrl gene. The aim of this study wa...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Gyémánt N,Tanaka M,Molnár P,Deli J,Mándoky L,Molnár J

    更新日期:2006-01-01 00:00:00

  • MicroRNAs Associated With Biological Pathways of Left- and Right-sided Colorectal Cancer.

    abstract:BACKGROUND/AIM:MicroRNAs (miRNAs) regulate the development of colorectal cancer (CRC). We aimed to investigate miRNAs and their relation to cancer-related signaling pathways in site-specific CRC. MATERIALS AND METHODS:We used a total of 24 left- and right-sided Finnish CRC samples (discovery cohort) and The Cancer Gen...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.14360

    authors: Eneh S,Heikkinen S,Hartikainen JM,Kuopio T,Mecklin JP,Kosma VM,Mannermaa A

    更新日期:2020-07-01 00:00:00

  • Comparative anti-inflammatory activities of curcumin and tetrahydrocurcumin based on the phenolic O-H bond dissociation enthalpy, ionization potential and quantum chemical descriptor.

    abstract::Curcumin and its reduced derivative tetrahydrocurcumin have been shown to exhibit chemopreventive activity. Cyclooxygenase-2 (COX-2) inhibition in lipopolysaccharide (LPS)- or Porphyromonas gingivalis fimbria-stimulated RAW 264.7 cells was investigated using Northern blot analysis. The fimbria-stimulated expression of...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Murakami Y,Ishii H,Takada N,Tanaka S,Machino M,Ito S,Fujisawa S

    更新日期:2008-03-01 00:00:00

  • Induction of apoptosis by 1,4-phenylenebis(methylene)selenocyanate in cultured human colon cancer cells.

    abstract::Using a cultured human colon cancer cell line (Col 2), a structurally diverse group of chemopreventive agents was evaluated for their potential to induce apoptosis. As a result, 1,4-phenylenebis(methylene)selenocyanate (p-xylylselenocyanate; p-XSC) was found to be active in this process. p-XSC, a synthetic organoselen...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Lee SK,Heo YH,Steele VE,Pezzuto JM

    更新日期:2002-01-01 00:00:00

  • p53 mutations in colorectal cancers in the patients of Metropolitan New York.

    abstract::An unselected series of 19 colorectal adenocarcinomas obtained from patients treated by surgery at Memorial Sloan-Kettering Cancer Center (MSKCC), New York, USA was investigated for mutations in exons 5, 6, 7 and 8 of the p53 gene. Ten of the tumors revealed at least one somatic mutation either in the exon 5 or 8. Two...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: van den Broek MH,Jhanwar SC,Fodde R,Chaganti RS,Meera Khan PM

    更新日期:1993-09-01 00:00:00

  • Geographical Differences in Likelihood of Home Death Among Palliative Cancer Patients: A National Population-based Register Study.

    abstract:BACKGROUND/AIM:Previous studies have shown discrepancies between patient's desired and actual death place. As planning of family support and involvement of palliative home care teams seem to improve the chance to meet patients preferences, geographical availability of specialized palliative home care could influence pl...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.14380

    authors: Nilsson J,Axelsson B,Holgersson G,Carlsson T,Bergqvist M,Bergstrom S

    更新日期:2020-07-01 00:00:00

  • Biological evaluation of 2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinone as an anti-breast cancer agent.

    abstract:BACKGROUND:Breast cancer is the most frequent cancer and the second leading cause of cancer deaths in women today. A number of 1,4-naphthoquinone derivatives have been found to possess significant pharmacological effects associated with marked antimicrobial and antitumor activities. In the present study, the in vitro e...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kanaan YM,Das JR,Bakare O,Enwerem NM,Berhe S,Beyene D,Williams V,Zhou Y,Copeland RL Jr

    更新日期:2009-01-01 00:00:00

  • Predicting response to therapy of squamous cell carcinoma of the head and neck (review).

    abstract::The design of treatment for patients with squamous cell carcinoma of the head and neck (SCCHN) is based on prognostic factors, today essentially performance status and TNM status. It becomes increasingly important to optimise treatment and find the appropriate level of treatment and resource consumption for each patie...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Wennerberg J

    更新日期:1996-07-01 00:00:00

  • Prognostic significance of T helper 1 and 2 and T cytotoxic 1 and 2 cells in patients with non-small cell lung cancer.

    abstract:BACKGROUND:We report the prognostic significance of peripheral and tumor-infiltrating Th1, Th2, Tc1 and Tc2 cells in lung cancer patients. MATERIALS AND METHODS:We evaluated the rates of interferon (IFN)-gamma+/CD4+ cells (Th1), interleukin (IL)-4+ /CD4+ cells (Th2), IFN-gamma+/CD8+ cells (Tc1), IL-4+ /CD8+ cells (Tc2...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Ito N,Suzuki Y,Taniguchi Y,Ishiguro K,Nakamura H,Ohgi S

    更新日期:2005-05-01 00:00:00

  • R-verapamil decreases anti-estrogen resistance in a breast cancer model.

    abstract::Drug resistance eventually limits the effectiveness of antiestrogens in breast cancer treatment. Pharmacological reversal of this refractoriness has been attempted with R-Verapamil, a well tolerated calcium channel blocker. This drug significantly decreased the incidence of lung foci after intravenous seeding of the R...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kellen JA,Wong A,Georges E,Ling V

    更新日期:1991-03-01 00:00:00

  • A quantitative study of radiation-induced apoptosis in two rat yolk sac tumour cell lines with different radiosensitivities in vitro.

    abstract::Two rat yolk sac tumour cell lines with different radiosensitivities were used to quantify the extent of apoptosis following irradiation by using a DNA fragmentation assay in vitro. Apoptosis was also confirmed by fluorescence analysis of nuclear morphological changes by using Hoechst 33258. A radiosensitive cell line...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Mitsuhashi N,Ishikawa H,Saito Y,Takahashi T,Sakurai H,Nozaki M,Akimoto T,Hasegawa M,Maebayashi K,Niibe H

    更新日期:1997-09-01 00:00:00

  • Long-term follow-up for patients with papillary thyroid carcinoma treated as benign nodules.

    abstract:BACKGROUND:The recent prevalence of ultrasonography and fine-needle aspiration biopsy (FNAB) has facilitated the detection and diagnosis of papillary thyroid carcinoma. However, there are still cases that are preoperatively misdiagnosed and treated as benign nodules because ultrasonographic and FNAB findings do not pro...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Ito Y,Higashiyama T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

    更新日期:2007-03-01 00:00:00

  • Terminal differentiation of human leukemic blasts in response to 12-0-tetradecanoyl-13-phorbol acetate (TPA).

    abstract::Phorbol ester, 12-0-Tetradecanoyl-13-Phorbol-Acetate (TPA), induces a terminal macrophage-like differentiation of cells from human acute myelogenous leukemia cell lines. We report here that blastoid cells obtained from acute nonlymphocytic leukemia (M1-M2) undergo differentiation-related changes characteristic of macr...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Joshi KS,Rao SG,Joshi DS,Advani SH,Bhisey AN

    更新日期:1988-11-01 00:00:00

  • Intermediate stage Hodgkin's disease: preliminary results on 210 patients treated with four ABVD chemotherapy cycles plus extended versus involved field radiotherapy.

    abstract:BACKGROUND:To improve long-term survival by reducing toxicity in intermediate stage Hodgkin's disease patients, we compared the effects of involved field (IF) versus extended field (EF) irradiation administered after four cycles of ABVD regimen. MATERIALS AND METHODS:Two hundred and ten Hodgkin's disease patients, at ...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Anselmo AP,Cavalieri E,Osti FM,Cantonetti M,De Sanctis V,Alfo M,Amadori S,Enrici RM

    更新日期:2004-11-01 00:00:00

  • Level of Melanotransferrin in Tissue and Sera Serves as a Prognostic Marker of Gastric Cancer.

    abstract:AIM:The aim of the study was to identify novel biomarkers that are vital for improving management of patients with gastric cancer (GC). MATERIALS AND METHODS:An RNA-sequencing analysis was conducted using gastric tissue from patients with metastatic GC. In vitro cell functions were evaluated by siRNA-mediated knockdow...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.13820

    authors: Sawaki K,Kanda M,Umeda S,Miwa T,Tanaka C,Kobayashi D,Hayashi M,Yamada S,Nakayama G,Omae K,Koike M,Kodera Y

    更新日期:2019-11-01 00:00:00

  • A Prospective Study of Intensity-modified Radiation Therapy in Comparison with Conventional 3D-RT for BR Pancreatic Cancer Patients with Arterial Involvement.

    abstract:BACKGROUND/AIM:Intensity-modulated radiation therapy (IMRT) is a form of radiation therapy that allows accurate irradiation with reduced damage to surrounding tissues. Here, we analyzed borderline-resectable pancreatic cancer (BRPC) with arterial abutment (BR-A) patients with IMRT as neoadjuvant therapy and performed c...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12172

    authors: Masui T,Takaori K,Anazawa T,Sato A,Nakano K,Uchida Y,Yogo A,Goto Y,Matsumoto S,Kodama Y,Kanai M,Isoda H,Mizumoto M,Kawaguchi Y,Shibuya K,Itasaka S,Uemoto S

    更新日期:2017-12-01 00:00:00

  • Complete pathological response in advanced extra-gastrointestinal stromal tumor after imatinib mesylate therapy: a case report.

    abstract:BACKGROUND:Gastrointestinal stromal tumors are uncommon intra-abdominal tumors. In fewer than 5% of cases, they originate primarily from the mesentery, omentum or peritoneum and these extra-gastrointestinal stromal tumors tend to have characteristics similar to gastrointestinal stromal. CASE REPORT:We report a case of...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Rediti M,Pellegrini E,Molinara E,Cerullo C,Fonte C,Lunghi A,Iori A,Neri B

    更新日期:2014-02-01 00:00:00

  • Clinical significance of angiogenesis, proliferation and apoptosis in renal cell carcinoma.

    abstract:BACKGROUND:The prognostic significance of angiogenesis, proliferation and apoptosis after interferon (IFN) was investigated in 96 patients with renal cell carcinoma (RCC). MATERIALS AND METHODS:Microvessel density in the tumor(MVD), proliferative index(PI) and apoptotic index(AI) were quantified using immunohistochemi...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Yoshino S,Kato M,Okada K

    更新日期:2000-01-01 00:00:00

  • Influence of tamoxifen on the tumor content of steroid hormone receptors (ER, PgR and AR) in patients with primary breast cancer.

    abstract::A possible influence of tamoxifen (TAM) treatment on the measurable content of some steroid hormone receptors (i.e. ER, PgR, AR) from primary breast cancers has been evaluated. In eleven postmenopausal women, two biopsies were taken from the same tumor, the first biopsy before starting endocrine treatment, and a secon...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Lundgren S,Søreide JA,Lea OA

    更新日期:1994-05-01 00:00:00

  • D.N.C.B. for malignant melanoma: significance in the treatment strategy.

    abstract::2-4 Dinitrochlorobenzene (D.N.C.B.) is a synthetic primary allergenic molecule which has proved to have at least two useful clinical applications as regards neoplastic conditions. As a diagnostic measure, it serves in the detection of global alterations of cellular immunity. As a therapeutical measure, its epicutaneou...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Truchetet F,Heid E,Friedel J,Chartier C,Grosshans E

    更新日期:1989-11-01 00:00:00