Prophylactic Radiotherapy to Intervention Sites in Malignant Pleural Mesothelioma--Single-institution Experience and Literature Review.

Abstract:

AIM:To evaluate the efficacy of prophylactic radiotherapy at intervention sites in patients with malignant pleural mesothelioma (MPM). PATIENTS AND METHODS:From 05/2010 to 12/2014, 53 patients with histologically confirmed MPM were treated in order to prevent interventional site metastases. Irradiation was carried out with 3 × 7=21 Gy with 6-18 MeV electrons. RESULTS:The mean follow-up period was 14.4 months (range=0-37 months). At the time of the analysis, 20 patients were alive. Three patients had developed a local recurrence within the irradiated site, representing a local recurrence rate of 5.7%. Toxicity was low, with transient grade I erythema found in 20.7% of patients. No grade II or higher toxicity was observed. CONCLUSION:Our simple and time-saving RT approach to interventional sites in patients with MPM was both effective and well-tolerated. This approach is easily integrated into general treatment concepts. Until publication of results from prospective randomized trials, prophylactic RT to intervention sites should remain standard.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Janssen S,Schönhofer B,Rades D

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

4151-4

issue

7

eissn

0250-7005

issn

1791-7530

pii

35/7/4151

journal_volume

35

pub_type

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