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Molecular Characterization of Second Primary Endometrial Cancer.

Abstract：

BACKGROUND/AIM:The objective of this study was to determine the molecular and clinicopathological features, as well as the prognosis of patients with endometrial cancer (EC) having prior malignancy (second primary EC: SPEC) compared with those without a history of prior malignancy (first primary EC: FPEC). MATERIALS AND METHODS:We enrolled 294 FPEC patients and 32 SPEC patients who had undergone surgical resection with curative intent. EC was divided into four groups according to Cancer Genome Atlas Research Network (TCGA) classification. RESULTS:SPEC patients having greater than a 10-year interval from prior malignancy had risk factors including type II histology, deeper myometrial invasion, cervical invasion, and copy number high (CNH) phenotype compared with patients having less than a 10-year interval (p=0.007, p=0.002, p=0.015 and p=0.001). CONCLUSION:SPEC patients having greater than a 10-year interval from prior malignancy possessed numerous high-risk factors for EC.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Haraga J,Nakamura K,Haruma T,Nyuya A,Nagasaka T,Masuyama H

doi

10.21873/anticanres.14370

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

3811-3818

issue

7

eissn

0250-7005

issn

1791-7530

pii

40/7/3811

journal_volume

40

pub_type

杂志文章

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