Abstract：
BACKGROUND/AIM:Curcumin is a promising nutraceutical for chemoprevention of head and neck squamous cell carcinoma (HNSCC). Capsular formulations of curcumin demonstrate low systemic bioavailability. We aimed to determine if curcumin levels were higher in healthy volunteers and cancer patients with microgranular curcumin that allows for transmucosal absorption and identify a consistent biomarker. PATIENTS AND METHODS:Eight healthy volunteers and 15 HNSCC patients completed the trials. Serum levels of curcumin were measured by HPLC. Biological activity of curcumin was assessed with Multiplex Immunoassay and immunohistochemistry. RESULTS:We achieved higher serum levels of curcumin compared to trials using capsular formulation. In cancer patients a significant decrease in expression of fibroblast growth factor-2 (FGF-2) in post-biopsy samples and decreased serum levels of FGF-2, granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-17 (IL-17) (p<0.05) was observed. CONCLUSION:Transmucosal administration of microgranular curcumin leads to enhanced curcumin bioavailability that is associated with significant biological effects.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Latimer B,Ekshyyan O,Nathan N,Moore-Medlin T,Rong X,Ma X,Khandelwal A,Christy HT,Abreo F,McClure G,Vanchiere JA,Caldito G,Dugas T,McMartin K,Lian T,Mehta V,Nathan CAsubject
Has Abstractpub_date
2015-12-01 00:00:00pages
6411-8issue
12eissn
0250-7005issn
1791-7530pii
35/12/6411journal_volume
35pub_type
杂志文章abstract：BACKGROUND/AIM:Extracts of Paeonia suffruticosa are traditionally used in Chinese medicine to increase blood flow. Recently, this extract has been shown to possess anti-tumor and anti-inflammatory properties, though this mechanism remains unknown. In the current work, we prepared extracts of P. suffruticosa and analyze...
journal_title：Anticancer research
pub_type： 杂志文章
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2006-11-01 00:00:00
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更新日期：2018-08-01 00:00:00
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abstract：BACKGROUND/AIM:Phenolic compounds isolated from Dendrobium ellipsophyllum Tang & Wang (Orchidaceae) have been shown to possess potential pharmacological activity; however, their anticancer as well as anti-metastasis activities are largely unknown. The aim of the present study was to isolate active compounds from D. ell...
journal_title：Anticancer research
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更新日期：2014-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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abstract：BACKGROUND:The leptin receptor is involved in modulating leptin activity, acting as a carrier protein. A link between leptin or leptin receptor and cancer development has been proposed and here, the hypothesis that leptin and its receptor might be implicated in colorectal cancer (CRC) progression and invasion was inves...
journal_title：Anticancer research
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doi：
更新日期：2011-10-01 00:00:00
abstract：:The retinoblastoma suppressor (Rb)-associated protein 46 (RbAp46) is a nuclear protein of 46 kDa and contains four repeats that end with Trp-Asp (WD) residues. In this study, we reveal that the RbAp46 protein level upon SUMO-1 expression was increased. The increasing level of RbAp46 protein by SUMO-1 was not regulated...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2008-11-01 00:00:00
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journal_title：Anticancer research
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更新日期：2014-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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doi：
更新日期：2002-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,多中心研究
doi：
更新日期：2016-05-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2012-08-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：1998-11-01 00:00:00
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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doi：
更新日期：2012-03-01 00:00:00
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journal_title：Anticancer research
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doi：
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doi：
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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doi：
更新日期：2011-07-01 00:00:00
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journal_title：Anticancer research
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doi：
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doi：
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doi：
更新日期：2011-06-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2000-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1994-05-01 00:00:00
