当前位置： SCI文献检索 > ANTICANCER RESEARCH期刊下所有文献 > Correlation between COX-2 and APC expression in left versus right-sided human colon cancer.

Correlation between COX-2 and APC expression in left versus right-sided human colon cancer.

Abstract：

BACKGROUND:Because of clinicopathologic and genetic differences between left-sided colorectal cancer (LSCRC) and right-sided colon cancer (RSCC), cyclooxygenase-2(COX-2) and adenomatous polyposis coli (APC) expression may be of clinical relevance. MATERIALS AND METHODS:Clinicopathologic information for 72 primary colon tumors, 44 left and 28 right, from 72 patients (34 F, 38 M) were analyzed. COX-2 and wild-type APC (W-APC) immunohistochemical expressions were determined for each case. The data were analyzed using the Chi-square test and exact binomial confidence intervals. RESULTS:Overall, 31 out of 44 (70%) LSCRC were W-COX-2 positive vs. 13 out of 28 (46%) RSCC (p-value=0.042). When evaluated independently of the anatomic location, COX-2 expression showed a borderline statistical correlation with the lack of W-APC protein (p-value=0.054). When considering location of tumors, the inverse correlation between COX-2 and W-APC expression became statistically significant (p-value=0.024). CONCLUSION:We report a strong inverse correlation between COX-2 and W-APC expression, with COX-2 being more frequently as expressed in LSCRC. These data may be useful to stratify colorectal cancer patients into right- and left-sided and COX-2 expressor and non-expressor subsets, when evaluating COX-2 inhibitor and other targeted therapies in colon cancer.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Nasir A,Lopez A,Boulware D,Malafa M,Coppola D

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

2191-5

issue

6

eissn

0250-7005

issn

1791-7530

pii

31/6/2191

journal_volume

31

pub_type

杂志文章

相关文献

ANTICANCER RESEARCH文献大全
  • Assessment of Factors Predicting Disease Progression in Japanese Patients With Non-Metastatic Castration-resistant Prostate Cancer.

    abstract：BACKGROUND/AIM:Despite recent introduction of several novel agents, limited data exist regarding parameters that help predict the progression of non-metastatic castration-resistant prostate cancer (nmCRPC). The objective of this study was to identify prognostic predictors in nmCRPC patients. PATIENTS AND METHODS:This ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.14049

    authors： Miyake H,Watanabe K,Matsushita Y,Watanabe H,Tamura K,Motoyama D,Ito T,Sugiyama T,Otsuka A

    更新日期：2020-02-01 00:00:00

  • Induction of MMP-13 expression in bone-metastasizing cancer cells by type I collagen through integrin α1β1 and α2β1-p38 MAPK signaling.

    abstract：BACKGROUND:Breast cancer cells frequently metastasize to the skeleton and produce and secrete proteinases, such as matrix metalloproteinase-13 (MMP-13), which promote destruction of the bone matrix. However, the mechanism of MMP-13 expression induced in areas of bone metastasis is unknown. Here, the interaction between...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Ibaragi S,Shimo T,Hassan NM,Isowa S,Kurio N,Mandai H,Kodama S,Sasaki A

    更新日期：2011-04-01 00:00:00

  • Pomegranate extract induces cell cycle arrest and alters cellular phenotype of human pancreatic cancer cells.

    abstract：BACKGROUND:Pomegranate extract (PE) is a standardized whole-fruit extract of pomegranate, a fruit with known anticancer properties. MATERIALS AND METHODS:PANC-1 and AsPC-1 human pancreatic cancer cells were used as in vitro models to test the effects of PE. RESULTS:PE treatment induced cell cycle arrest and inhibited...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Nair V,Dai Z,Khan M,Ciolino HP

    更新日期：2011-09-01 00:00:00

  • Clinical significance of vimentin-positive gastric cancer cells.

    abstract：BACKGROUND/AIM:Vimentin expression in epithelial cells is reported to be associated with the malignant phenotype of cancer cells in vitro. However, the clinical significance of vimentin expression in carcinomas is not well understood. The aim of this study was to clarify the significance of vimentin-positive gastric ca...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Fuyuhiro Y,Yashiro M,Noda S,Kashiwagi S,Matsuoka J,Doi Y,Kato Y,Kubo N,Ohira M,Hirakawa K

    更新日期：2010-12-01 00:00:00

  • RT-PCR for Detecting ALK Translocations in Cytology Samples from Lung Cancer Patients.

    abstract：BACKGROUND/AIM:We evaluated the usefulness of reverse transcription-polymerase chain reaction (RT-PCR) for detecting anaplastic lymphoma kinase (ALK) translocations using cytology samples from lung cancer patients. MATERIALS AND METHODS:We analyzed ALK translocations by RT-PCR in cytology samples from lung cancer pati...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.11696

    authors： Nakamichi S,Seike M,Miyanaga A,Chiba M,Matsuda K,Kobayashi K,Takahashi A,Takeuchi S,Minegishi Y,Kubota K,Gemma A

    更新日期：2017-06-01 00:00:00

  • Reduced HIC-1 gene expression in non-small cell lung cancer and its clinical significance.

    abstract：BACKGROUND:HIC-1 (hypermethylated in cancer-1) is a candidate tumor suppressor gene, identified in a region of frequent loss of heterozygosity on chromosome 17p13.3, which is telomeric from TP53 and often deleted in surgically resected lung cancers. To determine the significance of HIC-1 in lung cancer, we assessed its...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Hayashi M,Tokuchi Y,Hashimoto T,Hayashi S,Nishida K,Ishikawa Y,Nakagawa K,Tsuchiya S,Okumura S,Tsuchiya E

    更新日期：2001-01-01 00:00:00

  • Doxorubicin cardiotoxicity and serum lipid increase is prevented by dextrazoxane (ICRF-187).

    abstract：:This study is related to the serious side effects of Doxorubicin-cardiotoxicity and serum lipid caused by the drug's cumulative effect. Studies were performed on experimental animals treated with intensive administration of Doxorubicin. Seventy five wistar rats were divided in two equal groups A and B. Group A was use...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Samelis GF,Stathopoulos GP,Kotsarelis D,Dontas I,Frangia C,Karayannacos PE

    更新日期：1998-09-01 00:00:00

  • High-density array comparative genomic hybridization detects novel copy number alterations in gastric adenocarcinoma.

    abstract：AIM:To investigate frequent quantitative alterations of intestinal-type gastric adenocarcinoma. MATERIALS AND METHODS:We analyzed genome-wide DNA copy numbers of 22 samples and using CytoScan® HD Array. RESULTS:We identified 22 gene alterations that to the best of our knowledge have not been described for gastric can...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Seabra AD,Araújo TM,Mello Junior FA,Di Felipe Ávila Alcântara D,De Barros AP,De Assumpção PP,Montenegro RC,Guimarães AC,Demachki S,Burbano RM,Khayat AS

    更新日期：2014-11-01 00:00:00

  • Effect of antitumor agents on cytotoxicity induction by sodium fluoride.

    abstract：:We have recently found that sodium fluoride (NaF) induced apoptotic cell death in tumor cell lines. We investigated here whether 6 popular antitumor compounds modify the cytotoxic activity of NaF against human squamous cell carcinoma (HSC-2) and human promyelocytic leukemia (HL-60) cell lines. Cytotoxic concentrations...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Morshed SR,Tokunaga T,Otsuki S,Takayama F,Satoh T,Hashimoto K,Yasui T,Okamura M,Shimada J,Kashimata M,Sakagami H

    更新日期：2003-11-01 00:00:00

  • Association of K-ras mutations with liver metastases from colorectal carcinoma.

    abstract：BACKGROUND:Colorectal carcinomas were studied regarding early proof of liver metastases through determination of K-ras mutations. PATIENTS AND METHODS:Seventy-seven colorectal carcinomas were investigated for the presence of point mutations in codon 12 and 13 of the K-ras gene, using single-strand conformation polymor...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Tsunoda A,Iijima T,Tsunoda Y,Nakao K,Miyaki M,Kusano M

    更新日期：2004-07-01 00:00:00

  • Involvement of p53 gene in the allelic deletion of chromosome 17p in human ovarian tumors.

    abstract：:Previous reports have shown that one copy of the chromosome 17 was frequently lost in human ovarian cancers (1). The position of the allelic deletion has not been mapped and involvement of p53 gene has not been determined. In this study, we have shown that in human ovarian carcinoma, the commonest region of allelic lo...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Tsao SW,Mok CH,Oike K,Muto M,Goodman HM,Sheets EE,Berkowitz RS,Knapp RC,Lau CC

    更新日期：1991-11-01 00:00:00

  • Effect of glutathione on alterations of liver DNA structure and metabolic activities induced in vivo by 2-acetylaminofluorene.

    abstract：:The effect on liver tissue of glutathione administration to rats treated for 7-14 days with 2-acetylaminofluorene was investigated. The DNA damage induced by the hepatotoxic agent and evaluated by the alkaline elution technique was significantly reduced by glutathione. Furthermore, GSH administration maintained liver ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Cesarone CF,Scarabelli L,Orunesu M

    更新日期：1986-11-01 00:00:00

  • Relation between carcinogenesis, chromatin structure and poly(ADP-ribosylation) (review).

    abstract：:Poly(ADP-ribose) is a naturally occurring nuclear macromolecule resembling nucleic acids. It is synthesized from NAD+ on histones and a few other nuclear proteins. Its function, although not completely understood, might be to alter chromatin structure and to regulate the activity of proteins involved in the metabolism...

    journal_title：Anticancer research

    pub_type： 杂志文章,评审

    doi：

    authors： Boulikas T

    更新日期：1991-03-01 00:00:00

  • Bcl2, p53 and clinical outcome in a series of 138 operable breast cancer patients.

    abstract：:Medical oncologists are increasingly interested in identifying reliable prognostic factors for breast cancer in order to distinguish subsets of breast cancer patients and to optimize therapeutic approaches. Among them, the p53 tumor suppressor gene and bcl2 protein continue to be extensively studied, but their role re...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Castiglione F,Sarotto I,Fontana V,Destefanis M,Venturino A,Ferro S,Cardaropoli S,Orengo MA,Porcile G

    更新日期：1999-09-01 00:00:00

  • Anti-tumor effect of N-beta-alanyl-5-S-glutathionyldihydroxyphenylalanine (5-S-GAD), a novel anti-bacterial substance from an insect.

    abstract：PURPOSE:We examined the anti-tumor effect of 5-S-GAD, a novel potent inhibitor of protein tyrosine kinases, isolated from the flesh fly in order to investigate the potential use of this compound as an anti-tumor agent. METHODS:In vitro growth inhibition was evaluated using the alamarBlue assay kit. In vivo anti-tumor ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Akiyama N,Hijikata M,Kobayashi A,Yamori T,Tsuruo T,Natori S

    更新日期：2000-01-01 00:00:00

  • Quantitative chemiluminescent immunoassay of p53: prognostic significance in 220 node-negative breast cancer tissue.

    abstract：:The prognostic and predictive role of p53 overexpression in breast cancer samples is usually investigated by using molecular biology or immunohistochemical methods. However, the results are to date controversial, and this is in part due to the methodological pitfalls of both the methods. To study the possibility of ov...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Dittadi R,Brazzale A,Mione R,Di Fresco S,Gatti C,Vinante O,Bassan F,Nascimben O,Gion M

    更新日期：1997-11-01 00:00:00

  • Site-specific modulation of carcinogen-induced gastrointestinal tract nuclear anomalies in B6C3F1 mice by chloroform.

    abstract：:Chloroform (CHCl3) is an established rodent carcinogen and a prevalent contaminant of chlorine-disinfected drinking water. Thus in the United States CHCl3, along with other trihalomethanes, is regulated not to exceed 100 ppb in potable water. Recently, several studies have shown that CHCl3 also has anti-cancer propert...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Daniel FB,Reddy TV,Stober JA,Olson GR

    更新日期：1991-03-01 00:00:00

  • Gastric Lavage Malignant Cells (yGL) and Hypohemoglobinemia (yAnemia) as New Systems of Tumor Regression Grading and Prognostic Prediction for Gastric Cancer After Neoadjuvant Treatment.

    abstract：BACKGROUND/AIM:Although reckoned necessary for survival benefit, neoadjuvant chemotherapy (NAC) of gastric cancer (GC) patients has so far provided questionable results. Consequently, searching for new and clearer systems of response to NAC, post-NAC re-evaluation and prognostic prediction appears essential. The purpos...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.13208

    authors： Virgilio E,Giarnieri E,Giovagnoli MR,Montagnini M,Proietti A,D'Urso R,Fegiz A,Mercantini P,Balducci G,Cavallini M

    更新日期：2019-02-01 00:00:00

  • In vivo inhibition by antioxidants of adriamycin-induced apoptosis in murine peritoneal macrophages.

    abstract：:Adriamycin (ADM) is an oncostatic of the anthracycline family with confirmed experimental and clinical efficiency. This antitumoral drug has been reported to stimulate macrophage activity and is able to induce apoptosis (AP) in some tumour cells. The objective of the present work was to investigate if in vivo administ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Dominguez-Rodriguez JR,Gomez-Contreras PC,Hernandez-Flores G,Lerma-Diaz JM,Carranco A,Cervantes-Munguia R,Orbach-Arbouys S,Bravo-Cuella A

    更新日期：2001-05-01 00:00:00

  • Mucinous Adenocarcinoma as a High-risk Factor in Stage II Colorectal Cancer: A Propensity Score-matched Study from Japan.

    abstract：BACKGROUND/AIM:The purpose of this study was to investigate the clinical, pathological, and prognostic differences between adenocarcinoma (ADC) and mucinous adenocarcinoma (MUC) in colorectal cancer (CRC). PATIENTS AND METHODS:This was a retrospective study of a Japanese high-volume cancer Center over a 10-year period...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.14115

    authors： Wang L,Hirano Y,Heng G,Ishii T,Kondo H,Hara K,Obara N,Asari M,Kato T,Yamaguchi S

    更新日期：2020-03-01 00:00:00

  • EBV Rta-induced IL-6 Promotes Migration of Bystander Tumor Cells Through IL-6R/JAK/STAT3 Pathway In Vitro.

    abstract：BACKGROUND/AIM:Rta, a transactivator of Epstein-Barr virus, is associated with progression of nasopharyngel carcinoma (NPC); however, its mechanism of contribution to the pathogenesis of NPC remains unclear. Interleukin-6 (IL-6), a tumor promoter, is detected in NPC. This in vitro study examined whether and how Rta pro...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.14307

    authors： Tung KL,Wu YT,Liu C,Lin SC,Wu CH,Wu SY,Chang Y,Lan YY

    更新日期：2020-06-01 00:00:00

  • Expression of Metallothionein I/II and Ki-67 Antigen in Graves' Disease.

    abstract：BACKGROUND/AIM:The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid. PATIENTS AND METHODS:MT-I/II and Ki-67 antigen expression was studie...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.13059

    authors： Domoslawski P,Pula B,Olbromski M,Wojtczak B,Lukienczuk T,Podhorska-Okolow M,Dziegiel P

    更新日期：2018-12-01 00:00:00

  • Apoptosis in human breast and gastrointestinal carcinomas. Detection in histological sections with monoclonal antibody to single-stranded DNA.

    abstract：:We report application of a novel immunohistochemical procedure for the staining of apoptotic (AP) cells in paraffin sections using monoclonal antibody (MAb) to single-stranded DNA. MAb differentiated between apoptosis and necrosis and in contrast to in situ end labelling specifically stained only AP cells. AP carcinom...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Frankfurt OS,Robb JA,Sugarbaker EV,Villa L

    更新日期：1996-07-01 00:00:00

  • Amentoflavone Enhances the Therapeutic Efficacy of Sorafenib by Inhibiting Anti-apoptotic Potential and Potentiating Apoptosis in Hepatocellular Carcinoma In Vivo.

    abstract：BACKGROUND/AIM:In a previous study, we showed that amentoflavone promotes sorafenib-induced apoptosis in hepatocellular carcinoma (HCC) cells in vitro. However, whether amentoflavone augments anticancer efficacy of sorafenib in HCC in vivo is unknown. The aim of the present study was to verify the anticancer effect of ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.12452

    authors： Tsai JJ,Hsu FT,Pan PJ,Chen CW,Kuo YC

    更新日期：2018-04-01 00:00:00

  • Down-regulation of CD28, TCR-zeta (zeta) and up-regulation of FAS in peripheral cytotoxic T-cells of primary breast cancer patients.

    abstract：BACKGROUND:Several studies have supported the hypothesis that the concept of immuno-surveillance would not be effective in cancer patients. One reason for suppression of antitumor immunity may be attributed to immune impairment of T-lymphocytes, which extends beyond the tumor-microenvironment and might effect the perip...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Gruber IV,El Yousfi S,Dürr-Störzer S,Wallwiener D,Solomayer EF,Fehm T

    更新日期：2008-03-01 00:00:00

  • Down-regulation of MiR-206 promotes proliferation and invasion of laryngeal cancer by regulating VEGF expression.

    abstract：:MicroRNAs (miRNA) are a class of small noncoding RNAs that regulate the expression of their target genes. The aim of the present study was to explore the effects of miR-206 on laryngeal suamous cell carcinoma (LSCC) cells. The expression level of miR-206 was quantified by qRT-PCR in primary LSCC tissues and correspond...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Zhang T,Liu M,Wang C,Lin C,Sun Y,Jin D

    更新日期：2011-11-01 00:00:00

  • 5,6-Dihydro-5'-azacytidine (DHAC) affects estrogen sensitivity in estrogen-refractory human breast carcinoma cell lines.

    abstract：BACKGROUND:There is little effective therapy for patients with hormone-refractory breast cancer. Hormone resistance is frequently due to the transcriptional inactivation of the estrogen receptor (ER) gene. We determined the effect of DHAC, a cytosine DNA methyltransferase (CMT) inhibitor, on the estrogen sensitivity in...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Izbicka E,Davidson KK,Lawrence RA,MacDonald JR,Von Hoff DD

    更新日期：1999-03-01 00:00:00

  • Lung cancer cell line sensitivity to Zoledronic acid is BAX-dependent.

    abstract：BACKGROUND:Zoledronate (Zol), an anti-osteoclastic and anticancer drug, is used to control bone metastasis in several cancer types, including non-small cell lung cancer (NSCLC). However, the mechanisms behind Zol resistance in NSCLC are unclear. MATERIALS AND METHODS:Zol-resistant cell lines were developed by repeated...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Aoyagi T,Morii T,Ohtsuka K,Ohnishi H,Tajima T,Yoshiyama A,Mochizuki K,Satomi K,Ichimura S

    更新日期：2013-12-01 00:00:00

  • Combination of Trabectedin With Irinotecan, Leucovorin and 5-Fluorouracil Arrests Primary Colorectal Cancer in an Imageable Patient-derived Orthotopic Xenograft Mouse Model.

    abstract：BACKGROUND/AIM:The aim of the present study was to determine the efficacy of trabectedin combined with FOLFIRI (irinotecan, leucovorin and 5-fluorouracil) on a colorectal cancer (CRC) patient-derived orthotopic xenograft (iPDOX) mouse model. MATERIALS AND METHODS:A CRC tumor from a patient previously established in nu...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.13860

    authors： Zhu G,Zhao M,Han Q,Tan Y,Sun YU,Bouvet M,Clary B,Singh SR,Ye J,Hoffman RM

    更新日期：2019-12-01 00:00:00

  • A preparatory regimen of total body irradiation, busulphan and melphalan for allogeneic bone marrow transplantation in childhood high-risk leukemia and lymphoma.

    abstract：:The therapeutic results of allogeneic bone marrow transplantation (BMT), following a conditioning regimen of total body irradiation and busulphan and melphalan administration, were evaluated in 20 pediatric patients with high-risk leukemia or lymphoma. Twelve patients received BMT from HLA-matched related (MR) donors ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Yoshihara T,Naya M,Tsunamoto K,Hojo M,Hibi S,Morimoto A,Todo S,Imashuku S

    更新日期：2003-03-01 00:00:00