Abstract：
BACKGROUND/AIM:Phenolic compounds isolated from Dendrobium ellipsophyllum Tang & Wang (Orchidaceae) have been shown to possess potential pharmacological activity; however, their anticancer as well as anti-metastasis activities are largely unknown. The aim of the present study was to isolate active compounds from D. ellipsophyllum and to explore the possible effects of phenolic compounds isolated from the plant for cytotoxic as well as anti-metastatic properties. MATERIALS AND METHODS:The compounds were isolated by using chromatographic techniques including silica gel and Sephadex LH20. Each of the isolates was evaluated for their cytotoxicity on H292 human lung cancer cell lines by 2,3-Bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide assay. The cytotoxic compounds were further evaluated for apoptosis-inducing and anoikis-sensitizing effects. RESULTS:Ten phenolic compounds were isolated, 5,7-dihydroxy-chromen-4-one (1:); 4,5-dihydroxy-2,3-dimethoxy-9,10-dihydrophenanthrene (2:); moscatilin (3:), 4,4'-dihydroxy-3,5-dimethoxybibenzyl (4:); 4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl (5:); (2S)-homoeriodictyol (6:); (2S)-eriodictyol (7:); chrysoeriol (8:); phloretic acid (9:); and luteolin (10:). Compounds 4:, 5:, 8: and 10: exhibited appreciable cytotoxic activity with 50% inhibitory concentration values less than 250 μM. These compounds also showed potential apoptosis induction and anoikis-sensitizing effect at non-toxic concentrations. CONCLUSION:Compounds 4:, 5:, 8: and 10: are responsible for cytotoxic and anti-metastatic activities of D. ellipsophyllum.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Tanagornmeatar K,Chaotham C,Sritularak B,Likhitwitayawuid K,Chanvorachote Psubject
Has Abstractpub_date
2014-11-01 00:00:00pages
6573-9issue
11eissn
0250-7005issn
1791-7530pii
34/11/6573journal_volume
34pub_type
杂志文章abstract：:The present study compared the effects of four lipophilic forms of selenium with regard to cancer chemopreventive activity, tissue selenium accumulation, and bioavailability for synthesis of a selenoprotein. These reagents included methylphenyl selenide, diphenyl selenide, triphenyl-selenonium chloride, and p-xylylbis...
journal_title：Anticancer research
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更新日期：1998-11-01 00:00:00
abstract：BACKGROUND/AIM:It is generally believed that the plasma concentration of 5-fluorouracil (5-FU) is constant when 5-FU is continually administered for chemotherapy. The aim of the present study was to verify whether this is true. PATIENTS AND METHODS:Nine patients with colorectal cancer were enrolled in this study. All ...
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pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：1997-03-01 00:00:00
abstract：: Aim: The aim of the study was to assess possible correlation of fluorogeoxyglucose (FDG) uptake and iodine-related attenuation values derived from positron-emission tomography/computed tomography (PET/CT) using single-source dual-energy CT scan (DE-CT) in non-small cell lung cancer (NSCLC). Materi...
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：1996-01-01 00:00:00
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doi：
更新日期：2010-02-01 00:00:00
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更新日期：2010-07-01 00:00:00
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doi：
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doi：10.21873/anticanres.11602
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doi：
更新日期：1989-09-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2009-08-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2006-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.14673
更新日期：2020-11-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,多中心研究
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更新日期：2018-03-01 00:00:00
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pub_type： 临床试验,杂志文章
doi：
更新日期：1994-11-01 00:00:00
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doi：
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doi：
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journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：2014-03-01 00:00:00
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journal_title：Anticancer research
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更新日期：1997-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：
更新日期：2012-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：2012-09-01 00:00:00
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doi：
更新日期：2014-06-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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