Combined gamma-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells.

abstract：:Inositol hexakisphosphate (InsP6) inhibits serine/threonine protein phosphatases type-1 (PP1), type-2A (PP2A) and type-3 (PP3) in a concentration-dependent manner. Since the activity of voltage-gated L-type Ca(2+)-channels is increased by inhibition of serine/threonine protein phosphatases, this may explain trhe incre...

journal_title：Anticancer research

authors： Barker CJ,Berggren PO

更新日期：1999-09-01 00:00:00

abstract：:The present study was undertaken to investigate cell death (particularly apoptosis) induced by etoposide, radiation, and both, and to examine p53 protein expression in relation to cell death. Nude mice transplanted with a human tumor (ependymoblastoma) were treated with etoposide (5-40 mg/kg) or 1-2 Gy X-ray irradiati...

journal_title：Anticancer research

authors： Toda H,Hasegawa M,Hayakawa K,Kawashima M,Nakamura Y,Yamakawa M,Mitsuhashi N,Niibe H

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Cyclin D1 is a key protein involved in cell cycle regulation. A common A870G single nucleotide polymorphism in exon 4 of the cyclin D1 gene (CCND1) has an effect on the transcription of two different cyclin D1 mRNAs. Association of the genetic polymorphism of A870G of CCND1 with several cancer risks has been...

journal_title：Anticancer research

authors： Koike H,Suzuki K,Satoh T,Ohtake N,Takei T,Nakata S,Yamanaka H

更新日期：2003-11-01 00:00:00

abstract：:35 patients suffering from malignant stage III/IV glioma were enrolled into a prospectively randomized clinical trial. All patients were provided with standard oncologic treatment (neurosurgery, radiation, basic clinical care according to protocol and indication) and randomly divided into a) treatment group: receiving...

journal_title：Anticancer research

authors： Lenartz D,Stoffel B,Menzel J,Beuth J

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND/AIM:Exposure of the skin to sunshine is the major natural source of vitamin D. In order to imitate this natural production of vitamin D for patients with chronic kidney disease, hemodialysis patients were exposed three times a week to radiation of the front part of both legs to normalize the vitamin D status...

journal_title：Anticancer research

authors： Krause R,Stange R,Roth HJ,Kaase H,Michalsen A,Holick MF

更新日期：2018-02-01 00:00:00

abstract：:The effect of selenite on mitochondrial morphology, selenoprotein synthesis, membrane potential, phosphorylating respiration, P/O ratio and respiratory control index were evaluated relative to selenite inhibition of DNA synthesis in murine mammary epithelial cell lines. No inhibition of mitochondrial function was note...

journal_title：Anticancer research

authors： Morrison DG,Pauly DF,Berdan RC,Dishart MK,Turner DS,Oborn CJ,Medina D

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Regardless of current multimodal treatment strategies, the prognosis of patients harboring glioblastoma multiforme (GBM) is still dismal. The introduction of concomitant radiochemotherapy and adjuvant cyclic temozolomide has significantly improved the overall survival, compared to postoperative radiotherapy-...

journal_title：Anticancer research

authors： Kerschbaumer J,Freyschlag CF,Bauer R,Obwegeser AA,Schubert GA,Thomé C,Seiz M

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:We investigated the influence of age on short-term complications in women undergoing intraoperative radiotherapy (IORT) for early breast cancer. PATIENTS AND METHODS:We retrospectively analyzed data of 188 women who underwent IORT during breast-conserving surgery (BCS). The study group consisted of 54 patie...

journal_title：Anticancer research

authors： Tuschy B,Berlit S,Romero S,Sperk E,Wenz F,Kehl S,Sütterlin M

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Different phenomena can result in enlargement of mental foramen and mandibular canal. At the foreground of diagnosis is the assessment of the biological properties of the tissue which causes such detailed lesions of the skeleton. CASE REPORT:This report describes a palpable mass at the site of the mental fo...

journal_title：Anticancer research

authors： Friedrich RE,Matschke J,Wilczak W

更新日期：2019-08-01 00:00:00

abstract：:The Feulgen-DNA content of squamous carcinoma cell nuclei from the human esophagus was assessed in punch biopsies from 47 untreated patients. Forty-four of the 47 biopsies (93.6%) demonstrated aneuploid cell populations, and the remaining 3 (6.4%) were non-diploid. Previous studies have demonstrated that in esophageal...

journal_title：Anticancer research

authors： Munck-Wikland E,Auer G,Kuylenstierna R,Lindholm J,Rubio C

更新日期：1989-05-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-E and HLA-F are classified as non-classical HLA class Ib antigens. Ectopic HLA-E and HLA-F expression was recently detected in cancer cells; however, the clinical implication of their expression remains unknown. A total of 209 patients with gastric cancer were enrolled in this study. Immu...

journal_title：Anticancer research

authors： Ishigami S,Arigami T,Okumura H,Uchikado Y,Kita Y,Kurahara H,Maemura K,Kijima Y,Ishihara Y,Sasaki K,Uenosono Y,Natsugoe S

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Malignant tumors of the sweat glands are very rare. Clear cell hidradenoma is a lesion with histopathological features resembling those of eccrine poroma and eccrine spiradenoma. The biological behavior of the tumor is aggressive, with local recurrences reported in more than 50% of the surgically-treated c...

journal_title：Anticancer research

authors： Liapakis IE,Korkolis DP,Koutsoumbi A,Fida A,Kokkalis G,Vassilopoulos PP

更新日期：2006-05-01 00:00:00

abstract：:In a retrospective analysis we investigated 59 children with de novo acute lymphoblastic leukemia (ALL) and 28 patients with relapsed ALL for the expression of cyclin D1 using RT-PCR. In addition, the relationships of cyclin D1 to the retinoblastoma tumor suppressor gene and the Ki-67-expression were analyzed. Cyclin ...

journal_title：Anticancer research

authors： Sauerbrey A,Häfer R,Zintl F,Volm M

更新日期：1999-01-01 00:00:00

abstract：:The identification of new prognostic parameters in Superficial Transitional Cell Carcinoma of the Bladder (STCCB) is important since conventional methods are often insufficient for prognostic purposes. We studied the proliferation activity and the DNA ploidy status of 60 pTa and pT1 Superficial Transitional Cell Carci...

journal_title：Anticancer research

authors： Pantazopoulos D,Ioakim-Liossi A,Karakitsos P,Aroni K,Kakoliris S,Kanavaros P,Kyrkou KA

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:DMXAA (5,6-dimethylxanthenone-4-acetic acid; AS1404), a vascular disrupting agent currently in clinical trials, induces tumour endothelial cell apoptosis in vivo in mice and in cancer patients. DMXAA activates NF-kappaB in many different cell types. In this study, whether DMXAA-induced endothelial cell apopt...

journal_title：Anticancer research

authors： Woon ST,Hung SS,Wu DC,Schooltink MA,Sutherland R,Baguley BC,Chen Q,Chamley LW,Ching LM

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIM:The clinical significance of surgery for secondary small intestinal non-Hodgkin's lymphomas (NHL) remains unknown. This study aimed to investigate the efficacy of resection for both primary and secondary small intestinal NHL. PATIENTS AND METHODS:Twenty patients with small intestinal lymphoma who underw...

journal_title：Anticancer research

authors： Iida T,Nozawa H,Sonoda H,Toyama K,Kawai K,Hata K,Tanaka T,Nishikawa T,Sasaki K,Shuno Y,Kaneko M,Murono K,Emoto S,Ishii H,Kurokawa M,Ishihara S

更新日期：2020-04-01 00:00:00

abstract：:Gallic acid induced apoptotic cell death in human promyelocytic leukemia HL-60 cells. The effect of gallic acid was significantly reduced by blocking the free hydroxyl or carboxyl group with acetyl, methyl, ethyl, n-propyl or isoamyl group. This was paralleled with the decrease in the intensity of both gallate radical...

journal_title：Anticancer research

authors： Sakagami H,Satoh K,Hatano T,Yoshida T,Okuda T

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Recently, metastasis associated with the colon cancer 1 (MACC1) gene was identified by genome-wide search for differentially expressed genes in human colon cancer tissues and metastases. Previously, the MACC1 expression levels were examined in colorectal carcinomas and it was found that MACC1 expression show...

journal_title：Anticancer research

authors： Shirahata A,Sakata M,Kitamura Y,Sakuraba K,Yokomizo K,Goto T,Mizukami H,Saito M,Ishibashi K,Kigawa G,Nemoto H,Hibi K

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is thought to be the most powerful angiogenic factor in many malignancies while and several reports have determined serum VEGF to be a prognostic indicator for various malignancies. However, serum VEGF may not be suitable for the measurement of circulating VEGF level...

journal_title：Anticancer research

authors： Nakayama Y,Sako T,Shibao K,Okazaki K,Rempo N,Onitsuka K,Minagawa N,Akahane K,Nagashima N,Nagata N,Itoh H

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Ethanol injection is widely used in liposome preparation. However, the parameters determining particle size distribution of the liposomal preparation has not been fully defined. MATERIALS AND METHODS:A syringe pump-driven microfluidic injection device was used to produce liposomes under different conditions...

journal_title：Anticancer research

authors： Pradhan P,Guan J,Lu D,Wang PG,Lee LJ,Lee RJ

更新日期：2008-03-01 00:00:00

abstract：:Various new aminosterols were synthesized. The antiproliferative activity of these compounds (I-IV) was studied in vitro on a continuous human non small-cell bronchopulmonary carcinoma line (NSCLC-N6) at the cell cycle level. The histograms indicate cell blockage in Phase Gl (compound I-III) associated with a reductio...

journal_title：Anticancer research

authors： el Kihel L,Bosch S,Dherbomez M,Roussakis C,Letourneux Y

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND/AIM:We aimed to analyze the clinical impact of solid and micropapillary components in a series of Japanese patients resected for ≤3 cm lung adenocarcinoma. PATIENTS AND METHODS:A total of 115 patients with ≤3 cm lung adenocarcinomas were reviewed and classified according to the American Thoracic Society and...

journal_title：Anticancer research

authors： Matsuoka Y,Yurugi Y,Takagi Y,Wakahara M,Kubouchi Y,Sakabe T,Haruki T,Araki K,Taniguchi Y,Nakamura H,Umekita Y

更新日期：2016-09-01 00:00:00

abstract：:Overexpression of p53-protein appears to be a common event in primary breast cancer. It has been proposed that the presence of elevated levels of this protein may be an independent prognostic factor and may be important for the ability of a tumor to metastasize. This study was performed to evaluate the influence of im...

journal_title：Anticancer research

authors： Hanzal E,Gitsch G,Kohlberger P,Dadak C,Miechowiecka N,Breitenecker G

更新日期：1992-11-01 00:00:00

abstract：AIM:To evaluate the tolerability and efficacy of oxaliplatin-based chemotherapy (OBC) in patients ≥ 75 years old with metastatic colorectal cancer (CRC). PATIENTS AND METHODS:We reviewed the medical records of 126 patients with unresectable stage IV CRC in terms of OBC administered as first-line chemotherapy whenever ...

journal_title：Anticancer research

authors： Fukuchi M,Ishibashi K,Tajima Y,Okada N,Yokoyama M,Chika N,Hatano S,Matsuzawa T,Kumamoto K,Kumagai Y,Baba H,Mochiki E,Ishida H

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND/AIM:The significance of microvascular invasion (MVI) of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) is unknown. PATIENTS AND METHODS:We studied 149 patients with solitary small-sized HCC (≤3 cm) who underwent hepatectomy, and developed a predictive model of MVI using independent facto...

journal_title：Anticancer research

authors： Imai K,Yamashita YI,Yusa T,Nakao Y,Itoyama R,Nakagawa S,Okabe H,Chikamoto A,Ishiko T,Baba H

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND/AIM:Leiomyosarcoma is an extremely rare, small bowel neoplasm (2% of all gastrointestinal tumours). Early diagnosis is challenging due to the slow growth of the cancer. The biological behaviour of this group of tumours is aggressive, and the first-line treatment is surgical resection. PATIENTS AND METHODS:T...

journal_title：Anticancer research

authors： Ferrari C,DI Domenico S,Mascherini M,Santoliquido M,Mastracci L,DE Cian F

更新日期：2020-07-01 00:00:00

abstract：:Chemotherapy (CT) in advanced and metastatic soft tissue sarcoma (STS) has a reported response rate of 17 to 30%, with a median survival of 30 months. Experimental and clinical studies have demonstrated some response with high-dose intravenous recombinant Interleukin-2 (r-IL2). We report a retrospective analysis of tw...

journal_title：Anticancer research

authors： Gravis G,Viens P,Delva R,Baume D,Blaise D,Ternier F,Houvenaeghel G,Brandely M,Resbeut M,Maraninchi D

更新日期：1998-09-01 00:00:00

abstract：:In a previous study we demonstrated spontaneous fragility and hypersensitivity to fragile site induction by aphidicolin in lymphocytes from some neuroblastoma patients and their parents. Here we report data based on a total of 40 patients and 37 families. Possible correlations between higher sensitivity to aphidicolin...

journal_title：Anticancer research

authors： Vernole P,Tedeschi B,Melino G,Pianca C,Nicoletti B

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Aberrant methylation of tumor suppressor gene (TSG) promoters has been extensively investigated in nasopharyngeal carcinomas (NPC) from South East Asia but not from North Africa. PATIENTS AND METHODS:The methylation status of p16, deleted in lung and esophageal cancer (DLEC1), zinc finger, MYND-type contain...

journal_title：Anticancer research

authors： Ayadi W,Karray-Hakim H,Khabir A,Feki L,Charfi S,Boudawara T,Ghorbel A,Daoud J,Frikha M,Busson P,Hammami A

更新日期：2008-07-01 00:00:00

abstract：:The question remains as to whether metastatic cells (cancer seed) that eventually colonize a particular organ (cancer soil) have specific properties that distinguish them from the other cells of the primary tumor. However until recently there have not been model systems in which this question could be fully answered. ...

journal_title：Anticancer research

authors： Togo S,Wang X,Shimada H,Moossa AR,Hoffman RM

更新日期：1995-05-01 00:00:00