Mitochondrial inclusions and mitochondrial respiratory function in selenite-treated mammary epithelial cell lines.

abstract：:Eighteen patients with advanced melanoma of the limbs underwent a single isolation perfusion with melphalan under normothermic conditions, i.e. tissue temperatures between 37.0 and 38.0 degrees C. There were no major complications. In 7 patients complete remission was achieved and in 8 the remission was partial, i.e. ...

journal_title：Anticancer research

authors： Kroon BB,Van Geel AN,Benckhuijsen C,Wieberdink J

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Periacetabular reconstruction after malignant bone tumor resection to preserve limb function is extremely challenging. The optimal reconstruction method has not yet received consensus and the functional outcomes still remain unsatisfactory. CASE REPORT:A thirteen-year-old girl who was suffering from acetabu...

journal_title：Anticancer research

authors： Kubo T,Sugita T,Shimose S,Tanaka H,Nobuto H,Tanaka K,Ochi M

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/AIM:The mechanism responsible for B-cell translocation gene 1 (BTG1) down-regulation in breast carcinoma remains unknown. We examined the BTG1 expression status in breast carcinoma cells and investigated the mechanism underlying the observed alterations. MATERIALS AND METHODS:Four breast carcinoma cell line...

journal_title：Anticancer research

authors： Woo HY,DO SI,Kim SH,Song SY,Kim HS

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSCs) are tumour-initiating cells with self-renewal properties and chemo/radio-resistance. Regulatory T-cells (Tregs) influence CSCs through several mechanisms. In different solid tumours, the presence of both cell populations correlated with poor survival. In vulvar cancer, little is know...

journal_title：Anticancer research

authors： Napoletano C,Bellati F,Ruscito I,Pernice M,Zizzari IG,Caponnetto S,Tomao F,Frigerio L,Liberati M,Rughetti A,Caserta D,Panici PB,Nuti M

更新日期：2016-10-01 00:00:00

abstract：:CPT-11 is a derivative of camptothecin, a topoisomerase-I inhibitor with marked cytotoxic activity. We examined the cytotoxicity of CPT-11 and its metabolite SN-38 for primary gastrointestinal carcinoma and various recurrent carcinomas which were cultured on contact-sensitive plates (CSPs). The response rate of seven ...

journal_title：Anticancer research

authors： Matsuoka H,Furusawa M,Tomoda H,Seo Y,Kono A,Takeda S,Sato K

更新日期：1994-03-01 00:00:00

abstract：:A rare case and the first reported in Italy of a classic form of colorectal Kaposi's sarcoma, associated with ulcerative rectocolitis, is presented. Following a total proctocolectomy, the patient was disease-free at four years. Some epidemiological risk factors such as sex, age, place of birth and both advanced malari...

journal_title：Anticancer research

authors： Tedesco M,Benevolo M,Frezza F,Mancini R,Carone MD,Mottolese M,Cosimelli M

更新日期：1999-07-01 00:00:00

abstract：:The antitumor effect of a polyamine biosynthetic pathway inhibitor methylglyoxal bis(cyclopentylamidinohydrazone) (MGBCP) on human osteosarcoma cell lines such as KHOS-240S, MG-63 and G-292 cells, and its effect in combination with anticancer drugs such as methotrexate (MTX), adriamycin (ADM) and 4-hydroperoxyfosfamid...

journal_title：Anticancer research

authors： Sonoda J,Hibasami H,Yamada H,Fujinami S,Nakashima K,Ogihara Y

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase 9 (MMP-9) plays an important role in cancer invasion and metastasis. The relationship between serum MMP-9 levels and clinicopathological factors in gastric cancer patients is not clear. MATERIALS AND METHODS:Preoperative serum was obtained from 170 patients who had undergone gastrec...

journal_title：Anticancer research

authors： Shen KH,Chi CW,Lo SS,Kao HL,Lui WY,Wu CW

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND/AIM:Nitric oxide (NO) functions have been studied in many cancer types, but rarely in head and neck squamous cell carcinoma (HNSCC). This study aimed to investigate the behavior of HNSCC cells following exposure to high NO (HNO). MATERIALS AND METHODS:Two pairs of isogenic HNSCC cell lines (HN18/HN17, HN30/...

journal_title：Anticancer research

authors： Utispan K,Koontongkaew S

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Recent data indicate the implication of an IGF/IGFBP/protease system in the development of ectopic implants of endometrium (endometriosis) in the pelvic cavity. MATERIAL AND METHODS:We characterized mitogens and protease(s) against IGFBP-3 in the peritoneal fluid of women with or without endometriosis using...

journal_title：Anticancer research

authors： Koutsilieris M,Lavergne E,Lemay A

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND/AIM:Pre-neoplastic lesions and renal cell tumors of distinct pheno- and genotypes occur frequently in end-stage kidneys. The aim of this study was to investigate the role of KRT7 and KRT19 in this process, the expression of which was previously detected by Affymetrix GeneChip analysis. PATIENTS AND METHODS:...

journal_title：Anticancer research

authors： Sarlos DP,Peterfi L,Szanto A,Kovacs G

更新日期：2018-09-01 00:00:00

abstract：:The karyotypes and selected isoenzymes of five cell lines, HU 961b, HU 1922, HU 609, HCV-29 and HU 1703 He, were characterized. These cell lines were derived either from histologically normal human urothelial cells or from transitional cell carcinoma (TCC) of the urinary bladder. They displayed different life span in ...

journal_title：Anticancer research

authors： Debiec-Rychter M,Christensen B,Kieler J,Wang CY

更新日期：1986-09-01 00:00:00

abstract：:Ovarian clear cell carcinoma represents a distinct histopathological subtype of epithelial ovarian cancer, with poor outcomes, especially in cases diagnosed in advanced stages of disease. However, even in these cases, it seems that the most effective treatment remains debulking surgery to no residual disease. We prese...

journal_title：Anticancer research

authors： Bacalbasa N,Balescu I,Filipescu A

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Disseminated tumor cells (DTCs) in bone marrow (BM) occur in 30-40% of primary breast cancer patients. An impaired bone microenvironment may lead to reduced bone density and osteoporosis affecting the BM as a homing site for DTCs. The bone mineral density (BMD) and its correlation to DTC in BM was evaluated....

journal_title：Anticancer research

authors： Kraemer B,Rothmund R,Banys M,Krawczyk N,Solomayer EF,Mack C,Wallwiener D,Fehm T

更新日期：2011-12-01 00:00:00

abstract：:The major purpose of this study was to define if the immunosuppressive effect of a transforming growth factor-beta (TGF-beta)-producing autologous tumor vaccine can be abrogated and rendered immunogenic by suppressing its TGF-beta secretion with antisense strategy. In this study, using a TGF-beta antisense gene modifi...

journal_title：Anticancer research

authors： Tzai TS,Shiau AL,Liu LL,Wu CL

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND/AIM:Activation of the c-JUN N-terminal kinase (JNK) signaling pathway has been associated with poor survival of ovarian cancer patients, but the role(s) and significance of JNK signaling in ovarian cancer cells remain poorly understood. In the present study, we aimed to investigate the role of JNK specifical...

journal_title：Anticancer research

authors： Seino M,Okada M,Shibuya K,Seino S,Suzuki S,Ohta T,Kurachi H,Kitanaka C

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Pemetrexed-induced eyelid edema is a rare side-effect of pemetrexed treatment. PATIENTS AND METHODS:Retrospective analysis of the incidence and severity of eyelid edema was conducted in patients treated with pemetrexed in a single institution. RESULTS:Eighty-six patients received pemetrexed-containing chem...

journal_title：Anticancer research

authors： Schallier D,Decoster L,Fontaine C,De Grève J

更新日期：2010-12-01 00:00:00

abstract：:Variations in dietary exposure to several minerals may alter the risk of acquiring colorectal cancer. These minerals include selenium, zinc, calcium, sodium, potassium, iron and fluoride. The mechanism by which each of these minerals alters cancer risk is not established. However, as both the epidemiologic and experim...

journal_title：Anticancer research

authors： Nelson RL

更新日期：1987-05-01 00:00:00

abstract：:Para-aminobenzoic acid (PABA) has been previously reported as being an inhibitor of DDP toxicity, and its use did not result in any observable loss in antitumor activity of DDP. The following studies investigated the effect of PABA on the pharmacokinetics and urinary excretion of cis-diamminedichloroplatinum(II) (DDP)...

journal_title：Anticancer research

authors： Esposito M,Vannozzi M,Viale M,Pellecchia C,Civalleri D,Gogioso L

更新日期：1995-11-01 00:00:00

abstract：:NMR spectroscopy was used to analyse perchloric acid extracts of normal human brain, murine brain cell cultures, glioblastoma tissue and the glioblastoma cell line U-87. 1H NMR spectra revealed the presence of elevated levels of UDP-N-acetylglucosamine and UDP-N-acetylgalactosamine in glioblastoma extracts and the gli...

journal_title：Anticancer research

authors： Sonnewald U,Isern E,Gribbestad IS,Unsgård G

更新日期：1994-05-01 00:00:00

abstract：:Gastric involvement is unusual in primary mediastinal large B-cell lymphoma (PMLBCL), which has not yet been adequately studied. The aim of this retrospective study was to investigate the frequency of gastric involvement in 204 consecutive patients with PMLBCL that presented at 23 hospitals in Greece. Two out of 204 p...

journal_title：Anticancer research

authors： Papageorgiou SG,Sachanas S,Pangalis GA,Tsopra O,Levidou G,Foukas P,Rondogianni P,Sotiropoulos V,Ioannidou HD,Gassiamis A,Iliakis T,Korkolopoulou P,Angelopoulou MK,Pappa V,Konstantopoulos K,Vassilakopoulos TP

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND/AIM:The expression of corticotropin-releasing hormone (CRH)-related peptides involved in stress response in colorectal cancer has been reported. We examined the involvement of CRH-related peptides in cellular stress caused by anticancer drugs in colorectal cancer. MATERIALS AND METHODS:Changes in the expres...

journal_title：Anticancer research

authors： Kuwata GO,Ikeda K,Manome Y

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND/AIM:Basaloid squamous cell carcinoma of the oesophagus (BSCCE) is a variant of oesophageal squamous cell carcinoma (ESCC), that has a more aggressive biological behaviour than that of typical ESCC. miR-3687 has been previously identified to be highly expressed in BSCCE. This study aimed to evaluate the progn...

journal_title：Anticancer research

authors： Hagio K,Furuya S,Nakamura J,Maruyama S,Shiraishi K,Shimizu H,Akaike H,Hosomura N,Kawaguchi Y,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Ichikawa D

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND/AIM:Secretory phospholipase-A2 (sPLA2) mediates growth and proliferation of human esophageal adenocarcinoma cells (HEAC). Two major molecular pathways of cancer growth regulation include extracellular signal-regulated kinase 1/2 (ERK 1/2) and protein kinase-B (AKT). Phospholipase enzymes have been demonstrat...

journal_title：Anticancer research

authors： Sadaria MR,Yu JA,Meng X,Fullerton DA,Reece TB,Weyant MJ

更新日期：2013-04-01 00:00:00

abstract：:Flunarizine, a calcium-antagonist drug that binds to calmodulin, was found to inhibit the migration of both B16 melanoma cells and M5076 macrophage-like cancer cells. The migration movement, both under agarose and through a polycarbonate filter membrane, was impaired by the drug. In M5076 macrophage-like cells Fc-depe...

journal_title：Anticancer research

authors： Sezzi ML,De Luca G,Materazzi M,Bellelli L

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Nucleotide-binding domain and leucine-rich repeat-containing family, pyrin domain-containing 7 (NLRP7) (pyrin-containing apoptotic protease activating factor-1-like protein 3; PYPAF3, NACHT domain-, leucine-rich repeat, and pyrin domain-containing 7; NALP7) has been thought to contribute to innate immunity a...

journal_title：Anticancer research

authors： Ohno S,Kinoshita T,Ohno Y,Minamoto T,Suzuki N,Inoue M,Suda T

更新日期：2008-07-01 00:00:00

abstract：:To evaluate further the chemopreventive role of motherwort (Leonurus sibiricus L; MW) in lesions of the mammary gland and uterus of GR/A mice, the effects on these lesions of the adsorbed (MW1) and unadsorbed (MW2) fractions of MW separated by ion-exchange resins were studied. The incidence of palpable mammary tumours...

journal_title：Anticancer research

authors： Nagasawa H,Inatomi H,Suzuki M,Mori T

更新日期：1992-01-01 00:00:00

abstract：:Overexpression of p53-protein appears to be a common event in primary breast cancer. It has been proposed that the presence of elevated levels of this protein may be an independent prognostic factor and may be important for the ability of a tumor to metastasize. This study was performed to evaluate the influence of im...

journal_title：Anticancer research

authors： Hanzal E,Gitsch G,Kohlberger P,Dadak C,Miechowiecka N,Breitenecker G

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Ano-genital carcinoma is a polyfactorial and polygenic disease. Certain strains of human papillomavirus (HPV) have been detected in a high percentage of patients. It has been suggested that p53 polymorphisms may be relevant for the interaction with viral proteins that inactivates p53. MATERIALS AND METHODS:...

journal_title：Anticancer research

authors： Realacci M,Perrone GA,Sale P,Tafani M,Di Vito M,Perrone-Donnorso R,Zotti G,Russo MA

更新日期：2006-07-01 00:00:00

abstract：:The effect of indomethacin, cisplatin and delta 12-prostaglandin J2 (PGJ2) on the inhibition of cell growth and DNA Synthesis (i.e. cell proliferation), was evaluated in vitro on human oral squamous carcinoma cells(SCC-25). The rank order of their inhibitory potency at 10(-5) M was delta 12-PGJ2 > cisplatin > indometh...

journal_title：Anticancer research

authors： el Attar TM,Virji AS

更新日期：1997-11-01 00:00:00