Partial Body UV Exposure in Chronic Kidney Disease and Extrarenal Vitamin D Metabolism.

abstract：:We investigated the signal transduction pathway to low-dose radiation-induced apoptosis in vitro in the human peripheral primitive neuroectodermal tumor (pPNET) cell line with wild-type p53 established in our laboratory. Apoptosis was induced by 2Gy irradiation in an almost p53-dependent manner in this model except fo...

journal_title：Anticancer research

authors： Imai R,Akimoto T,Maebayashi K,Ishikawa H,Sakurai H,Saitoh J,Hasegawa M,Mitsuhashi N,Nakano T

更新日期：2002-09-01 00:00:00

abstract：:Primary cultures from 30 human gliomas (26 high grade, 3 low grade, and one oligoastrocytoma) were studied to examine the mixture of cells that make up the outgrowth, and their interactions. GFAP + ve Fibronectin - ve cells had a predominantly process forming (PF) morphology and formed complex networks around explants...

journal_title：Anticancer research

authors： Franks AJ,Burrow HM

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:The secretory epithelial cells of the prostate gland use sophisticated vehicles in the form of prostasomes to relay important information to sperm cells in semen. This prostasome-forming and secretory ability of the epithelial cells is also preserved in poorly differentiated prostate cancer cells. The aim of...

journal_title：Anticancer research

authors： Ronquist KG,Ronquist G,Larsson A,Carlsson L

更新日期：2010-02-01 00:00:00

abstract：AIM:To compare clinical outcome in patients with Child-Pugh C hepatocellular carcinoma (HCC) treated with non-transplant therapies and those treated with best supportive care. PATIENTS AND METHODS:A total of 182 patients with HCC with Child-Pugh C cirrhosis were analyzed. Patients were classified into two groups: pati...

journal_title：Anticancer research

authors： Nishikawa H,Kita R,Kimura T,Ohara Y,Takeda H,Sakamoto A,Saito S,Nishijima N,Nasu A,Komekado H,Osaki Y

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:SagA1 and SagA2 molecules produced from beta-hemolytic Streptococcus anginosus subsp. anginosus are composed of a leader peptide and a propeptide, and their mature form has hemolytic activity as a well-known Streptococcal peptide toxin, streptolysin. The function of these SagA molecules is thought to be depe...

journal_title：Anticancer research

authors： Kawaguchi Y,Tabata A,Nagamune H,Ohkura K

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Various localized side effects which accompany head and neck irradiation [IR] have been widely reported. However, systemic side effects/have been only sparsely reported in the short-term period post-IR in an animal model. The potential modulatory role of zinc-desferrioxamine [Zn-DFO] on IR effects was examin...

journal_title：Anticancer research

authors： Nagler RM,Barak V,Nagler A

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:A number of association studies have focused on the effect of polymorphisms related to DNA repair or the xenobiotic pathway, on the susceptibility to gastric cancer (GC). Here, the possible association between common polymorphisms in the X-ray repair cross-complementing groups (XRCC) 1, and glutathione-S-tra...

journal_title：Anticancer research

authors： Tahara T,Shibata T,Nakamura M,Yamashita H,Yoshioka D,Okubo M,Yonemura J,Ishizuka T,Maruyama N,Kamano T,Kamiya Y,Fujita H,Nakagawa Y,Nagasaka M,Iwata M,Yamada H,Hirata I,Arisawa T

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Mistletoe lectins (ML), the major biologically active components of mistletoe extracts, which are used for adjuvant cancer therapy, induce apoptosis in lymphocytes and tumor cells. In addition, ML at toxic concentrations induce the release of cytokines, but it remains unclear as to whether dying or activated...

journal_title：Anticancer research

authors： Stein GM,Pfüller U,Schietzel M,Büssing A

更新日期：2000-05-01 00:00:00

abstract：:Inv(3)(q21q26)/t(3;3)(q21;q26) is a feature of a distinctive entity of acute myeloid leukemia (AML) associated with normal or elevated platelet count, atypical megakaryocytes and multilineage dysplasia in the bone marrow, as well as minimal to no response to chemotherapy and poor clinical outcome. The presence of an i...

journal_title：Anticancer research

authors： De Braekeleer E,Douet-Guilbert N,Le Bris MJ,Ianotto JC,Berthou C,Gueganic N,Bovo C,Basinko A,Morel F,De Braekeleer M

更新日期：2013-02-01 00:00:00

abstract：UNLABELLED:In a previous report we noted that cyclooxygenase-2 (COX-2) expression in clinical colorectal cancer is closely related to liver metastasis and survival. The aim of the present study was to clarify the role of COX-2 in liver metastasis and to examine the potential for a selective COX-2 inhibitor as a novel t...

journal_title：Anticancer research

authors： Yamauchi T,Watanabe M,Hasegawa H,Nishibori H,Ishii Y,Tatematsu H,Yamamoto K,Kubota T,Kitajima M

更新日期：2003-01-01 00:00:00

abstract：:The cyanoguanidine CHS 828 was recently shown to possess potent anti-tumour effects both in vitro and in vivo. The exact mechanism of action of CHS 828 is not known, but recent results have indicated that induction of programmed cell death may be one mechanism by which CHS 828 exerts its anti-tumour effects. To invest...

journal_title：Anticancer research

authors： Hansen CM,Hansen D,Holm PK,Larsson R,Binderup L

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Small cell neuroendocrine cervical carcinoma (SCNCC) is a rare tumor that comprises 1-3% of cervical tumors. SCNCC exhibits clinical and biological characteristics of both cervical neoplasm (such as local aggressiveness and involvement of papillomavirus) and neuroendocrine small cell cancer of any site (such...

journal_title：Anticancer research

authors： Bifulco G,Mandato VD,Giampaolino P,Piccoli R,Insabato L,De Rosa N,Nappi C

更新日期：2009-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) constitute a dominating class of small RNAs that regulate diverse cellular functions. Due the pivotal role of miRNAs in biological processes, a deregulated miRNA expression is likely involved in human cancers. MicroRNAs possess tumor suppressor capability, as well as display oncogenic characteristic...

journal_title：Anticancer research

authors： D'Angelo B,Benedetti E,Cimini A,Giordano A

更新日期：2016-11-01 00:00:00

abstract：:Mutations in the p53 gene occur frequently in bladder cancers. Better prognostic factors are needed to help select appropriate treatment for patients with TCC stage T1. Paraffin-embedded tumors from 73 patients with TCC stage T1 were processed for two-parameter flow cytometry, measuring both p53 protein and DNA. There...

journal_title：Anticancer research

authors： Vatne V,Maartmann-Moe H,Hoestmark J

更新日期：1994-11-01 00:00:00

abstract：:A new cell line, designated CC2/CUHK2, was established from a squamous carcinoma of the uterine cervix from a Chinese patient. The cell line grew well without interruption for over 12 months and over 90 passages. The doubling time of CC2/CUHK2 was 72 hours at passage 57. When seeded at a density of 1.5 x 10(3) cells p...

journal_title：Anticancer research

authors： Ho TH,Chew EC,Tam JS,Hou HJ,Yam HF,Chew-Cheng SB,Wong FW

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Pleomorphic rhabdomyosarcomas of the uterus, mainly occurring in postmenopausal women with leading symptoms of vaginal bleeding and abdominal pain, are very rare malignant tumors of the female genital tract. Due to the inefficiency of the adjuvant therapy, the outcome remains poor in the majority of the repo...

journal_title：Anticancer research

authors： Alavi S,Eckes L,Kratschell R,Taube ET,Rosseck F,Wieners G,Sehouli J

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:It was recently reported that expression of prospero homeobox protein-1 (PROX1) is correlated with the prognosis of esophageal cancer and colorectal cancer. However, its correlation with gastric cancer is unclear. MATERIALS AND METHODS:Our study analyzed the effect of PROX1 knockdown on the migration, invas...

journal_title：Anticancer research

authors： Ueta K,Otowa Y,Kakeji Y,Hirashima M

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND/AIM:Polyamines are important for the growth of eukaryotic cells. At high levels, they promote proliferation, invasion and migration of tumour cells. Polyamine metabolism is an important new target for anticancer therapy. Some polyamine analogues can have an inhibitory effect on tumour cells. The aim of this ...

journal_title：Anticancer research

authors： Ploskonos MV,Syatkin SP,Neborak EV,Hilal A,Sungrapova KY,Sokuyev RI,Blagonravov ML,Korshunova AY,Terentyev AA

更新日期：2020-03-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) represent the most common mesenchymal tumor entity of the gastrointestinal tract. In fewer than 5% of cases, primary GISTs are located in the duodenum. Surgery represents the treatment of choice for localized tumor disease and remains challenging in GISTs located at the duodenum...

journal_title：Anticancer research

authors： Mrak K,Liegl-Atzwanger B,Haybaeck J,Petritsch W,Mischinger HJ,Kornprat P

更新日期：2015-11-01 00:00:00

abstract：:Ovarian cancer is the most lethal malignancy among gynaecological cancers. Although many anticancer agents have been developed for the treatment of ovarian cancer, it continues to have an extremely poor prognosis. Heparin-binding epidermal growth factor-like grown factor (HB-EGF) has been reported to be a rational the...

journal_title：Anticancer research

authors： Miyata K,Yotsumoto F,Fukagawa S,Kiyoshima C,Ouk NS,Urushiyama D,Ito T,Katsuda T,Kurakazu M,Araki R,Sanui A,Miyahara D,Murata M,Shirota K,Yagi H,Takono T,Kato K,Yaegashi N,Akazawa K,Kuroki M,Yasunaga S,Miyamoto S

更新日期：2017-07-01 00:00:00

abstract：:Vitamin D is a steroid hormone traditionally recognized for maintaining calcium and phosphorous homeostasis in the body. However, it is now widely accepted that it exerts several extraskeletal actions, including anti-tumorigenic and immunomodulatory effects in vitro and in vivo. There is now a huge interest in studyin...

journal_title：Anticancer research

authors： Norton R,O'Connell MA

更新日期：2012-01-01 00:00:00

abstract：UNLABELLED:AIM/ BACKGROUND: To determine the feasibility and safety of intratumoral α-gal glycolipids injection for conversion of human tumors into autologous Tumor Associated Antigens (TAA) vaccine. α-Gal glycolipids bind anti-Gal--the most abundant antibody in humans. Pre-clinical studies indicated that injected α-ga...

journal_title：Anticancer research

authors： Whalen GF,Sullivan M,Piperdi B,Wasseff W,Galili U

更新日期：2012-09-01 00:00:00

abstract：:In the colon of F344 rats treated with 2 x 15 mg/kg body weight of azoxymethane (AOM), the density (number of lesions/cm2/rat) of flat aberrant crypt foci (ACF) was 13-fold higher (p < 0.05) in the surface area of mucosa immediately adjacent to lymphoid follicles compared with the density of these lesions in the rest ...

journal_title：Anticancer research

authors： Paulsen JE,Steffensen IL,Olstørn HB,Alexander J

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this retrospective study was to detect the frequency, reasons, and significant factors for not receiving immunotherapy after chemoradiotherapy in non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS:Thirty-four patients with NSCLC received definitive chemoradiotherapy. The endpoi...

journal_title：Anticancer research

authors： Morimoto M,Nishino K,Wada K,Imamura F,Konishi K,Kuhara H,Tamiya M,Inoue T,Kunimasa K,Kimura M,Hirata T,Kanayama N,Toratani M,Kawachi H,Ohira K,Nakanishi E,Ohira S,Sagawa T,Miyazaki M,Matsunaga T,Kumagai T,Teshim

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:It is unclear whether radiomic phenotypes of brain metastases (BM) are related to radiation therapy prognosis. This study assessed whether a convolutional neural network (CNN)-based radiomics model which learned computer tomography (CT) image features with minimal preprocessing, could predict early response ...

journal_title：Anticancer research

authors： Cha YJ,Jang WI,Kim MS,Yoo HJ,Paik EK,Jeong HK,Youn SM

更新日期：2018-09-01 00:00:00

abstract：:The development of cisplatin drug resistance remains a chief concern in ovarian cancer chemotherapy. β-Elemene is a natural plant product with broad-spectrum antitumor activity towards many types of carcinomas. This study aimed to define the biological and therapeutic significance of β-elemene in chemoresistant ovaria...

journal_title：Anticancer research

authors： Lee RX,Li QQ,Reed E

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Several types of human papilloma virus (HPV) have been associated with increased risk for epithelial malignancies. In light of a recently available vaccine that protects against persistent infection by certain HPV types (6, 11, 16, 18) and resulting neoplasias, the prevalence of HPV types was investigated in...

journal_title：Anticancer research

authors： Yapijakis C,Adamopoulou M,Antonopoulos G,Koufaliotis N,Vairaktaris E

更新日期：2008-07-01 00:00:00

abstract：:Initial events in the metastatic spread of tumours involve loss of cell-cell adhesion within the primary tumour mass. The integrity and morphology of epithelial tumour cell colonies is maintained primarily by cell-cell adhesions mediated by E-cadherin and its associated intracellular catenin molecules. Hepatocyte grow...

journal_title：Anticancer research

authors： Hiscox S,Jiang WG

更新日期：1999-01-01 00:00:00

abstract：:The effects of dibutyryl cyclic AMP (DBcAMP) on tissue inhibitor metalloproteinase (TIMP) expression were studied in the human hepatoma cell line PLC/PRF/5 with relation to the invasive activity of the cells. Messenger RNA expression levels of metalloproteinases (MMP)-2 and 9, and TIMP-1, 2 and 3 in the cells were det...

journal_title：Anticancer research

authors： Okamoto Y,Nakano H

更新日期：1999-11-01 00:00:00

abstract：:Molecular chaperones, many of which are heat-shock proteins (HSPs), are an important class of molecules with various functions. Pathological conditions in which chaperones become etiological and/or pathogenic factors are called chaperonopathies, and are classified into by defect, by excess, and by 'mistake'. In the la...

journal_title：Anticancer research

authors： Rappa F,Farina F,Zummo G,David S,Campanella C,Carini F,Tomasello G,Damiani P,Cappello F,DE Macario EC,Macario AJ

更新日期：2012-12-01 00:00:00