Cancer immunotherapy by intratumoral injection of α-gal glycolipids.

Abstract:

UNLABELLED:AIM/ BACKGROUND: To determine the feasibility and safety of intratumoral α-gal glycolipids injection for conversion of human tumors into autologous Tumor Associated Antigens (TAA) vaccine. α-Gal glycolipids bind anti-Gal--the most abundant antibody in humans. Pre-clinical studies indicated that injected α-gal glycolipids insert into tumor cell membranes, bind anti-Gal and target tumor cells to Antigen Presenting Cells, thereby converting tumors into autologous TAA vaccines. We hypothesized that α-gal glycolipids might have similar utility in humans. PATIENTS AND METHODS:Eleven patients with advanced solid tumors received one intratumoral injection of 0.1 mg, 1 mg, or 10 mg α-gal glycolipids. The primary endpoint was dose-limiting toxicity (DLT) within 4 weeks. Secondary endpoints included long-term toxicity, autoimmunity, radiological tumor response and survival. RESULTS:There were no DLT and no clinical or laboratory evidence of autoimmunity, or any other toxicity. Few patients had an unexpectedly long survival. CONCLUSION:Intratumoral injection of α-gal glycolipids is feasible and safe for inducing a protective anti-tumor immune response.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Whalen GF,Sullivan M,Piperdi B,Wasseff W,Galili U

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

3861-8

issue

9

eissn

0250-7005

issn

1791-7530

pii

32/9/3861

journal_volume

32

pub_type

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