MicroRNAs: A Puzzling Tool in Cancer Diagnostics and Therapy.

abstract：BACKGROUND:The epithelial-mesenchymal transition is a critical early event in the invasion and metastasis of many types of cancer, including colorectal cancer (CRC). Chronic inflammation is an inducer of several cancer types and inflammatory cytokines have been implicated in tumor invasion. MATERIALS AND METHODS:Human...

journal_title：Anticancer research

authors： Bowen KA,Doan HQ,Zhou BP,Wang Q,Zhou Y,Rychahou PG,Evers BM

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:The efficacy of systemic chemotherapy for peritoneal dissemination of gastric cancer remains unclear. The efficacy of weekly paclitaxel in combination with doxifluridine (5'-DFUR) in gastric cancer patients with malignant ascites was evaluated. PATIENTS AND METHODS:Patients with histologically confirmed gas...

journal_title：Anticancer research

authors： Takeyoshi I,Makita F,Iwazaki S,Ishikawa H,Kakinuma S,Sato Y,Ohya T,Nakagami K,Tomizawa N,Izumi M,Kobayashi I,Tanahashi Y,Kobayashi J,Kamoshita N,Kawate S,Sunose Y,Sakamoto I,Yoshinari D,Yamada T,Okabe T

更新日期：2011-12-01 00:00:00

abstract：:Metastatic spread of malignancy is the primary cause of treatment failure and subsequent death in cancer patients. All cancers have the capability to metastasize, however, there are notable exceptions which rarely if ever metastasize. These include basal cell carcinoma, or cancers which are primarily locally invasive ...

journal_title：Anticancer research

authors： Kohn EC

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Peroxisome proliferator activated receptor gamma (PPARgamma) involvement in thyroid tumorigenesis has recently been studied, especially in follicular neoplasms. Conflicting results concerning the regulation of this receptor in human papillary carcinoma have been reported. Therefore, we quantitatively assesse...

journal_title：Anticancer research

authors： Galusca B,Dumollard JM,Chambonniere ML,Germain N,Prades JM,Péoc'h M,Estour B

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/AIM:Neoplastic spindle cells (NSCs) are believed to play a role in cancer invasion and metastasis, as well as in poor prognosis. The clinicopathological characteristics and prognostic relevance of NSCs was investigated in gallbladder cancer. MATERIALS AND METHODS:Specimens were obtained from 62 patients wit...

journal_title：Anticancer research

authors： Midorikawa R,Hisaka T,Sakai H,Nomura Y,Goto Y,Sato T,Kawahara R,Ishikawa H,Fujita F,Yasunaga M,Tanigawa M,Naito Y,Akiba J,Yano H,Tanaka H,Akagi Y,Okuda K

更新日期：2019-08-01 00:00:00

abstract：:Neutralizing single-domain antibodies directed towards catalase or superoxide dismutase (SOD) caused efficient reactivation of intercellular reactive oxygen species/reactive nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling specifically in human tumor cells. Single-domain antibodies targeted tumor cell...

journal_title：Anticancer research

authors： Bauer G,Motz M

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) have been linked to a number of cancer types including breast cancer. The rate of brain metastases is 10-30% in patients with advanced breast cancer which is associated with poor prognosis. The potential application of miRNAs in the diagnostics and therapeutics of breast cancer with brain ...

journal_title：Anticancer research

authors： Li Z,Peng Z,Gu S,Zheng J,Feng D,Qin Q,He J

更新日期：2017-08-01 00:00:00

abstract：AIM:Despite recent improvements in treatment strategies, the results of chemotherapy in patients with advanced squamous cell carcinoma of the larynx are not satisfactory. Thus, the development of new approaches which influence specific metabolic pathways are needed. In the last decade, evidence has emerged implicating ...

journal_title：Anticancer research

authors： Stepulak A,Luksch H,Uckermann O,Sifringer M,Rzeski W,Polberg K,Kupisz K,Klatka J,Kielbus M,Grabarska A,Marzahn J,Turski L,Ikonomidou C

更新日期：2011-02-01 00:00:00

abstract：:The antitumor effects of the somatostatin structural derivative TT-232 in different rodent and xenograft tumor models are summarized in this report. TT-232 had previously been shown to inhibit the proliferation of a large number of cancer cell lines in vitro and reduce the size of different tumors in animal models in ...

journal_title：Anticancer research

authors： Tejeda M,Gaál D,Hullán L,Hegymegi-Barakonyi B,Kéri G

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND/AIM:Chest radiotherapy (RT) doubles late cardiac mortality. This study aimed to evaluate the evolution of cardiac changes in speckle tracking echocardiography during a three-year follow-up. MATERIALS AND METHODS:This prospective study included 81 chemotherapy-naïve early-stage breast cancer patients who wer...

journal_title：Anticancer research

authors： Tuohinen SS,Skytta T,Huhtala H,Virtanen V,Kellokumpu-Lehtinen PL,Raatikainen P

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Women with recurrent ovarian cancer have a poor prognosis and short survival. However, some women are long-term survivors and it is unclear whether they share specific common characteristics. CASE REPORT:We present the case of a 63-year-old woman with histologically-proven recurrent ovarian cancer and a sur...

journal_title：Anticancer research

authors： Hilal Z,Schultheis B,Hartmann F,Dogan A,Cetin C,Krentel H,Schiermeier S,Tempfer CB

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:CD44 is a transmembrane glycoprotein and is associated with cell-matrix and cell-cell interactions. CD44 expression was shown to be relevant to tumour progression in various types of human cancer. The objective of this study was to investigate the relationship between the expression levels of the standard fo...

journal_title：Anticancer research

authors： Al-Maghrabi J,Gomaa W,Buhmeida A,Al-Qahtani M,Al-Ahwal M

更新日期：2012-08-01 00:00:00

abstract：AIM:To describe the feasibility, safety, and oncological outcomes of a modified triple-incision total radical vulvectomy and inguino-femoral lymphadenectomy in patients with locally advanced squamous vulvar cancer. PATIENTS AND METHODS:A modified triple-incision technique performed by two surgical teams operating simu...

journal_title：Anticancer research

authors： Fambrini M,Sorbi F,Sisti G,Checcucci V,Cariti G,Scotti V,Tinacci E,Turrini I,Micaglio M,De Magnis A

更新日期：2014-12-01 00:00:00

abstract：:Metastatic urothelial carcinoma is one of the most fatal urological malignancies. Cisplatin-based systemic chemotherapy is the standard treatment for metastatic urothelial carcinoma, and there is little evidence to support metastasectomy. The aims of the study were to evaluate the efficacy of metastasectomy and to inv...

journal_title：Anticancer research

authors： Iwamoto H,Izumi K,Shimura Y,Natsagdorj A,Maolake A,Takezawa Y,Nohara T,Shigehara K,Kadono Y,Mizokami A

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND/AIM:NME/NM23 nucleoside diphosphate kinase 1 (NME1) is a metastasis suppressor gene, exhibiting reduced expression in metastatic cancers and the ability to suppress metastatic activity of cancer cells. We previously identified NME1-regulated genes with prognostic value in human melanoma. This study was condu...

journal_title：Anticancer research

authors： Pamidimukkala NV,Leonard MK,Snyder D,McCorkle JR,Kaetzel DM

更新日期：2018-11-01 00:00:00

abstract：:An immunohistochemical study of 155 squamous cell carcinomas of the oesophagus, squamous epithelium adjacent to the tumour (n = 80), dysplastic epithelium (n = 16) and controls (n = 23) indicates that Ki67 and p53 expression is frequently present in premalignant oesophageal lesions and their related squamous cell carc...

journal_title：Anticancer research

authors： Jaskiewicz K,De Groot KM

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:To determine the tolerability and efficacy of the combination of gefitinib with gemcitabine plus vinorelbine in metastatic breast cancer (MBC) patients, pretreated with anthracyclines and taxanes. PATIENTS AND METHODS:Women with measurable MBC pretreated with anthracycline- and taxane-based chemotherapy receiv...

journal_title：Anticancer research

authors： Gioulbasanis I,Saridaki Z,Kalykaki A,Vamvakas L,Kalbakis K,Ignatiadis M,Amarantidis K,Kakolyris S,Georgoulias V,Mavroudis D

更新日期：2008-09-01 00:00:00

abstract：:The in vitro cytotoxicity and differential cellular sensitivity of a series of new N1-methyl, N1-allyl, N1-2-chloroethyl and N1-propargyl nitrosourea derivatives of diamino acids were determined in the National Cancer Institute's primary antitumor drug screen. The compounds tested showed an in vitro anticancer activit...

journal_title：Anticancer research

authors： Dulude H,Salvador R,Gallant G

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Because of clinicopathologic and genetic differences between left-sided colorectal cancer (LSCRC) and right-sided colon cancer (RSCC), cyclooxygenase-2(COX-2) and adenomatous polyposis coli (APC) expression may be of clinical relevance. MATERIALS AND METHODS:Clinicopathologic information for 72 primary colo...

journal_title：Anticancer research

authors： Nasir A,Lopez A,Boulware D,Malafa M,Coppola D

更新日期：2011-06-01 00:00:00

abstract：:Thirty-four patients of an Italian population affected by neuroblastoma (NB) were evaluated at diagnosis for multidrug resistance gene (MDR1) and N-myc oncogene amplification. No patients showed MDR1 amplification, while extra copies of the N-myc gene were found in 9 out of 34 patients (26%). N-myc amplification was c...

journal_title：Anticancer research

authors： Corrias MV,Cornaglia-Ferraris P,Di Martino D,Stenger AM,Lanino E,Boni L,Tonini GP

更新日期：1990-07-01 00:00:00

abstract：AIM:This study analyzed the effect of metastasectomy on overall mortality (OM) and perioperative outcomes in patients with metastatic renal cell carcinoma (mRCC) treated exclusively with targeted therapy. MATERIALS AND METHODS:Using the Surveillance, Epidemiology, and End Results (SEER) database (2006-2015), Kaplan-Me...

journal_title：Anticancer research

authors： Palumbo C,Pecoraro A,Knipper S,Rosiello G,Tian Z,Shariat SF,Simeone C,Briganti A,Saad F,Berruti A,Antonelli A,Karakiewicz PI

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND/AIM:Rta, a transactivator of Epstein-Barr virus, is associated with progression of nasopharyngel carcinoma (NPC); however, its mechanism of contribution to the pathogenesis of NPC remains unclear. Interleukin-6 (IL-6), a tumor promoter, is detected in NPC. This in vitro study examined whether and how Rta pro...

journal_title：Anticancer research

authors： Tung KL,Wu YT,Liu C,Lin SC,Wu CH,Wu SY,Chang Y,Lan YY

更新日期：2020-06-01 00:00:00

abstract：:We studied a consecutive series of 54 cases of lower lip squamous cell carcinoma (LLSCC) in order to identify any variables which might predict the development of lymph node metastases. The cases were divided into 38 tumors without metastases (group I) and 16 tumors with lymph node metastases (group II). The following...

journal_title：Anticancer research

authors： Rodolico V,Daniele E,Leonardi V,Marra G,Luciani A,Settineri G,Tralongo V

更新日期：1998-03-01 00:00:00

abstract：:Vesnarinone (3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone), a quinolinone derivative, is an orally active inotropic agent used in Japan for the treatment of chronic heart failure. Recently, it has been reported that vesnarinone induces differentiation and apoptosis in certain types of leuk...

journal_title：Anticancer research

authors： Kawai K,Konishi Y,Izumi K,Sato M,Adachi M,Hozumi M

更新日期：1998-01-01 00:00:00

abstract：:This trial is based on the strategy of reversing O6-methylguanine-DNA methyltransferase (MGMT)-mediated nimustine resistance by depleting MGMT activity with streptozotocin (STZ) pretreatment. Eight patients with recurrent malignant gliomas refractory to previous nimustine chemotherapy were entered in this study. Patie...

journal_title：Anticancer research

authors： Zhao KM,Chen JM,Zuo HZ,Wu Y,Zhang YP

更新日期：1995-03-01 00:00:00

abstract：AIM:To assess outcomes in patients treated with first-line bevacizumab-containing therapy for human epidermal growth factor receptor (HER)2-negative metastatic breast cancer (mBC) at a single centre with a homogenous standard-of-care. PATIENTS AND METHODS:Information on patient and disease characteristics, efficacy, a...

journal_title：Anticancer research

authors： Dieras V,Pop S,Berger F,Dujaric ME,Beuzeboc P,Escalup L,Bidard FC,Cottu PH,LE Tourneau C,Piperno-Neumann S,Laurence V,Robain M,Asselain B,Pierga JY

更新日期：2017-03-01 00:00:00

abstract：AIM:The aim of this study was to analyze the lung cancer detection rate in asymptomatic individuals by the Fluorine-18 fluorodeoxyglucose-positron emission tomography FDG-PET cancer screening program in Japan. MATERIALS AND METHODS:A total of 153,775 asymptomatic individuals underwent the FDG-PET cancer screening prog...

journal_title：Anticancer research

authors： Minamimoto R,Senda M,Jinnouchi S,Terauchi T,Yoshida T,Uno K,Iinuma T,Murano T,Nakashima R,Inoue T

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To investigate the optimal duration of oral HCFU administration for minimization of side effects induced by long-term administration. PATIENTS AND METHODS:In total, 155 patients allocated to two groups of different duration of the therapy were reviewed: twice or three times per day doses of oral HCFU (8 mg/Kg ...

journal_title：Anticancer research

authors： Ito K,Kato T,Koike A,Miura K,Yamaguchi A,Sakou T,Takagi H

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Postoperative pancreatic fistula (POPF) remains a major complication after pancreaticoduodenectomy (PD), and the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) after PD is poor. PATIENTS AND METHODS:A multi-institutional retrospective study was performed in 174 patients who underwent PD ...

journal_title：Anticancer research

authors： Yamashita Y,Yoshizumi T,Fukuzawa K,Nishizaki T,Tsujita E,Kajiyama K,Soejima Y,Yamagata M,Yamamoto K,Adachi E,Sugimachi K,Ikeda Y,Uchiyama H,Maeda T,Itoh S,Harimoto N,Ikegami T,Maehara Y

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:We herein report a comparison of the radiolabels 177Lu and 125I bound to the monoclonal antibody HH1 that targets the CD37 antigen expressed on non-Hodgkin B-cell lymphomas. MATERIALS AND METHODS:Mixtures of 177Lu and 125I-labeled HH1 antibody were co-injected into nude mice carrying Ramos xenografts and th...

journal_title：Anticancer research

authors： Repetto-Llamazares A,Abbas N,Bruland ØS,Dahle J,Larsen RH

更新日期：2014-07-01 00:00:00