Abstract:
BACKGROUND:The secretory epithelial cells of the prostate gland use sophisticated vehicles in the form of prostasomes to relay important information to sperm cells in semen. This prostasome-forming and secretory ability of the epithelial cells is also preserved in poorly differentiated prostate cancer cells. The aim of the present investigation was to conduct a proteomic analysis of metastasis-derived prostasomes. MATERIALS AND METHODS:We investigated prostasomes from vertebral metastases of prostate cancer by 2-dimensional electrophoresis and matrix-assisted laser desorption-ionization time-of-flight (MALDI-TOF) protein characterization. RESULTS:Twenty-five unique protein spots were identified by MALDI-TOF and another five proteins were determined by mass spectrometry (MS)/MS. Annexins A1, A3 and A5, as well as dimethylarginine dimethylaminohydrolase 1 were among the identified proteins. The annexins and dimethylarginine dimethylaminohydrolase 1 found in cancer-derived prostasomes can act, among others, as angiogenic factors and can increase the vascular development in the neighbourhood of the tumour. CONCLUSION:Cancer-derived prostasomes may play an important role in the interaction between tumour cells and their environment.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Ronquist KG,Ronquist G,Larsson A,Carlsson Lsubject
Has Abstractpub_date
2010-02-01 00:00:00pages
285-90issue
2eissn
0250-7005issn
1791-7530pii
30/2/285journal_volume
30pub_type
杂志文章abstract:BACKGROUND/AIM:New anticancer drugs are usually tested on cancer cells in culture in a standard medium. We stimulated immune polynuclear cells by lipopolysaccharides to obtain an enriched medium (EM) containing inflammatory cytokines more closely reflecting the tumor microenvironment and tested a rhenium-diselenium (Re...
journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2006-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2012-02-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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pub_type: 临床试验,杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Anticancer research
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journal_title:Anticancer research
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doi:
更新日期:2015-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2012-12-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2005-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-08-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2016-07-01 00:00:00
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doi:
更新日期:2014-09-01 00:00:00
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journal_title:Anticancer research
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更新日期:1995-09-01 00:00:00
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journal_title:Anticancer research
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更新日期:2015-11-01 00:00:00
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doi:
更新日期:2009-06-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:
更新日期:1998-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
更新日期:1993-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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