Abstract：
BACKGROUND:Recently, metastasis associated with the colon cancer 1 (MACC1) gene was identified by genome-wide search for differentially expressed genes in human colon cancer tissues and metastases. Previously, the MACC1 expression levels were examined in colorectal carcinomas and it was found that MACC1 expression showed significant correlation with peritoneal dissemination and higher stage of TNM classification. MATERIALS AND METHODS:In this study, MACC1 expression levels were analysed in 41 gastric cancer samples using quantitative real-time polymerase chain reaction (QRT-PCR). Results. Distribution of MACC1 expression scores in primary gastric carcinomas was between 0.01 and 4.36 (average ± SD was 1.34 ± 1.31). Subsequently, clinicopathological data were correlated with the MACC1 expression. It was found that MACC1 expression showed significant correlation with peritoneal dissemination (p=0.038). CONCLUSION:These results suggest that MACC1 is more frequently expressed in peritoneal-disseminated gastric carcinomas and may serve as a new parameter for the prognostic prediction of gastric cancer.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Shirahata A,Sakata M,Kitamura Y,Sakuraba K,Yokomizo K,Goto T,Mizukami H,Saito M,Ishibashi K,Kigawa G,Nemoto H,Hibi Ksubject
Has Abstractpub_date
2010-09-01 00:00:00pages
3441-4issue
9eissn
0250-7005issn
1791-7530pii
30/9/3441journal_volume
30pub_type
杂志文章abstract：BACKGROUND/AIM:Prognosis for patients with head and neck squamous cell carcinoma (HNSCC) is poor in most cases and has not improved despite advances in therapy. Novel therapeutic approaches are mandatory in order to improve the situation. Everolimus, an inhibitor of mammalian target of rapamycin, as well as the multi-t...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2016-08-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2001-07-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2016-08-01 00:00:00
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doi：
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更新日期：2013-12-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
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journal_title：Anticancer research
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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pub_type： 临床试验,杂志文章
doi：
更新日期：2000-05-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2013-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2001-07-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2005-11-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2004-03-01 00:00:00
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更新日期：2015-02-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
