Human leukocyte antigen (HLA)-E and HLA-F expression in gastric cancer.

abstract：BACKGROUND/AIM:The aim of this report was to summarize the real-world experience with lipegfilgrastim as a neutropenia prophylaxis in a large cohort of lymphoma patients receiving immuno-, chemo-therapy. PATIENTS AND METHODS:Observational clinical data were derived from two phase IV studies (NADIR and LEOS) with simil...

journal_title：Anticancer research

authors： Pettengell R,Wolff T,Goehler T,Cascavilla N

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND/AIM:The hormonally-active form of vitamin D, 1,25(OH)2D3, demonstrated activity against oral squamous cell carcinoma (OSCC). Cytochrome P450scc (CYP11A1)-derived vitamin D hydroxyderivatives, such as 20(OH)D3 and 1,20(OH)2D3, have overlapping beneficial effects with 1,25(OH)2D3 without causing hypercalcemia....

journal_title：Anticancer research

authors： Oak ASW,Bocheva G,Kim TK,Brożyna AA,Janjetovic Z,Athar M,Tuckey RC,Slominski AT

更新日期：2020-05-01 00:00:00

abstract：:In the presence study we demonstrated that hycanthone and chlorophenoxamine can modulate the resistance of multidrug resistant (MDR) murine L1210 leukemia tumor lines in vitro and in vivo. The circumvention of MDR by hycanthone and chlorophenoxamine in vitro was demonstrated by a short-term test using tritiated nuclei...

journal_title：Anticancer research

authors： Efferth T,Klett T,Mattern J,Osswald H,Pommerenke EW,Stöhr M,Volm M

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND/AIM:The objective of this phase I study was to determine the maximum-tolerated dose (MTD) and recommended dose (RD) of combination therapy with weekly nanoparticle albumin-bound paclitaxel (nab-paclitaxel) and cyclophosphamide (CPA) in metastatic breast cancer (MBC) patients. PATIENTS AND METHODS:Five patie...

journal_title：Anticancer research

authors： Ota D,Akatsuka S,Nishi T,Kato T,Takeuchi M,Tsuji M,Fukuuchi A

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND/AIM:Hepatitis B virus-encoded X protein (HBx) plays a pivotal role in hepatocellular carcinoma (HCC) progression and treatment resistance. Interestingly, our previous study unexpectedly showed that full-length HBx sensitized HCC cells to lapatinib by up-regulating erb-b2 receptor tyrosine kinase 3 (ERBB3). W...

journal_title：Anticancer research

authors： Chen JY,Huang WC,Wei CT,Chien PH,Chen YJ

更新日期：2019-02-01 00:00:00

abstract：AIM:We analyzed pentafecta outcomes [complication-free, continence, potency, negative surgical margins (NSM)], biochemical recurrence (BCR)-free] of 230 patients undergoing robotic-assisted radical prostatectomy (RARP) with bilateral neurovascular (NVB) preservation. PATIENTS AND METHODS:Patient outcomes (group I, cas...

journal_title：Anticancer research

authors： Ou YC,Yang CK,Kang HM,Chang KS,Wang J,Hung SW,Tung MC,Tewari AK,Patel VR

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND/AIM:The transcription factor Y-box-binding protein 1 (YB1) is overexpressed in many types of human cancers. YB1 regulates the G1 phase of the cell cycle by controlling transcription of G1 regulators. Here, we report that YB1 is also involved in regulating G2/M phase. MATERIALS AND METHODS:YB1-depleted TKO c...

journal_title：Anticancer research

authors： Kotake Y,Arikawa N,Tahara K,Maru H,Naemura M

更新日期：2017-04-01 00:00:00

abstract：:Mutations in the p53 gene stimulate cell division. In our study we assessed the prognostic value of mutant p53 overexpression in cervical cancer stage FIGO III detected by immunohistochemistry. In 43 tissue specimens were detected p53 overexpression in 20 cases. Mean survival time was 36.4 (SE +/- 7.66) months in the ...

journal_title：Anticancer research

authors： Gitsch G,Kainz C,Joura E,Breitenecker G

更新日期：1992-11-01 00:00:00

abstract：:A 70-year-old man with a growing liver tumor had undergone subtotal gastrectomy with pancreaticoduodenectomy for gastric cancer (T4b P0 H0 N1, Stage IIIB) 30 months before admission to our hospital. Enhanced computed tomography revealed two hypervascular nodules in segments 4 and 8. After histological diagnosis of sma...

journal_title：Anticancer research

authors： Kinoshita K,Beppu T,Miyata T,Kuramoto K,Yoshida Y,Umesaki N,Kitano Y,Nakagawa S,Okabe H,Nitta H,Imai K,Hayashi H,Yamashita YI,Komori H,Horino K,Misumi A,Baba H

更新日期：2018-03-01 00:00:00

abstract：:Vascular endothelial growth factor A (VEGF) is one of the major regulators of angiogenesis. It plays an important role during the process of physiological and pathological neovascularization. Variant VEGF isoforms are generated as a result of alternative pre-mRNA splicing. To determine the expression of VEGF isoforms ...

journal_title：Anticancer research

authors： Cai C,Böttcher MC,Werner JA,Mandic R

更新日期：2010-03-01 00:00:00

abstract：UNLABELLED:The aim this study was to assess the efficacy of cisplatin-epirubicin-vinorelbine, as primary chemotherapy, in reducing the tumour burden in T2-3 N0-2 breast carcinomas. Breast conservative surgery (BCS) rate, clinical and pathological complete response (pCR), toxicity and 5-year disease-free survival (DFS) ...

journal_title：Anticancer research

authors： Barni S,Visini M,Piazza E,Ionta MT,Ardizzoia A,Arnoldi E,Fava S,Pinotti G,Torretta F,Corradini G,Villa S,Nosenzo AM,Massidda B,Cazzaniga ME

更新日期：2007-07-01 00:00:00

abstract：CASE REPORT:This case study reports on a patient who relapsed with thymoma (mixed type) nine years after tumor resection. After four courses of rescue chemotherapy (docetaxel and cisplatinum), the patient was further diagnosed with pure red cell aplasia. It was noticed that cyclosporin A (CsA), which was administered t...

journal_title：Anticancer research

authors： Li P,Du F,Gong Z,Hu B,Chi C,Chu H,Chen J

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:A cross-sectional study was performed on a cohort of colorectal cancer (CRC) patients to reveal any influence of age, gender, and subsite on grades of malignancy. PATIENTS AND METHODS:Data from histopathological grading according to WHO criteria were pooled into groups of low-grade (well and moderately diff...

journal_title：Anticancer research

authors： Brozek W,Kriwanek S,Bonner E,Peterlik M,Cross HS

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:The clinical significance of the circulating levels of activin A and matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) was investigated in patients with breast cancer (BC) or prostate cancer (PC) with (M1) or without (M0) bone metastasis. PATIENTS AND METHODS:MMP-2, MMP-9 and activin A blood concentrations ...

journal_title：Anticancer research

authors： Incorvaia L,Badalamenti G,Rini G,Arcara C,Fricano S,Sferrazza C,Di Trapani D,Gebbia N,Leto G

更新日期：2007-05-01 00:00:00

abstract：AIM:To investigate the relationship between erythrocyte sedimentation rate (ESR) and postoperative survival of patients with colorectal cancer (CRC). MATERIALS AND METHODS:Relationships between clinical characteristics and overall survival (OS) of patients with CRC were investigated using multivariate analysis. Receiv...

journal_title：Anticancer research

authors： Shibuya N,Ishizuka M,Takagi K,Iwasaki Y,Hachiya H,Aoki T,Kubota K

更新日期：2018-12-01 00:00:00

abstract：UNLABELLED:The aim of this study was to evaluate the efficacy and safety of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in Japanese patients with relapsed or recurrent advanced non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:This was a multicentre, open-label phase II study of er...

journal_title：Anticancer research

authors： Takahashi T,Yamamoto N,Nukiwa T,Mori K,Tsuboi M,Horai T,Masuda N,Eguchi K,Mitsudomi T,Yokota S,Segawa Y,Ichinose Y,Fukuoka M,Saijo N

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Mistletoe lectins (ML), the major biologically active components of mistletoe extracts, which are used for adjuvant cancer therapy, induce apoptosis in lymphocytes and tumor cells. In addition, ML at toxic concentrations induce the release of cytokines, but it remains unclear as to whether dying or activated...

journal_title：Anticancer research

authors： Stein GM,Pfüller U,Schietzel M,Büssing A

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND/AIM:Salvage androgen-deprivation therapy (ADT) is standard treatment for recurrent prostate cancer after curative therapy. However, the prognostic impact of different treatment modalities on the time to castration resistance remains unclear. In this study, we investigated the prognosis of men treated with sa...

journal_title：Anticancer research

authors： Obata H,Shiota M,Akitake N,Takeuchi A,Kashiwagi E,Dejima T,Kiyoshima K,Inokuchi J,Tatsugami K,Eto M

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Cyclooxygenase (COX) is a key enzyme in the conversion of arachidonic acid to prostaglandins and other eicosanoids. A recent report has indicated a selective COX-2 inhibitor resulted in increased apoptosis and down-regulated bcl-2 expression in the androgen-sensitive human prostate cancer cell. We investigat...

journal_title：Anticancer research

authors： Tanji N,Kikugawa T,Yokoyama M

更新日期：2000-07-01 00:00:00

abstract：AIM:To compare clinical outcome in patients with Child-Pugh C hepatocellular carcinoma (HCC) treated with non-transplant therapies and those treated with best supportive care. PATIENTS AND METHODS:A total of 182 patients with HCC with Child-Pugh C cirrhosis were analyzed. Patients were classified into two groups: pati...

journal_title：Anticancer research

authors： Nishikawa H,Kita R,Kimura T,Ohara Y,Takeda H,Sakamoto A,Saito S,Nishijima N,Nasu A,Komekado H,Osaki Y

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Clofarabine is a second-generation nucleoside analogue. The aim of the study was the analysis of ex vivo activity of clofarabine and 14 other anticancer drugs in pediatric and adult acute lymphoblastic (ALL) and myeloid (AML) leukemia. PATIENTS AND METHODS:The ex vivo drug resistance profile was analyzed in...

journal_title：Anticancer research

authors： Styczynski J,Gil L,Derwich K,Wachowiak J,Balwierz W,Badowska W,Krawczuk-Rybak M,Matysiak M,Wieczorek M,Balcerska A,Sonta-Jakimczyk D,Stefaniak J,Kowalczyk J,Urasinski T,Sobol G,Komarnicki M,Wysocki M

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a disinfection by-product in chlorinated drinking water, induces follicular tumors in thyroid glands in Wistar rats. The mechanisms of the MX-induced thyroid gland tumorigenesis are not known. MATERIALS AND METHODS:The expressions of p53 (primary an...

journal_title：Anticancer research

authors： Hakulinen P,Kosma VM,Komulainen H

更新日期：2002-03-01 00:00:00

abstract：:Estrogen analogues, moxestrol (10(-8)-10(-5) M) and ethinyl estradiol (10(-8)-10(-6) M), produced a 30% and 15% inhibition of LoVo cell growth, respectively, in serum-free Ham's F-10 medium. Under the same conditions, no growth effects were observed on these cells following the addition of progesterone or testosterone...

journal_title：Anticancer research

authors： Lointier P,Wildrick DM,Boman BM

更新日期：1992-07-01 00:00:00

abstract：:As a new treatment protocol for neuroblastoma, the chimeric (human/mouse) antiganglioside GD2 antibody chl4.18 is being clinically tested. To improve the therapeutic effect of the antibody alone, we are currently investigating the cytotoxicity of glucose-oxidase coupled to the antibody chl4.18 on spheroids of the neur...

journal_title：Anticancer research

authors： Heiss P,Bernatz S,Bruchelt G,Senekowitsch-Schmidtke R

更新日期：1997-07-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of oxaliplatin (L-OHP) fractionated over two days with bimonthly 5-fluorouracil (5-FU) and leucovorin (LV), as first-line treatment of metastatic colorectal cancer (MCC) patients. PATIENTS AND METHODS:Fifty-four patients with inoperable MCC (median age, 60 years) were entere...

journal_title：Anticancer research

authors： Recchia F,Rea S,Nuzzo A,Lalli A,Di Lullo L,De Filippis S,Saggio G,Biondi E,Massa E,Mantovani G

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:We conducted a phase II study of topotecan (Tp) with cisplatin (CDDP) in previously untreated Japanese patients with extensive-disease small cell lung cancer (ED-SCLC). PATIENTS AND METHODS:In stage 1, a total of 30 patients were allocated to Tp 0.65 mg/m(2) with CDDP 60 mg/m(2) day 1 or Tp 1.00 mg/m(2) wit...

journal_title：Anticancer research

authors： Hosomi Y,Shibuya M,Niho S,Ichinose Y,Kiura K,Sakai H,Takeda K,Kudo S,Eguchi K,Matsui K,Masuda N,Ando M,Watanabe K

更新日期：2011-10-01 00:00:00

abstract：:The local growth and metastatic potential of colorectal cancer is the outcome of a dynamic balance between cancer cells and the immune system, at both a local and systemic level, summarized as the "seed and soil" hypothesis. Until recently, the staging and treatment approaches for colorectal cancer appeared to be orie...

journal_title：Anticancer research

authors： Seretis F,Seretis C,Youssef H,Chapman M

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND/AIM:Adenoid cystic carcinoma (SGC) is a common type of salivary gland cancer (SGC). Surgery is the first treatment choice because chemoradiotherapy is usually not effective. Therefore, new treatment modalities are urgently needed. In this study, it was investigated whether the estrogen axis could be a treatm...

journal_title：Anticancer research

authors： Sumida T,Ishikawa A,Kamata YU,Nakano H,Yamada T,Mori Y

更新日期：2016-06-01 00:00:00

abstract：:To elucidate the rates of appearance of hepatocellular carcinoma (HCC) and the prognosis of alcoholic liver cirrhosis upon infection with hepatitis virus, we retrospectively studied 190 consecutive patients. The patients were divided into three groups based on whether they were exposed either to hepatitis B virus (HBV...

journal_title：Anticancer research

authors： Yamanaka T,Shiraki K,Nakazaawa S,Okano H,Ito T,Deguchi M,Takase K,Nakano T

更新日期：2001-07-01 00:00:00

abstract：:The relationship between apoptosis and chemosensitivity remains complex. We tested the chemosensitivity of 45 patients with advanced breast cancer (BC) ex vivo against anthracyclines (A: doxorubicin, epirubicin), taxanes (T: paclitaxel, docetaxel), cisplatin (DDP) and CMF and any correlation with the expression of p53...

journal_title：Anticancer research

authors： Rein DT,Schöndorf T,Breidenbach M,Janát MM,Weikelt A,Göhring UJ,Becker M,Mallmann P,Kurbacher CM

更新日期：2000-11-01 00:00:00