Reversing multidrug resistance in L1210 tumor cells by hycanthone or chlorophenoxamine in vitro and in vivo.

abstract：BACKGROUND:Polymorphisms altering DNA repair capacity may lead to synergistic effects with tobacco carcinogen-induced lung cancer risk. Based on this hypothesis, the relationship between APE1 polymorphism, smoking and the risk of lung cancer was explored. MATERIALS AND METHODS:The distribution of the APE1 Asp148Glu po...

journal_title：Anticancer research

authors： Agaçhan B,Küçükhüseyin O,Aksoy P,Turna A,Yaylim I,Görmüs U,Ergen A,Zeybek U,Dalan B,Isbir T

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Several studies have reported an association between Hashimoto's disease and thyroid carcinoma although the cause/effect relationship is still controversial. CASE REPORT:In this paper we report the case of a 38-year-old female who first presented with a clinical history of Hashimoto's thyroiditis. Ultrasoun...

journal_title：Anticancer research

authors： Pisani T,Bononi M,Pantellini F,Vecchione A,Giovagnoli MR

更新日期：2002-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a deadly malignant disease with extremely poor prognosis. Many therapeutic modalities have been proposed, but considerable uncertainty still remains about their effectiveness. Inositol hexaphosphate (IP6), a naturally occurring polyphosphorylated carbohydrate, has novel anti-cancer fu...

journal_title：Anticancer research

authors： Vucenik I,Zhang ZS,Shamsuddin AM

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:The prognostic significance of angiogenesis, proliferation and apoptosis after interferon (IFN) was investigated in 96 patients with renal cell carcinoma (RCC). MATERIALS AND METHODS:Microvessel density in the tumor(MVD), proliferative index(PI) and apoptotic index(AI) were quantified using immunohistochemi...

journal_title：Anticancer research

authors： Yoshino S,Kato M,Okada K

更新日期：2000-01-01 00:00:00

abstract：:Multidrug resistance (MDR) is a major clinical obstacle in the treatment of several cancers including hematological malignancies and solid tumors. The ATP-binding cassette transporter B1 (ABCB1) gene and its product, P-glycoprotein (P-gp), is one molecule that is involved in drug resistance. Here we report on the effe...

journal_title：Anticancer research

authors： Onda K,Suzuki R,Tanaka S,Oga H,Oka K,Hirano T

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:To determine the tolerability and efficacy of the combination of gefitinib with gemcitabine plus vinorelbine in metastatic breast cancer (MBC) patients, pretreated with anthracyclines and taxanes. PATIENTS AND METHODS:Women with measurable MBC pretreated with anthracycline- and taxane-based chemotherapy receiv...

journal_title：Anticancer research

authors： Gioulbasanis I,Saridaki Z,Kalykaki A,Vamvakas L,Kalbakis K,Ignatiadis M,Amarantidis K,Kakolyris S,Georgoulias V,Mavroudis D

更新日期：2008-09-01 00:00:00

abstract：AIM:To assess outcomes in patients treated with first-line bevacizumab-containing therapy for human epidermal growth factor receptor (HER)2-negative metastatic breast cancer (mBC) at a single centre with a homogenous standard-of-care. PATIENTS AND METHODS:Information on patient and disease characteristics, efficacy, a...

journal_title：Anticancer research

authors： Dieras V,Pop S,Berger F,Dujaric ME,Beuzeboc P,Escalup L,Bidard FC,Cottu PH,LE Tourneau C,Piperno-Neumann S,Laurence V,Robain M,Asselain B,Pierga JY

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor, accounting for 52% of all primary brain tumor cases and 20% of all intracranial tumors. Recently, evidence for a viral cause has been postulated, possibly SV40 or more likely cytomegalovirus (CMV). One report indicate...

journal_title：Anticancer research

authors： Lehrer S,Labombardi V,Green S,Pessin-Minsley MS,Germano IM,Rosenzweig KE

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Isothiocyanates are constituents of cruciferous vegetables which have been associated with reduced cancer risk partially through their ability to induce apoptosis in malignant cells including melanoma. MATERIALS AND METHODS:We have utilized human malignant melanoma (A375), epidermoid carcinoma (A431) and im...

journal_title：Anticancer research

authors： Mantso T,Sfakianos AP,Atkinson A,Anestopoulos I,Mitsiogianni M,Botaitis S,Perente S,Simopoulos C,Vasileiadis S,Franco R,Pappa A,Panayiotidis MI

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:DNA topoisomerase II alpha (topo II alpha) is associated with active cell proliferation of mammalian cells. Topo II alpha overexpression has been reported in a number of human malignancies and is considered to be related to their biological behaviors. MATERIALS AND METHODS:We examined the expression of topo...

journal_title：Anticancer research

authors： Ohashi Y,Sasano H,Yamaki H,Shizawa S,Kikuchi A,Shineha R,Akaishi T,Satomi S,Nagura H

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:The tumors of the gastrointestinal system have been associated with various immune disorders. The goal of this study was to correlate the presence of the anti-dsDNA autoantibodies in the serum of patients with colorectal adenocarcinoma suffering from the prognosis of their disease. PATIENTS AND METHODS:We i...

journal_title：Anticancer research

authors： Syrigos KN,Charalambopoulos A,Pliarchopoulou K,Varsamidakis N,Machairas A,Mandrekas D

更新日期：2000-11-01 00:00:00

abstract：METHODS:Induction chemotherapy, consisting of 3 courses of cisplatin (30 mg/m2/i.v. 1st and 2nd day), epirubicin (30 mg/m2/i.v. 1st and 2nd day), etoposide (75 mg/m2/i.v. 1st and 2nd day) and bleomycin (15 mg/i.v. 1st and 2nd day), prior to radical hysterectomy and lymph nodes resection, was used in the primary treatme...

journal_title：Anticancer research

authors： Panetta A,Angelelli B,Martoni A

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Once diagnosed, esophageal cancer has a very low overall 5-year survival rate. This study investigates the mechanisms behind the invasiveness and severity of esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS:Transwell invasion chamber was used to subdivide one Taiwanese ESCC cell line, CE81T/...

journal_title：Anticancer research

authors： Chen YK,Chang WS,Wu IC,Li LH,Yang SF,Chen JY,Hsu MC,Chen SH,Wu DC,Lee JM,Huang CH,Goan YG,Chou SH,Huang CT,Wu MT

更新日期：2010-03-01 00:00:00

abstract：:Tricot et al have reported that the nucleoside analog tiazofurin can induce hematologic remissions in patients with chronic myelogenous leukemia in blast crisis (CML-BC). These reports prompted us to begin a derivative, phase II trial of tiazofurin in CML-BC to determine if the promising findings reported by these inv...

journal_title：Anticancer research

authors： Wright DG,Boosalis MS,Waraska K,Oshry LJ,Weintraub LR,Vosburgh E

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:In patients with melanoma, early dissemination via lymphatic and hematogenous routes is frequently seen. Thus, besides clinical follow-up examination and imaging, reliable melanoma-specific serological tumor markers are needed. PATIENTS AND METHODS:We retrospectively compared two serum markers for melanoma,...

journal_title：Anticancer research

authors： Uslu U,Schliep S,Schliep K,Erdmann M,Koch HU,Parsch H,Rosenheinrich S,Anzengruber D,Bosserhoff AK,Schuler G,Schuler-Thurner B

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Recent data indicate the implication of an IGF/IGFBP/protease system in the development of ectopic implants of endometrium (endometriosis) in the pelvic cavity. MATERIAL AND METHODS:We characterized mitogens and protease(s) against IGFBP-3 in the peritoneal fluid of women with or without endometriosis using...

journal_title：Anticancer research

authors： Koutsilieris M,Lavergne E,Lemay A

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. MATERIALS AND METHODS:Pyrosequencing and ancestry informative mar...

journal_title：Anticancer research

authors： Apprey V,Wang S,Tang W,Kittles RA,Southerland WM,Ittmann M,Kwabi-Addo B

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Compliance is an essential aspect for the success of any medical intervention. Adverse events (AEs) contribute significantly to non-compliance with endocrine treatment. The Tamoxifen Exemestane Adjuvant Multinational (TEAM) trial compared five years of adjuvant exemestane therapy with the sequence of tamoxif...

journal_title：Anticancer research

authors： Bossart M,Becker M,Hadji P,Kieback DG,Hasenburg A

更新日期：2012-09-01 00:00:00

abstract：:Major drawbacks to present-day cancer chemotherapy are its intrinsic lack of selectivity for tumour cells, resulting in severe damage to normal rapidly dividing cells, and the widespread emergence of drug resistance. Here experimental evidence is presented demonstrating that PB-100, a beta-carboline alkaloid, selectiv...

journal_title：Anticancer research

authors： Beljanski M,Crochet S,Beljanski MS

更新日期：1993-11-01 00:00:00

abstract：:One of the major obstacles in the treatment of hepatocellular carcinoma (HCC) is the intrinsic/acquired resistance to cisplatin-based chemotherapy. Copper-transporting P-type adenosine triphosphate (ATP7B) has been reported to be associated with cisplatin resistance in vitro. However, the expression of ATP7B has not p...

journal_title：Anticancer research

authors： Sugeno H,Takebayashi Y,Higashimoto M,Ogura Y,Shibukawa G,Kanzaki A,Terada K,Sugiyama T,Watanabe K,Katoh R,Nitta Y,Fukushima T,Koyama Y,Inoue N,Sekikawa K,Ogawa K,Sato Y,Takenoshita S

更新日期：2004-03-01 00:00:00

abstract：:Several skeletal aberrations of the skull have been described for the tumor predisposition syndrome neurofibromatosis type 1 (NF1). Recently, periapical cemental/cemento-osseous dysplasia (COD) has been described in females affected with NF1. This reactive lesion of the hard tissues in tooth-bearing areas of the jaw h...

journal_title：Anticancer research

authors： Friedrich RE,Reul A

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Studies on the role of mast cells (MC) in cancer have given contrasting results. In order to contribute to the clarification of their role, research on breast cancer was carried out, because some aspects of its carcinogenesis, such as the diversity of the hormonal component, differ greatly. MATERIALS AND ME...

journal_title：Anticancer research

authors： della Rovere F,Granata A,Familiari D,D'Arrigo G,Mondello B,Basile G

更新日期：2007-07-01 00:00:00

abstract：:Several signaling pathways have been recognized in normal c-kit-mediated signal transduction following stem cell factor (SCF) stimulation including Janus kinase (JAK)/signal transducer and activator of transcription (STAT), mitogen-activated protein kinase (MAPK) and phosphoinositol 3-kinase (PI-3 K) pathways. In gast...

journal_title：Anticancer research

authors： Paner GP,Silberman S,Hartman G,Micetich KC,Aranha GV,Alkan S

更新日期：2003-05-01 00:00:00

abstract：:The effects of the antineoplastic compound, vinorelbine, on the permeability of the blood-brain barrier (BBB) to the complex Evans blue/albumin were studied. Vinorelbine, at a dose range from 5 to 10 mg/kg, was infused (4 ml/kg over 2 min) into the left carotid artery of anesthetised male Sprague-Dawley rats. BBB disr...

journal_title：Anticancer research

authors： Mouchard-Delmas C,Gourdier B,Vistelle R,Wiczewski M

更新日期：1995-11-01 00:00:00

abstract：:We have studied the effects of PAI-1 on the formation of metastasis using human fibrosarcoma cells and DNA transfection. A clone (1-3C), which shows low constitutive expression of PAI-1 and low metastatic potential to the lung, was selected from human fibrosarcoma cell line HT-1080. Newly-derived clones transfected wi...

journal_title：Anticancer research

authors： Tsuchiya H,Sunayama C,Okada G,Matsuda E,Tomita K,Binder BR

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Basic conventional prognostic factors for breast cancer include the age of the patient, tumor grade, regional lymph nodes status, and estrogen (ER) and progesterone (PR) receptor status. Positivity of the HER2 receptor (c-erbB-2) seems to be a new prognostic and predictive factor. Prognostic factors seem to ...

journal_title：Anticancer research

authors： Finek J,Holubec L Jr,Topolcan O,Elgrova L,Skalova A,Pecen L

更新日期：2007-07-01 00:00:00

abstract：SPECIFIC OBJECTIVE:The Epidermal Growth Factor Receptor (EGFR) is a specific cell membrane receptor that shows homology to the product of the oncogene c-erbB2 in human breast cancer. Growth factors bound to the EGFR are able to stimulate the growth of tumor cells in an autocrine or paracrine manner. Our objective was t...

journal_title：Anticancer research

authors： Oehler MK,Rehn M,Kristen P,Sütterlin M,Caffier H

更新日期：1997-07-01 00:00:00

abstract：:The development of T-lymphocytes (T cells) constitute one of the basic and most vital processes in immunology. Conventional mathematical models, being based on the systems theory, fail to sufficiently distinguish the constituents of thymocytes and are thus of limited significance. On the basis of some well thought-out...

journal_title：Anticancer research

authors： Wang G,Krueger GR,Buja LM

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/AIM:Medullary thyroid cancer (MTC) is highly malignant, metastatic and recurrent, remaining generally incurable, and responsible for approximately 14% of all thyroid carcinoma-related deaths. MTC can metastasize to lymph nodes, trachea and distant organs, such as brain, lungs, liver and bones. MTC cells are ...

journal_title：Anticancer research

authors： Damaskos C,Garmpis N,Valsami S,Spartalis E,Antoniou EA,Tomos P,Karamaroudis S,Zoumpou T,Pergialiotis V,Stergios K,Michaelides C,Kontzoglou K,Perrea D,Nikiteas N,Dimitroulis D

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Preclinical studies suggest that 1,25-dihydroxyvitamin D [1,25(OH)2D] and celecoxib inhibit prostaglandins (PGs) associated with cancer through different mechanisms. We determined if there was synergy in their use. PATIENTS AND METHODS:A total of 36 healthy women received daily for one month/menstrual cycle...

journal_title：Anticancer research

authors： Qin W,Smith C,Jensen M,Holick MF,Sauter ER

更新日期：2013-09-01 00:00:00