The importance of prognostic factors in premenopausal women with breast cancer.

abstract：BACKGROUND/AIM:Methionine inhibits proliferation of breast and prostate cancer cells. This study aimed to determine cell cycle effects of methionine and selectivity for cancer cells. MATERIALS AND METHODS:MCF-7 (breast), LNCaP (prostate), and LS-174 (colon) cancer cells (wild-type p53), DU-145 (prostate) and SW480 (co...

journal_title：Anticancer research

authors： Benavides MA,Hagen KL,Fang W,Du P,Lin S,Moyer MP,Yang W,Bland KI,Grizzle WE,Bosland MC

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is one of the most important factors for angiogenesis in various tumors. However, its clinical significance in extrahepatic biliary tract carcinoma remains unclear. MATERIALS AND METHODS:To clarify the association of VEGF expression with the clinicopathological feat...

journal_title：Anticancer research

authors： Hida Y,Morita T,Fujita M,Miyasaka Y,Horita S,Fujioka Y,Nagashima K,Katoh H

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND/AIM:Anaplastic thyroid cancer (ATC) is one of the most aggressive human malignancies, remaining generally incurable. Histone deacetylase (HDAC) seems to play a role in regulating transcription of genes involved in ATC, making HDAC inhibitors (HDACI) promising anticancer drugs for ATC. The purpose of this rev...

journal_title：Anticancer research

authors： Spartalis E,Athanasiadis DI,Chrysikos D,Spartalis M,Boutzios G,Schizas D,Garmpis N,Damaskos C,Paschou SA,Ioannidis A,Tsourouflis G,Dimitroulis D,Nikiteas NI

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Concurrent chemoradiotherapy with gemcitabine improves median survival for patients with unresectable pancreatic cancer. Recently, hyperfractionated accelerated radiotherapy (HART) has been used to treat these patients; however, the safety and efficacy are not well defined. PATIENTS AND METHODS:The standard...

journal_title：Anticancer research

authors： Maemura K,Shinchi H,Noma H,Mataki Y,Kurahara H,Maeda S,Hiraki Y,Nakajo M,Natsugoe S,Takao S

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Epithelioid haemangioendothelioma (EHE) is a rare vascular tumour, which can arise at any site. There is little published data about the management of these tumours. PATIENTS AND METHODS:A retrospective review of patients with histologically-proven EHE presenting to the Royal Marsden Hospital from January 1...

journal_title：Anticancer research

authors： Yousaf N,Maruzzo M,Judson I,Al-Muderis O,Fisher C,Benson C

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Copper transporters (CTR) also regulate the cellular transport of platinum drugs, but their role in platinum resistance of ovarian cancer has not been elucidated. MATERIALS AND METHODS:CTR expression in ovarian cancer tissues resected from patients treated by platinum-based chemotherapy was evaluated immuno...

journal_title：Anticancer research

authors： Yoshida H,Teramae M,Yamauchi M,Fukuda T,Yasui T,Sumi T,Honda K,Ishiko O

更新日期：2013-04-01 00:00:00

abstract：:Ovarian tumors of low malignant potential (LMPs) are intermediate between adenomas and ovarian carcinomas (OCs); however, whether an LMP is a precursor of OC or is a unique type of tumor that will not progress to OC is still controversial. To gain better insight into the relationship between LMP and OC, we compared pr...

journal_title：Anticancer research

authors： Nakayama K,Takebayashi Y,Hata K,Fujiwaki R,Iida K,Fukumoto M,Miyazaki K

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Resveratrol (RES) inhibits cell growth, induces apoptosis and augments chemotherapeutics in multiple cancer types, although its effects on drug-resistant cancer cells are unknown. MATERIALS AND METHODS:To study the effects of resveratrol in triple-negative breast cancer cells that are resistant to the commo...

journal_title：Anticancer research

authors： Sprouse AA,Herbert BS

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Loss of heterozygosity (LOH) may be a valuable tool for detection of malignant proceedings. The aim of our study was to investigate LOH in the serum of patients with adenocarcinoma of the distal oesophagus and the cardia for diagnostic and prognostic utility. PATIENTS AND METHODS:Matched tumour and serum sa...

journal_title：Anticancer research

authors： Wachowiak R,Kaifi JT,Schurr PG,Merkert P,Yekebas E,Schwarzenbach H,Strate T,Sauter G,Izbicki JR

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIM:N6-Methyladenosine (m6A), the most abundant internal modification of RNA, plays a critical role in cancer development. However, the clinical implications of m6A in hepatocellular carcinoma (HCC) remain unclear. MATERIALS AND METHODS:We analyzed 177 HCC and paired noncancerous liver tissues from patients...

journal_title：Anticancer research

authors： Nakagawa N,Tanaka K,Sonohara F,Kandimalla R,Sunagawa Y,Inokawa Y,Takami H,Hayashi M,Yamada S,Kanda M,Tanaka C,Nakayama G,Koike M,Kodera Y

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND/AIM:Few data are available on the utility of definitive radiation therapy (RT) for pediatric craniopharyngioma. This study sought to evaluate practice patterns and patient outcomes using the Surveillance Epidemiology and End Results database from 2004-2014. MATERIALS AND METHODS:Overall survival (OS) was co...

journal_title：Anticancer research

authors： Hill TK,Baine MJ,Verma V,Alam M,Lyden ER,Lin C,Connolly EP,Zhang C

更新日期：2019-02-01 00:00:00

abstract：:Development and progression of tumours is generally driven by an accumulation of genetic alterations. In this study we correlated chromosome 17 aneuploidy to invasiveness of bladder cancer by the method of fluorescence in situ hybridisation (FISH) in urinary cytospins. We investigated the value of FISH compared to DNA...

journal_title：Anticancer research

authors： Krause FS,Feil G,Zumbrägel A,Bichler KH

更新日期：2000-11-01 00:00:00

abstract：:Cell proliferation measurements using bromodeoxyuridine administration to patients and flow cytometry to measure Tpot in head and neck cancer are discussed. Several hundred patients have now been assessed and the majority of studies suggest that this group of tumours represent a relatively fast proliferating site with...

journal_title：Anticancer research

authors： Wilson GD

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:This study aimed to elucidate the prognostic value of vimentin expression in patients with intrahepatic cholangiocarcinoma (ICC). PATIENTS AND METHODS:A retrospective analysis of 21 patients who underwent resection for ICC was conducted. Vimentin expression was positive when single tumour cells or cell clus...

journal_title：Anticancer research

authors： Korita PV,Wakai T,Ajioka Y,Inoue M,Takamura M,Shirai Y,Hatakeyama K

更新日期：2010-06-01 00:00:00

abstract：:The response of the blood-forming and supportive stromal compartments of the marrow to a localized, fractionated course of radiotherapy [FxRT; 2.0 Gy (q24 h x 5)-->74 Gy] was examined in the C57Bl/6 mouse using the hematopoietic progenitor and the cobblestone-forming cell (CAFC) assays as end-points for the blood-form...

journal_title：Anticancer research

authors： Kovacs CJ,Evans MJ,Daly BM

更新日期：2003-05-01 00:00:00

abstract：:Megakaryocyte polyploidization responds to platelet demand and results from the lack of cytoplasmic separation while the nucleus keeps dividing. In normal telophase, the plane of the actin constriction ring is determined by the tubulin spindle. In order to investigate the role of tubulin in the megakaryocyte polyploid...

journal_title：Anticancer research

authors： Baatout S,Chatelain B,Staquet P,Symann M,Chatelain C

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Tissue polypeptide antigen (TPA) is a circulating complex of polypeptide fragments from cytokeratins 8, 18 and 19. It is a tumour-related protein. TPA is an indicator of higher cell proliferation. One function of TP53 is the suppression of apoptosis. TP53 mutations are frequently correlated with tumour devel...

journal_title：Anticancer research

authors： Ecke TH,Lenk SV,Schlechte HH,Loening SA

更新日期：2003-03-01 00:00:00

abstract：:The accumulation of vincristine in leukemic cells and normal mononuclear cells and the effect of verapamil on cellular drug accumulation were studied. Leukemic cells were isolated from 10 patients with chronic lymphocytic leukemia, immunocytoma and prolymphocytic leukemia. Normal mononuclear cells were collected from ...

journal_title：Anticancer research

authors： Gruber A,Reizenstein P,Peterson C

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated patients undergoing salvage hysterectomy after brachytherapy (BT) following concomitant chemoradiation (CRT) for locally advanced cervical cancers (LACC), when residual disease was suspected. PATIENTS AND METHODS:From 2004 to 2013, 29 patients had a radical hysterectomy at the Gustave Rouss...

journal_title：Anticancer research

authors： Gosset M,Chargari C,Bentivegna E,Leary A,Genestie C,Maulard A,Morice P,Gouy S

更新日期：2019-06-01 00:00:00

abstract：:Recently, it has been reported that total clearance (CLtot) of vancomycin is significantly higher in patients with malignancies compared to those without malignancies. In the present study, to clarify the mechanism of this enhancement in malignancy, we adopted rat animal models, using chemical carcinogen-induced osteo...

journal_title：Anticancer research

authors： Shimada I,Iwata C,Taga S,Teramachi H,Nomura M,Miyamoto K,Tsuciya H,Wada T,Kimura K,Matsushita R

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Genetic polymorphisms of carcinogen-metabolizing enzyme genes have been associated with the risk of oral squamous cell carcinoma and oral leukoplakia. The overexpression of p53 protein is the most common genetic alteration in head and neck cancer. In the present study the combined or isolated presence of glu...

journal_title：Anticancer research

authors： Duarte EC,Ribeiro DC,Gomez MV,Ramos-Jorge ML,Gomez RS

更新日期：2008-03-01 00:00:00

abstract：:Pro- and anti-apoptotic factors and intracellular signaling pathways are targets for therapeutic development of anticancer agents. Carboxyamido-triazole (CAI) is an inhibitor of transmembrane calcium influx and intracellular calcium-requiring signal transduction pathways. The present study investigates the effects of ...

journal_title：Anticancer research

authors： Perabo FG,Wirger A,Kamp S,Lindner H,Schmidt DH,Müller SC,Kohn EC

更新日期：2004-09-01 00:00:00

abstract：:Although several chemical carcinogenes have been shown to induce malignant transformation in human cells in culture, the molecular events involved in conversion of normal cells to malignant cells remain unknown at present. Normal human cells seem to be resistant to transformation by a single oncogene unless these cell...

journal_title：Anticancer research

authors： Khoobyarian N,Marczynska B

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND/AIM:Ouabain, a plant-derived product/substance with Na+/K+-ATPase inhibiting properties, has been shown to exert anti-cancer activity on human cancer cells. This is the first study to investigate the effect of ouabain on apoptotic cell death of human osteosarcoma-derived U-2 OS cells. MATERIALS AND METHODS:...

journal_title：Anticancer research

authors： Chou WH,Liu KL,Shih YL,Chuang YY,Chou J,Lu HF,Jair HW,Lee MZ,Au MK,Chung JG

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Cyclooxygenase (COX) is a key enzyme in the conversion of arachidonic acid to prostaglandins and other eicosanoids. A recent report has indicated a selective COX-2 inhibitor resulted in increased apoptosis and down-regulated bcl-2 expression in the androgen-sensitive human prostate cancer cell. We investigat...

journal_title：Anticancer research

authors： Tanji N,Kikugawa T,Yokoyama M

更新日期：2000-07-01 00:00:00

abstract：UNLABELLED:The aim of the present study was to evaluate the effectiveness and safety of hepatic re-resection for breast cancer liver metastases. PATIENTS AND METHODS:Between January 2004 and December 2014 seven patients were submitted to liver re-resection for breast cancer liver metastases at our Center. The main inc...

journal_title：Anticancer research

authors： BacalbaȘa N,Balescu I,Dima S,Popescu I

更新日期：2015-12-01 00:00:00

abstract：:Experiments were designed to compare the efficacy of recombinant IL-2 immunotherapy and IL-2 gene therapy of i.p. growing murine plasmacytoma X63-Ag8.653. The kinetics of peritoneal exudate mononuclear cells were monitored during the progression and gene therapy of the plasmacytoma, using cytofluorometric analysis and...

journal_title：Anticancer research

authors： Bubeník J,Zeuthen J,Bubeníková D,Símová J,Jandlová T

更新日期：1993-09-01 00:00:00

abstract：:The authors report their experience in the radioimmunodetection of recurrent colorectal cancer in comparison with traditional examinations. 485 patients were studied after radical surgery for colorectal cancer: 168 (Group 1) were studied with a radioimmunoassisted follow-up plan including: Immunoscintigraphy (IS), ser...

journal_title：Anticancer research

authors： Prati U,Roveda L,Cantoni A,Saponaro R,Bosi F,Sandolo R,Zonta A

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND/AIM:Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel clinical approach to the treatment of peritoneal carcinomatosis. A well-established, not anatomic ex vivo PIPAC model was used to investigate the influence of changes in internal pressure, distance of the Micropump(©) (MIP) to the distri...

journal_title：Anticancer research

authors： Khosrawipour V,Khosrawipour T,Falkenstein TA,Diaz-Carballo D,Förster E,Osma A,Adamietz IA,Zieren J,Fakhrian K

更新日期：2016-09-01 00:00:00

abstract：:The anti-tumor properties of arsenic trioxide have attracted extensive attention after successfully inducing apoptosis of acute promyelocytic leukemia cells. However, the therapeutic spectrum should not only be restricted to acute promyelocytic leukemia, but should also extend into other types of tumor cells. In this ...

journal_title：Anticancer research

authors： Tsai CW,Chang NW,Tsai RY,Wang RF,Hsu CM,Lin SS,Wu CN,Sun SS,Tsai MH,Bau DT

更新日期：2010-09-01 00:00:00