Abstract：
BACKGROUND/AIM:N6-Methyladenosine (m6A), the most abundant internal modification of RNA, plays a critical role in cancer development. However, the clinical implications of m6A in hepatocellular carcinoma (HCC) remain unclear. MATERIALS AND METHODS:We analyzed 177 HCC and paired noncancerous liver tissues from patients who underwent hepatectomy according to global m6A quantification and expression of m6A demethylases fat mass and obesity-associated protein (FTO) and alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5). RESULTS:The global m6A quantification revealed no significant difference between HCC and non-cancerous tissue. The expression of m6A demethylases FTO and ALKBH5, was significantly lower in HCC than in non-cancerous tissues (both p<0.001). Furthermore, low ALKBH5 expression in non-cancerous tissues was significantly correlated with worse recurrence-free survival (median of 16.3 vs. 38.9 months, p=0.001). CONCLUSION:m6A in HCC and its demethylase in surrounding non-cancerous liver tissues might be involved in inherent mechanisms for HCC development and affect malignant potential after HCC resection.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Nakagawa N,Tanaka K,Sonohara F,Kandimalla R,Sunagawa Y,Inokawa Y,Takami H,Hayashi M,Yamada S,Kanda M,Tanaka C,Nakayama G,Koike M,Kodera Ydoi
10.21873/anticanres.14690subject
Has Abstractpub_date
2020-12-01 00:00:00pages
6665-6676issue
12eissn
0250-7005issn
1791-7530pii
40/12/6665journal_volume
40pub_type
杂志文章abstract：BACKGROUND:PS2-expression is controlled by estrogens and is a prognostic factor for long-term and post-relapse survival. Breast carcinomas associated with a BRCA1 mutation (BRCA1-BC'S) exhibit many specific features, particularly for ER expression. Our purpose was to determine if pS2-expression was different in BRCA1-B...
journal_title：Anticancer research
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journal_title：Anticancer research
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abstract：:Metastatic renal cell carcinoma (RCC) has a poor response to anticancer chemotherapy and radiotherapy. While immunotherapy and molecular targeted drugs have been used as first-line therapy for RCC metastasis, the response rate to these agents is low. We report the case of a patient with lung and bone metastases of RCC...
journal_title：Anticancer research
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更新日期：2011-09-01 00:00:00
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journal_title：Anticancer research
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更新日期：2014-09-01 00:00:00
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journal_title：Anticancer research
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2003-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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journal_title：Anticancer research
pub_type： 杂志文章
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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doi：
更新日期：2010-02-01 00:00:00
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2003-05-01 00:00:00
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更新日期：2014-06-01 00:00:00
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doi：
更新日期：2001-11-01 00:00:00
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pub_type： 临床试验,杂志文章,评审
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更新日期：1989-11-01 00:00:00
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doi：
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journal_title：Anticancer research
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doi：
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